hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02802
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) | UniProt NCBI |
| RRM1 | Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) | UniProt NCBI |
| FBXO48 | F-box only protein 48 | UniProt NCBI |
| GIPC2 | PDZ domain-containing protein GIPC2 | UniProt NCBI |
| CCDC25 | Coiled-coil domain-containing protein 25 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4584 | 0.000350028616523 | 0.4 | RRM2B RRM1 | Biomarkers for pyrimidine metabolism disorders |
| WP:WP4225 | 0.00045324857597 | 0.4 | RRM2B RRM1 | Pyrimidine metabolism and related diseases |
| WP:WP404 | 0.000569740286986 | 0.4 | RRM2B RRM1 | Nucleotide Metabolism |
| REAC:R-HSA-499943 | 0.00472180750517 | 0.4 | RRM2B RRM1 | Interconversion of nucleotide di- and triphosphates |
| KEGG:00480 | 0.00501742472281 | 0.4 | RRM2B RRM1 | Glutathione metabolism |
| KEGG:00240 | 0.00522578105965 | 0.4 | RRM2B RRM1 | Pyrimidine metabolism |
| WP:WP4022 | 0.0101828011392 | 0.4 | RRM2B RRM1 | Pyrimidine metabolism |
| KEGG:00983 | 0.0108715181024 | 0.4 | RRM2B RRM1 | Drug metabolism - other enzymes |
| GO:0004748 | 0.0135228859698 | 0.4 | RRM2B RRM1 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| GO:0016728 | 0.0135228859698 | 0.4 | RRM2B RRM1 | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor |
| GO:0061731 | 0.0135228859698 | 0.4 | RRM2B RRM1 | ribonucleoside-diphosphate reductase activity |
| KEGG:00230 | 0.0258305316126 | 0.4 | RRM2B RRM1 | Purine metabolism |
| REAC:R-HSA-15869 | 0.0487798927038 | 0.4 | RRM2B RRM1 | Metabolism of nucleotides |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RRM1 | FBXO48 | 0.777 | 0.752 | bioplex (RRM1) bioplex_WMM |
| RRM2B | RRM1 | 0.066 | 0.347 | bioplex (RRM1) bioplex_WMM |
| CCDC25 | RRM1 | 0.064 | 0.348 | bioplex_WMM youn_WMM gupta_WMM fraction |
| GIPC2 | RRM1 | 0.041 | 0.269 | fraction |
| RRM2B | FBXO48 | 0.008 | 0.087 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02802 has an average edge precision of 0.361 which is ranked 3753 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RRM2B | HuMAP2_01536 HuMAP2_02802 HuMAP2_03254 HuMAP2_04276 HuMAP2_04714 HuMAP2_05291 |
| RRM1 | HuMAP2_02802 HuMAP2_03254 HuMAP2_03713 |
| FBXO48 | HuMAP2_02802 HuMAP2_03254 HuMAP2_03713 |
| GIPC2 | HuMAP2_02009 HuMAP2_02802 HuMAP2_03254 |
| CCDC25 | HuMAP2_01558 HuMAP2_02802 HuMAP2_04578 HuMAP2_05568 |