hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02757
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| STK4 | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | UniProt NCBI |
| STK3 | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | UniProt NCBI |
| RASSF2 | Ras association domain-containing protein 2 | UniProt NCBI |
| RASSF1 | Ras association domain-containing protein 1 | UniProt NCBI |
| SAV1 | Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) | UniProt NCBI |
| RASSF6 | Ras association domain-containing protein 6 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04392 | 2.99017586653e-12 | 0.833333333333 | RASSF1 RASSF2 SAV1 RASSF6 STK3 | Hippo signaling pathway - multiple species |
| WP:WP4537 | 1.70690021658e-06 | 0.5 | RASSF1 SAV1 STK3 | Hippo-Yap signaling pathway |
| KEGG:04390 | 5.41943690311e-06 | 0.666666666667 | RASSF1 SAV1 RASSF6 STK3 | Hippo signaling pathway |
| REAC:R-HSA-2028269 | 5.75676182894e-06 | 0.5 | STK4 SAV1 STK3 | Signaling by Hippo |
| CORUM:6403 | 8.39001385941e-06 | 0.333333333333 | STK4 SAV1 | MST1-SAV1 complex |
| CORUM:6404 | 8.39001385941e-06 | 0.333333333333 | STK3 SAV1 | MST2-SAV1 complex |
| CORUM:6621 | 2.51655344529e-05 | 0.333333333333 | STK3 SAV1 | NEK2A-SAV1-STK3 complex |
| CORUM:6716 | 2.51655344529e-05 | 0.333333333333 | STK4 STK3 | DLG5-MST1-MST2 complex |
| WP:WP4542 | 0.00241892882621 | 0.333333333333 | STK3 SAV1 | Overview of leukocyte-intrinsic Hippo pathway functions |
| WP:WP4534 | 0.00455083797199 | 0.333333333333 | STK3 SAV1 | Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms |
| WP:WP3959 | 0.00822079355503 | 0.333333333333 | RASSF1 STK3 | DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM |
| KEGG:05223 | 0.0124835568261 | 0.333333333333 | RASSF1 STK4 | Non-small cell lung cancer |
| WP:WP4255 | 0.0133332445565 | 0.333333333333 | RASSF1 STK4 | Non-small cell lung cancer |
| GO:0035329 | 0.0140408309691 | 0.5 | STK4 SAV1 STK3 | hippo signaling |
| MIRNA:hsa-miR-1256 | 0.0233911114642 | 0.333333333333 | STK4 RASSF6 | hsa-miR-1256 |
| WP:WP4541 | 0.0282758493646 | 0.333333333333 | STK3 SAV1 | Hippo-Merlin Signaling Dysregulation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RASSF1 | STK4 | 1.0 | 0.949 | hein_WMM bioplex (RASSF1) bioplex_WMM hein (RASSF1) |
| STK4 | STK3 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| RASSF1 | STK3 | 0.999 | 0.949 | hein_WMM bioplex (RASSF1) bioplex_WMM hein (RASSF1) |
| STK4 | RASSF2 | 0.988 | 0.901 | bioplex (RASSF2) bioplex_WMM gupta_WMM |
| STK3 | RASSF2 | 0.977 | 0.893 | bioplex (RASSF2) bioplex_WMM gupta_WMM |
| SAV1 | STK3 | 0.324 | 0.512 | bioplex (SAV1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SAV1 | STK4 | 0.155 | 0.416 | bioplex (SAV1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| STK4 | RASSF6 | 0.068 | 0.349 | bioplex (RASSF6) bioplex_WMM |
| STK3 | RASSF6 | 0.036 | 0.267 | bioplex (RASSF6) bioplex_WMM |
Images
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Complex HuMAP2_02757 has an average edge precision of 0.687 which is ranked 1423 out of all 6965 complexes.
Related Complexes