hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02795
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DYNC1H1 | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | UniProt NCBI |
| DYNC1I2 | Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) | UniProt NCBI |
| DYNC1LI2 | Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) | UniProt NCBI |
| DYNC1LI1 | Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4532 | 2.65926771259e-10 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Intraflagellar transport proteins binding to dynein |
| KEGG:04962 | 1.6514891496e-09 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Vasopressin-regulated water reabsorption |
| KEGG:05132 | 1.38508961964e-08 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Salmonella infection |
| REAC:R-HSA-6811436 | 2.08858653508e-08 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-3371497 | 2.455200129e-08 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| GO:0005868 | 1.1819649475e-07 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | cytoplasmic dynein complex |
| KEGG:04145 | 2.39127731928e-07 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Phagosome |
| REAC:R-HSA-141424 | 2.53401411634e-07 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 2.53401411634e-07 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-6807878 | 3.14225712992e-07 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | COPI-mediated anterograde transport |
| REAC:R-HSA-69618 | 4.68014787616e-07 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-2132295 | 6.49361324137e-07 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | MHC class II antigen presentation |
| REAC:R-HSA-2500257 | 7.44977867715e-07 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-8856688 | 1.03013477297e-06 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-5663220 | 1.12976343415e-06 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | RHO GTPases Activate Formins |
| REAC:R-HSA-199977 | 1.55794915768e-06 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | ER to Golgi Anterograde Transport |
| GO:0030286 | 2.47053849812e-06 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | dynein complex |
| REAC:R-HSA-948021 | 2.97418404602e-06 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-2467813 | 4.10034927091e-06 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Separation of Sister Chromatids |
| REAC:R-HSA-68882 | 4.87252320159e-06 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Mitotic Anaphase |
| REAC:R-HSA-68877 | 4.87252320159e-06 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Mitotic Prometaphase |
| REAC:R-HSA-2555396 | 4.976193908e-06 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-6811442 | 5.51957873707e-06 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-446203 | 2.44087780328e-05 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Asparagine N-linked glycosylation |
| REAC:R-HSA-69620 | 2.51048958535e-05 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Cell Cycle Checkpoints |
| CORUM:6038 | 3.01612206104e-05 | 0.5 | DYNC1H1 DYNC1LI1 | Dynein complex |
| REAC:R-HSA-195258 | 3.37844063501e-05 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | RHO GTPase Effectors |
| CORUM:6039 | 5.02641999304e-05 | 0.5 | DYNC1H1 DYNC1LI1 | Dynein-dynactin complex |
| GO:0019886 | 5.95648368816e-05 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| GO:0002495 | 6.2335294411e-05 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | antigen processing and presentation of peptide antigen via MHC class II |
| GO:0002504 | 6.52012849586e-05 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| REAC:R-HSA-68886 | 7.5124113335e-05 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | M Phase |
| REAC:R-HSA-2262752 | 0.00010216546718 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Cellular responses to stress |
| GO:0045504 | 0.000103844122491 | 0.75 | DYNC1I2 DYNC1LI2 DYNC1LI1 | dynein heavy chain binding |
| REAC:R-HSA-194315 | 0.000127392742142 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Signaling by Rho GTPases |
| REAC:R-HSA-8953897 | 0.00021167720149 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Cellular responses to external stimuli |
| REAC:R-HSA-69278 | 0.000264779714116 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Cell Cycle, Mitotic |
| GO:0005875 | 0.000313257328826 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | microtubule associated complex |
| WP:WP4352 | 0.000349541974194 | 0.75 | DYNC1I2 DYNC1LI1 DYNC1H1 | Ciliary landscape |
| REAC:R-HSA-199991 | 0.000426145417081 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.000528360370521 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Vesicle-mediated transport |
| REAC:R-HSA-1640170 | 0.000545854331888 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Cell Cycle |
| REAC:R-HSA-1280218 | 0.000660113802024 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Adaptive Immune System |
| GO:0002478 | 0.000691429733885 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | antigen processing and presentation of exogenous peptide antigen |
| GO:0019884 | 0.000726323315176 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | antigen processing and presentation of exogenous antigen |
| GO:0048002 | 0.000879263724448 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | antigen processing and presentation of peptide antigen |
| GO:0006888 | 0.00110299395387 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| GO:0019882 | 0.0014249330287 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | antigen processing and presentation |
| GO:0007018 | 0.00286921344524 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | microtubule-based movement |
| REAC:R-HSA-597592 | 0.0094488419023 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Post-translational protein modification |
| GO:0048193 | 0.0119815015829 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Golgi vesicle transport |
| REAC:R-HSA-380284 | 0.0221036214141 | 0.5 | DYNC1I2 DYNC1H1 | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-380259 | 0.0221036214141 | 0.5 | DYNC1I2 DYNC1H1 | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-8854518 | 0.0241365318386 | 0.5 | DYNC1I2 DYNC1H1 | AURKA Activation by TPX2 |
| REAC:R-HSA-380270 | 0.0307679435258 | 0.5 | DYNC1I2 DYNC1H1 | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-380287 | 0.0307679435258 | 0.5 | DYNC1I2 DYNC1H1 | Centrosome maturation |
| REAC:R-HSA-2565942 | 0.0347967852364 | 0.5 | DYNC1I2 DYNC1H1 | Regulation of PLK1 Activity at G2/M Transition |
| REAC:R-HSA-168256 | 0.0358063812597 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Immune System |
| REAC:R-HSA-380320 | 0.0399558314157 | 0.5 | DYNC1I2 DYNC1H1 | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-392499 | 0.0403329683602 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | Metabolism of proteins |
| GO:0005813 | 0.0426155998333 | 1.0 | DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC1H1 | centrosome |
| REAC:R-HSA-5620912 | 0.0445250072801 | 0.5 | DYNC1I2 DYNC1H1 | Anchoring of the basal body to the plasma membrane |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DYNC1LI1 | DYNC1I2 | 1.0 | 0.949 | hein_WMM bioplex (DYNC1I2,DYNC1LI1) bioplex_WMM boldt youn_WMM hein (DYNC1LI1) Malo gupta_WMM fraction boldt_WMM |
| DYNC1LI1 | DYNC1H1 | 1.0 | 0.949 | hein_WMM bioplex (DYNC1LI1) bioplex_WMM boldt hein (DYNC1H1,DYNC1LI1) Malo gupta_WMM fraction boldt_WMM |
| DYNC1LI2 | DYNC1H1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt hein (DYNC1H1) Malo gupta_WMM fraction boldt_WMM |
| DYNC1I2 | DYNC1H1 | 1.0 | 0.949 | hein_WMM bioplex (DYNC1I2) bioplex_WMM boldt hein (DYNC1H1) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| DYNC1I2 | DYNC1LI2 | 1.0 | 0.949 | hein_WMM bioplex (DYNC1I2) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| DYNC1LI1 | DYNC1LI2 | 0.999 | 0.949 | hein_WMM bioplex (DYNC1LI1) bioplex_WMM boldt youn_WMM hein (DYNC1LI1) gupta_WMM boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_02795 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DYNC1H1 | HuMAP2_02795 HuMAP2_05169 HuMAP2_06616 |
| DYNC1I2 | HuMAP2_02747 HuMAP2_02795 |
| DYNC1LI2 | HuMAP2_02747 HuMAP2_02795 HuMAP2_04880 |
| DYNC1LI1 | HuMAP2_00118 HuMAP2_02747 HuMAP2_02795 |