hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02784
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CARMIL1 | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | UniProt NCBI |
| ARHGEF2 | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | UniProt NCBI |
| PAK5 | Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7) | UniProt NCBI |
| PAK4 | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | UniProt NCBI |
| PAK6 | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | UniProt NCBI |
| ARHGEF11 | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428540 | 1.70064822019e-06 | 0.5 | PAK4 PAK5 PAK6 | Activation of RAC1 |
| WP:WP4564 | 8.94077488385e-06 | 0.5 | PAK4 PAK5 PAK6 | Neural Crest Cell Migration during Development |
| WP:WP4565 | 1.16039925365e-05 | 0.5 | PAK4 PAK5 PAK6 | Neural Crest Cell Migration in Cancer |
| WP:WP4534 | 1.59103859767e-05 | 0.5 | PAK4 PAK5 PAK6 | Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms |
| WP:WP4205 | 4.35658034931e-05 | 0.5 | PAK4 PAK5 PAK6 | MET in type 1 papillary renal cell carcinoma |
| KEGG:05211 | 6.61834063766e-05 | 0.5 | PAK4 PAK5 PAK6 | Renal cell carcinoma |
| KEGG:04012 | 0.000131475958172 | 0.5 | PAK4 PAK5 PAK6 | ErbB signaling pathway |
| WP:WP4263 | 0.000136265489266 | 0.5 | PAK4 PAK5 PAK6 | Pancreatic adenocarcinoma pathway |
| WP:WP673 | 0.000146437904639 | 0.5 | PAK4 PAK5 PAK6 | ErbB Signaling Pathway |
| KEGG:04660 | 0.000194995535624 | 0.5 | PAK4 PAK5 PAK6 | T cell receptor signaling pathway |
| WP:WP4541 | 0.000253909359144 | 0.5 | PAK4 PAK5 PAK6 | Hippo-Merlin Signaling Dysregulation |
| WP:WP51 | 0.000551527499474 | 0.5 | PAK4 PAK5 PAK6 | Regulation of Actin Cytoskeleton |
| WP:WP4223 | 0.000892901960021 | 0.5 | PAK4 PAK5 PAK6 | Ras Signaling |
| KEGG:04360 | 0.00120635789569 | 0.5 | PAK4 PAK5 PAK6 | Axon guidance |
| KEGG:04014 | 0.0016712630824 | 0.5 | PAK4 PAK5 PAK6 | Ras signaling pathway |
| KEGG:04810 | 0.00175401113695 | 0.5 | PAK4 PAK5 PAK6 | Regulation of actin cytoskeleton |
| KEGG:04510 | 0.00181065209593 | 0.5 | PAK4 PAK5 PAK6 | Focal adhesion |
| KEGG:05170 | 0.00211201253822 | 0.5 | PAK4 PAK5 PAK6 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-422475 | 0.00323741737614 | 0.666666666667 | PAK4 ARHGEF11 PAK5 PAK6 | Axon guidance |
| GO:0007010 | 0.00542702135196 | 1.0 | PAK4 CARMIL1 ARHGEF2 ARHGEF11 PAK6 PAK5 | cytoskeleton organization |
| REAC:R-HSA-376176 | 0.0091602408755 | 0.5 | PAK4 PAK5 PAK6 | Signaling by ROBO receptors |
| WP:WP185 | 0.0235215924424 | 0.333333333333 | PAK4 PAK6 | Integrin-mediated Cell Adhesion |
| REAC:R-HSA-193648 | 0.0302745579484 | 0.333333333333 | ARHGEF11 ARHGEF2 | NRAGE signals death through JNK |
| REAC:R-HSA-1266738 | 0.0323042935377 | 0.666666666667 | PAK4 ARHGEF11 PAK5 PAK6 | Developmental Biology |
| REAC:R-HSA-204998 | 0.0499130144295 | 0.333333333333 | ARHGEF11 ARHGEF2 | Cell death signalling via NRAGE, NRIF and NADE |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PAK4 | PAK6 | 1.0 | 0.949 | bioplex (PAK4) bioplex_WMM |
| PAK5 | PAK4 | 1.0 | 0.949 | bioplex (PAK4,PAK5) bioplex_WMM |
| ARHGEF11 | PAK4 | 0.941 | 0.854 | bioplex (PAK4) bioplex_WMM youn_WMM gupta_WMM |
| CARMIL1 | PAK4 | 0.423 | 0.573 | bioplex (PAK4) bioplex_WMM youn_WMM gupta_WMM |
| ARHGEF11 | PAK5 | 0.248 | 0.472 | bioplex (PAK5) bioplex_WMM |
| CARMIL1 | PAK5 | 0.086 | 0.352 | bioplex (PAK5) bioplex_WMM |
| PAK5 | ARHGEF2 | 0.034 | 0.263 | bioplex (PAK5) bioplex_WMM |
| CARMIL1 | ARHGEF11 | 0.01 | 0.11 | bioplex_WMM youn_WMM WMM_only |
| PAK5 | PAK6 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| ARHGEF11 | ARHGEF2 | 0.009 | 0.097 | bioplex_WMM youn_WMM WMM_only |
| CARMIL1 | PAK6 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| ARHGEF11 | PAK6 | 0.008 | 0.094 | bioplex_WMM WMM_only |
| PAK4 | ARHGEF2 | 0.008 | 0.091 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CARMIL1 | ARHGEF2 | 0.008 | 0.058 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_02784 has an average edge precision of 0.362 which is ranked 3734 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CARMIL1 | HuMAP2_00703 HuMAP2_02784 |
| ARHGEF2 | HuMAP2_02784 HuMAP2_05147 |
| PAK5 | HuMAP2_00703 HuMAP2_01506 HuMAP2_02784 HuMAP2_03420 |
| PAK4 | HuMAP2_00703 HuMAP2_01506 HuMAP2_02784 HuMAP2_03420 |
| PAK6 | HuMAP2_00703 HuMAP2_01506 HuMAP2_02784 HuMAP2_03420 |
| ARHGEF11 | HuMAP2_00703 HuMAP2_02784 HuMAP2_03163 HuMAP2_03420 |