hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02800

Confidence: Medium High

Genename	Protein Name	Links
CEP162	Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog)	UniProt NCBI
SFN	14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)	UniProt NCBI
PDCD4	Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a)	UniProt NCBI
IQGAP1	Ras GTPase-activating-like protein IQGAP1 (p195)	UniProt NCBI
YWHAH	14-3-3 protein eta (Protein AS1)	UniProt NCBI
YWHAQ	14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)	UniProt NCBI
YWHAE	14-3-3 protein epsilon (14-3-3E)	UniProt NCBI
YWHAG	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-75035	2.09083641306e-12	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
REAC:R-HSA-111447	4.87697936989e-12	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Activation of BAD and translocation to mitochondria
REAC:R-HSA-114452	2.30852101102e-10	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Activation of BH3-only proteins
CORUM:5199	2.87035802876e-09	0.5	YWHAH YWHAG YWHAQ YWHAE	Kinase maturation complex 1
REAC:R-HSA-109606	3.42074911658e-09	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Intrinsic Pathway for Apoptosis
CORUM:5615	1.39443854733e-08	0.5	IQGAP1 YWHAE YWHAQ PDCD4	Emerin complex 52
REAC:R-HSA-1445148	1.67788723747e-08	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Translocation of SLC2A4 (GLUT4) to the plasma membrane
GO:1900740	2.42915188566e-08	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1900739	2.42915188566e-08	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
REAC:R-HSA-5628897	3.86170838641e-08	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	TP53 Regulates Metabolic Genes
GO:0001844	5.42593659574e-08	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
WP:WP179	7.30927831395e-08	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Cell Cycle
KEGG:04110	8.24520709965e-08	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Cell cycle
REAC:R-HSA-5625740	8.33021146523e-08	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	RHO GTPases activate PKNs
WP:WP536	8.67916536805e-08	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Calcium Regulation in the Cardiac Cell
REAC:R-HSA-69473	8.79671668475e-08	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	G2/M DNA damage checkpoint
GO:1901030	1.083663195e-07	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
WP:WP289	1.35280321387e-07	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Myometrial Relaxation and Contraction Pathways
GO:1901028	2.62622334356e-07	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
REAC:R-HSA-195258	3.64340322724e-07	0.75	IQGAP1 YWHAE YWHAH YWHAG SFN YWHAQ	RHO GTPase Effectors
GO:0051204	4.94948622836e-07	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	protein insertion into mitochondrial membrane
GO:0097345	7.79858175868e-07	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	mitochondrial outer membrane permeabilization
GO:1902110	9.64651250877e-07	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902686	1.18288344743e-06	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	mitochondrial outer membrane permeabilization involved in programmed cell death
GO:1902108	1.30588062175e-06	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	regulation of mitochondrial membrane permeability involved in apoptotic process
GO:0035794	1.30588062175e-06	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	positive regulation of mitochondrial membrane permeability
GO:0051205	1.30588062175e-06	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	protein insertion into membrane
GO:1905710	1.43889148912e-06	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	positive regulation of membrane permeability
GO:1903749	1.43889148912e-06	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	positive regulation of establishment of protein localization to mitochondrion
REAC:R-HSA-69481	1.61294267391e-06	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	G2/M Checkpoints
REAC:R-HSA-109581	1.71252274768e-06	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Apoptosis
REAC:R-HSA-5357801	1.87102943214e-06	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Programmed Cell Death
GO:0046902	2.08338591559e-06	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	regulation of mitochondrial membrane permeability
REAC:R-HSA-194315	2.6447410259e-06	0.75	IQGAP1 YWHAE YWHAH YWHAG SFN YWHAQ	Signaling by Rho GTPases
REAC:R-HSA-9614399	2.9697670258e-06	0.375	SFN YWHAQ YWHAG	Regulation of localization of FOXO transcription factors
GO:1903747	3.46319417673e-06	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	regulation of establishment of protein localization to mitochondrion
GO:0090559	3.75116176379e-06	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	regulation of membrane permeability
KEGG:04114	8.2877953212e-06	0.5	YWHAH YWHAG YWHAQ YWHAE	Oocyte meiosis
WP:WP706	1.79525728869e-05	0.5	YWHAH YWHAG YWHAQ YWHAE	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
GO:0008637	2.10272659881e-05	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	apoptotic mitochondrial changes
KEGG:05160	2.17587490026e-05	0.5	YWHAH YWHAG YWHAQ YWHAE	Hepatitis C
REAC:R-HSA-69620	2.43008641553e-05	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Cell Cycle Checkpoints
GO:1905477	2.4806741051e-05	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	positive regulation of protein localization to membrane
KEGG:04390	2.58756624072e-05	0.5	YWHAH YWHAG YWHAQ YWHAE	Hippo signaling pathway
GO:0010822	3.06700561997e-05	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	positive regulation of mitochondrion organization
GO:2001235	5.02570571668e-05	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	positive regulation of apoptotic signaling pathway
GO:0007006	5.26643691987e-05	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	mitochondrial membrane organization
REAC:R-HSA-3700989	6.34254423851e-05	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Transcriptional Regulation by TP53
KEGG:05203	7.95424377416e-05	0.5	YWHAH YWHAG YWHAQ YWHAE	Viral carcinogenesis
GO:0072655	0.000101237303578	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	establishment of protein localization to mitochondrion
GO:0070585	0.000109776082798	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	protein localization to mitochondrion
GO:0010821	0.000167603332803	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	regulation of mitochondrion organization
GO:1905475	0.000173874805144	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	regulation of protein localization to membrane
KEGG:04151	0.000509455935862	0.5	YWHAH YWHAG YWHAQ YWHAE	PI3K-Akt signaling pathway
GO:0043065	0.000528814020866	0.75	YWHAE PDCD4 YWHAH YWHAG SFN YWHAQ	positive regulation of apoptotic process
REAC:R-HSA-9614085	0.000548821623509	0.375	SFN YWHAQ YWHAG	FOXO-mediated transcription
GO:0043068	0.000577376122976	0.75	YWHAE PDCD4 YWHAH YWHAG SFN YWHAQ	positive regulation of programmed cell death
REAC:R-HSA-199991	0.000799602221976	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Membrane Trafficking
GO:0010942	0.000953192857903	0.75	YWHAE PDCD4 YWHAH YWHAG SFN YWHAQ	positive regulation of cell death
REAC:R-HSA-5653656	0.0010405888662	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Vesicle-mediated transport
REAC:R-HSA-1640170	0.00108292913925	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Cell Cycle
MIRNA:hsa-miR-4748	0.00193912540125	0.375	YWHAH PDCD4 YWHAE	hsa-miR-4748
MIRNA:hsa-miR-4464	0.00193912540125	0.375	YWHAH PDCD4 YWHAE	hsa-miR-4464
GO:0006839	0.00198632319966	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	mitochondrial transport
REAC:R-HSA-5620912	0.00243902745158	0.375	YWHAG CEP162 YWHAE	Anchoring of the basal body to the plasma membrane
GO:1903829	0.00337234962474	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	positive regulation of cellular protein localization
GO:2001233	0.00337234962474	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	regulation of apoptotic signaling pathway
GO:0090150	0.00496056272861	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	establishment of protein localization to membrane
GO:1904951	0.00840508837901	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	positive regulation of establishment of protein localization
REAC:R-HSA-212436	0.0132859010078	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Generic Transcription Pathway
WP:000000	0.0134045376724	1.0	YWHAE PDCD4 IQGAP1 YWHAG CEP162 YWHAH SFN YWHAQ	WIKIPATHWAYS
MIRNA:hsa-miR-30e-3p	0.0161775100658	0.375	YWHAH YWHAE YWHAG	hsa-miR-30e-3p
REAC:R-HSA-5617833	0.0196596693296	0.375	YWHAG CEP162 YWHAE	Cilium Assembly
REAC:R-HSA-162582	0.020478873125	0.75	IQGAP1 YWHAE YWHAH YWHAG SFN YWHAQ	Signal Transduction
REAC:R-HSA-73857	0.0224473446481	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	RNA Polymerase II Transcription
MIRNA:hsa-miR-30a-3p	0.0234864318241	0.375	YWHAH YWHAE YWHAG	hsa-miR-30a-3p
CORUM:6730	0.0248670854284	0.125	YWHAG	14-3-3 gamma-CXCR2 complex, unstimulated
CORUM:6729	0.0248670854284	0.125	IQGAP1	IQGAP1-CXCR2 complex
GO:0097190	0.0273235727239	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	apoptotic signaling pathway
GO:1903827	0.0306971650449	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	regulation of cellular protein localization
GO:0008426	0.0378589948753	0.25	SFN YWHAG	protein kinase C inhibitor activity
REAC:R-HSA-74160	0.037866398773	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	Gene expression (Transcription)
GO:0007005	0.0487710786588	0.625	SFN YWHAH YWHAG YWHAQ YWHAE	mitochondrion organization
CORUM:2145	0.0497224828424	0.125	YWHAE	HSF1-YWHAE complex
CORUM:6676	0.0497224828424	0.125	YWHAQ	WWTR1-YWHAQ complex
CORUM:1844	0.0497224828424	0.125	IQGAP1	APC-IQGAP1 complex
CORUM:5189	0.0497224828424	0.125	YWHAQ	YWHAQ-CALM1-CABIN1 complex
GO:0021762	0.0497817121827	0.375	YWHAH YWHAQ YWHAE	substantia nigra development

Edges

Protein 1	Protein 2	Score	Precision	Evidence
YWHAH	YWHAE	1.0	0.949	hein_WMM bioplex_WMM boldt (YWHAE) hein (YWHAH) Malo gupta_WMM fraction boldt_WMM treiber_WMM
YWHAH	YWHAQ	1.0	0.949	hein_WMM bioplex_WMM boldt youn_WMM hein (YWHAH) gupta_WMM fraction boldt_WMM treiber_WMM
YWHAG	YWHAQ	1.0	0.949	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
YWHAH	YWHAG	1.0	0.949	hein_WMM bioplex_WMM boldt youn_WMM hein (YWHAH) Malo gupta_WMM fraction boldt_WMM treiber_WMM
YWHAQ	YWHAE	1.0	0.949	hein_WMM bioplex_WMM Guru boldt (YWHAE) gupta_WMM fraction boldt_WMM treiber_WMM
YWHAG	YWHAE	1.0	0.949	hein_WMM bioplex_WMM boldt (YWHAE) Malo gupta_WMM fraction boldt_WMM treiber_WMM
YWHAQ	IQGAP1	0.988	0.901	bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
IQGAP1	YWHAE	0.988	0.901	boldt gupta_WMM fraction boldt_WMM treiber_WMM
PDCD4	IQGAP1	0.988	0.901	youn (PDCD4) youn_WMM fraction
PDCD4	YWHAE	0.988	0.901	youn (PDCD4) gupta_WMM fraction
PDCD4	YWHAQ	0.988	0.901	youn (PDCD4) youn_WMM gupta_WMM fraction
YWHAH	CEP162	0.067	0.351	bioplex (CEP162) gupta (CEP162) youn_WMM gupta_WMM
SFN	YWHAG	0.063	0.347	hein_WMM bioplex (SFN) bioplex_WMM boldt boldt_WMM treiber_WMM
YWHAH	IQGAP1	0.061	0.339	boldt youn_WMM gupta_WMM fraction boldt_WMM
SFN	YWHAQ	0.056	0.313	hein_WMM bioplex (SFN) bioplex_WMM boldt boldt_WMM treiber_WMM
YWHAG	IQGAP1	0.008	0.041	boldt youn_WMM gupta_WMM fraction boldt_WMM
YWHAG	PDCD4	0.007	0.007	youn_WMM gupta_WMM WMM_only
PDCD4	CEP162	0.007	0.002	gupta_WMM WMM_only
SFN	IQGAP1	0.007	0.005	bioplex_WMM boldt boldt_WMM treiber_WMM
YWHAH	PDCD4	0.007	0.003	youn (PDCD4) youn_WMM gupta_WMM
SFN	CEP162	0.006	0.006	bioplex (CEP162)
YWHAG	CEP162	0.005	0.011	bioplex (CEP162) gupta (CEP162) gupta_WMM
IQGAP1	CEP162	0.005	0.009	hein_WMM youn_WMM gupta_WMM gupta (CEP162)
YWHAQ	CEP162	0.004	0.011	bioplex (CEP162) gupta (CEP162) youn_WMM gupta_WMM
SFN	YWHAE	0.004	0.013	hein_WMM bioplex (SFN) bioplex_WMM boldt fraction boldt_WMM treiber_WMM
YWHAE	CEP162	0.004	0.015	bioplex (CEP162) gupta (CEP162) gupta_WMM boldt_WMM
SFN	YWHAH	0.003	0.011	bioplex_WMM boldt fraction boldt_WMM treiber_WMM

Images

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Complex HuMAP2_02800 has an average edge precision of 0.433 which is ranked 2996 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CEP162	HuMAP2_02800 HuMAP2_04364 HuMAP2_05853 HuMAP2_06113
SFN	HuMAP2_00021 HuMAP2_02042 HuMAP2_02800 HuMAP2_04364 HuMAP2_04745 HuMAP2_06235
PDCD4	HuMAP2_01030 HuMAP2_02558 HuMAP2_02800 HuMAP2_03461 HuMAP2_03474 HuMAP2_04364 HuMAP2_04728 HuMAP2_06654
IQGAP1	HuMAP2_02558 HuMAP2_02800 HuMAP2_03461 HuMAP2_03474 HuMAP2_04364 HuMAP2_06654
YWHAH	HuMAP2_00504 HuMAP2_02558 HuMAP2_02773 HuMAP2_02800 HuMAP2_03461 HuMAP2_04364 HuMAP2_05853 HuMAP2_06654
YWHAQ	HuMAP2_02558 HuMAP2_02773 HuMAP2_02800 HuMAP2_03461 HuMAP2_03474 HuMAP2_04364 HuMAP2_06654
YWHAE	HuMAP2_02558 HuMAP2_02773 HuMAP2_02800 HuMAP2_03461 HuMAP2_03474 HuMAP2_04364 HuMAP2_05956 HuMAP2_06654
YWHAG	HuMAP2_00504 HuMAP2_02558 HuMAP2_02773 HuMAP2_02800 HuMAP2_03461 HuMAP2_04364 HuMAP2_06654

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02800