hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02804
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | UniProt NCBI |
| GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | UniProt NCBI |
| GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha (G(i) alpha-3) | UniProt NCBI |
| GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) | UniProt NCBI |
| GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-392170 | 3.80262426659e-13 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | ADP signalling through P2Y purinoceptor 12 |
| REAC:R-HSA-202040 | 1.61336831951e-12 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | G-protein activation |
| REAC:R-HSA-392518 | 2.91267185745e-12 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Signal amplification |
| REAC:R-HSA-6814122 | 1.41214366606e-11 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| REAC:R-HSA-418597 | 2.66362253258e-11 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | G alpha (z) signalling events |
| KEGG:04727 | 1.75833998498e-10 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | GABAergic synapse |
| KEGG:05032 | 1.99895493029e-10 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Morphine addiction |
| REAC:R-HSA-9009391 | 2.19193622817e-10 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Extra-nuclear estrogen signaling |
| WP:WP35 | 2.24215233537e-10 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | G Protein Signaling Pathways |
| KEGG:04713 | 3.05642796836e-10 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Circadian entrainment |
| KEGG:04726 | 4.5204243373e-10 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Serotonergic synapse |
| KEGG:04725 | 4.76879930089e-10 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Cholinergic synapse |
| KEGG:04724 | 5.87380892641e-10 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Glutamatergic synapse |
| REAC:R-HSA-8964315 | 6.64240954906e-10 | 0.8 | GNG5 GNB1 GNG11 GNB2 | G beta:gamma signalling through BTK |
| REAC:R-HSA-111885 | 8.54175316698e-10 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Opioid Signalling |
| REAC:R-HSA-392851 | 8.6857608829e-10 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Prostacyclin signalling through prostacyclin receptor |
| REAC:R-HSA-390466 | 1.07793184337e-09 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Chaperonin-mediated protein folding |
| REAC:R-HSA-418217 | 1.11668064351e-09 | 0.8 | GNG5 GNB1 GNG11 GNB2 | G beta:gamma signalling through PLC beta |
| REAC:R-HSA-8964616 | 1.11668064351e-09 | 0.8 | GNG5 GNB1 GNG11 GNB2 | G beta:gamma signalling through CDC42 |
| WP:WP536 | 1.15644550825e-09 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Calcium Regulation in the Cardiac Cell |
| WP:WP3929 | 1.3662316802e-09 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Chemokine signaling pathway |
| REAC:R-HSA-500657 | 1.41438609596e-09 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Presynaptic function of Kainate receptors |
| KEGG:04926 | 1.48685851061e-09 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Relaxin signaling pathway |
| REAC:R-HSA-391251 | 1.49917343291e-09 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Protein folding |
| KEGG:04728 | 1.55094723952e-09 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Dopaminergic synapse |
| KEGG:04371 | 1.75658358882e-09 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Apelin signaling pathway |
| REAC:R-HSA-392451 | 2.18374366255e-09 | 0.8 | GNG5 GNB1 GNG11 GNB2 | G beta:gamma signalling through PI3Kgamma |
| REAC:R-HSA-428930 | 2.18374366255e-09 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Thromboxane signalling through TP receptor |
| REAC:R-HSA-420092 | 2.18374366255e-09 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Glucagon-type ligand receptors |
| KEGG:04062 | 2.23322702966e-09 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Chemokine signaling pathway |
| KEGG:04723 | 2.41325845499e-09 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Retrograde endocannabinoid signaling |
| REAC:R-HSA-418592 | 2.66887650159e-09 | 0.8 | GNG5 GNB1 GNG11 GNB2 | ADP signalling through P2Y purinoceptor 1 |
| REAC:R-HSA-400042 | 5.45333158978e-09 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Adrenaline,noradrenaline inhibits insulin secretion |
| REAC:R-HSA-451326 | 6.40139272836e-09 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Activation of kainate receptors upon glutamate binding |
| REAC:R-HSA-456926 | 7.46788976858e-09 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Thrombin signalling through proteinase activated receptors (PARs) |
| REAC:R-HSA-397795 | 7.46788976858e-09 | 0.8 | GNG5 GNB1 GNG11 GNB2 | G-protein beta:gamma signalling |
| KEGG:05034 | 7.71177014418e-09 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Alcoholism |
| REAC:R-HSA-163359 | 1.14744433983e-08 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Glucagon signaling in metabolic regulation |
| REAC:R-HSA-977444 | 1.31129440131e-08 | 0.8 | GNG5 GNB1 GNAI3 GNB2 | GABA B receptor activation |
| REAC:R-HSA-991365 | 1.31129440131e-08 | 0.8 | GNG5 GNB1 GNAI3 GNB2 | Activation of GABAB receptors |
| REAC:R-HSA-381676 | 1.90901811802e-08 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| KEGG:05170 | 1.92881579088e-08 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 2.080229575e-08 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Human cytomegalovirus infection |
| REAC:R-HSA-432040 | 2.40770685636e-08 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Vasopressin regulates renal water homeostasis via Aquaporins |
| REAC:R-HSA-445717 | 2.99818273785e-08 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Aquaporin-mediated transport |
| REAC:R-HSA-112314 | 3.16676886926e-08 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-418555 | 3.25936445023e-08 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | G alpha (s) signalling events |
| REAC:R-HSA-977443 | 5.94611734259e-08 | 0.8 | GNG5 GNB1 GNAI3 GNB2 | GABA receptor activation |
| REAC:R-HSA-8939211 | 6.87324836531e-08 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | ESR-mediated signaling |
| REAC:R-HSA-4086398 | 1.06659036688e-07 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Ca2+ pathway |
| REAC:R-HSA-76002 | 1.07739589482e-07 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Platelet activation, signaling and aggregation |
| REAC:R-HSA-112315 | 1.17849597997e-07 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Transmission across Chemical Synapses |
| REAC:R-HSA-9006931 | 1.69628241468e-07 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Signaling by Nuclear Receptors |
| REAC:R-HSA-373080 | 2.03091825402e-07 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Class B/2 (Secretin family receptors) |
| REAC:R-HSA-418594 | 2.38190731555e-07 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | G alpha (i) signalling events |
| REAC:R-HSA-422356 | 3.14615795114e-07 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Regulation of insulin secretion |
| REAC:R-HSA-416482 | 3.96024318077e-07 | 0.8 | GNG5 GNB1 GNG11 GNB2 | G alpha (12/13) signalling events |
| REAC:R-HSA-418346 | 4.92281730711e-07 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Platelet homeostasis |
| REAC:R-HSA-112316 | 9.15035629693e-07 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Neuronal System |
| WP:WP289 | 1.05142095686e-06 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Myometrial Relaxation and Contraction Pathways |
| REAC:R-HSA-163685 | 1.2590474109e-06 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Integration of energy metabolism |
| KEGG:05200 | 1.3832809713e-06 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Pathways in cancer |
| GO:0005834 | 1.82141275099e-06 | 0.8 | GNG5 GNB1 GNG11 GNAI3 | heterotrimeric G-protein complex |
| GO:1905360 | 1.82141275099e-06 | 0.8 | GNG5 GNB1 GNG11 GNAI3 | GTPase complex |
| WP:WP4223 | 2.07293422328e-06 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Ras Signaling |
| REAC:R-HSA-997272 | 2.21544983597e-06 | 0.6 | GNG5 GNB2 GNB1 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| REAC:R-HSA-1296041 | 2.21544983597e-06 | 0.6 | GNG5 GNB2 GNB1 | Activation of G protein gated Potassium channels |
| REAC:R-HSA-1296059 | 2.21544983597e-06 | 0.6 | GNG5 GNB2 GNB1 | G protein gated Potassium channels |
| KEGG:05167 | 3.42876450157e-06 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-416476 | 4.51796469523e-06 | 0.8 | GNG5 GNB1 GNG11 GNB2 | G alpha (q) signalling events |
| REAC:R-HSA-1296065 | 4.80586315819e-06 | 0.6 | GNG5 GNB2 GNB1 | Inwardly rectifying K+ channels |
| REAC:R-HSA-3858494 | 5.0922141532e-06 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Beta-catenin independent WNT signaling |
| KEGG:04014 | 5.31714724072e-06 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Ras signaling pathway |
| REAC:R-HSA-109582 | 8.87476944872e-06 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Hemostasis |
| REAC:R-HSA-388396 | 9.0422143857e-06 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | GPCR downstream signalling |
| REAC:R-HSA-372790 | 1.3647934265e-05 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Signaling by GPCR |
| WP:WP3932 | 1.55793734085e-05 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| CORUM:7199 | 2.0123342217e-05 | 0.4 | GNG11 GNB2 | GNAS-L-GNB2-GNG11 complex |
| CORUM:7036 | 2.0123342217e-05 | 0.4 | GNG5 GNB1 | GNAI1-GNB1-GNG5 complex |
| CORUM:7195 | 2.0123342217e-05 | 0.4 | GNG11 GNB1 | GNAS-L-GNB1-GNG11 complex |
| CORUM:7166 | 2.0123342217e-05 | 0.4 | GNG5 GNB2 | GNAS-L-GNB2-GNG5 complex |
| CORUM:7165 | 2.0123342217e-05 | 0.4 | GNG5 GNB1 | GNAS-L-GNB1-GNG5 complex |
| CORUM:7082 | 2.0123342217e-05 | 0.4 | GNG11 GNB2 | GNAI1-GNB2-GNG11 complex |
| CORUM:7081 | 2.0123342217e-05 | 0.4 | GNG11 GNB1 | GNAI1-GNB1-GNG11 complex |
| CORUM:7037 | 2.0123342217e-05 | 0.4 | GNG5 GNB2 | GNAI1-GNB2-GNG5 complex |
| WP:WP4172 | 2.46316127093e-05 | 0.8 | GNG5 GNB1 GNG11 GNB2 | PI3K-Akt Signaling Pathway |
| REAC:R-HSA-500792 | 2.78971859313e-05 | 0.8 | GNG5 GNB1 GNG11 GNB2 | GPCR ligand binding |
| KEGG:04151 | 3.78166640446e-05 | 0.8 | GNG5 GNB1 GNG11 GNB2 | PI3K-Akt signaling pathway |
| GO:0003924 | 5.9036082881e-05 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | GTPase activity |
| REAC:R-HSA-195721 | 0.000135560445088 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Signaling by WNT |
| GO:0031234 | 0.000164422098058 | 0.8 | GNG5 GNB1 GNG11 GNAI3 | extrinsic component of cytoplasmic side of plasma membrane |
| REAC:R-HSA-1296071 | 0.000167928044622 | 0.6 | GNG5 GNB2 GNB1 | Potassium Channels |
| GO:0019897 | 0.00113692677057 | 0.8 | GNG5 GNB1 GNG11 GNAI3 | extrinsic component of plasma membrane |
| GO:0009898 | 0.001292590007 | 0.8 | GNG5 GNB1 GNG11 GNAI3 | cytoplasmic side of plasma membrane |
| REAC:R-HSA-382551 | 0.00191509203292 | 0.8 | GNG5 GNB1 GNG11 GNB2 | Transport of small molecules |
| GO:0098562 | 0.0023227175406 | 0.8 | GNG5 GNB1 GNG11 GNAI3 | cytoplasmic side of membrane |
| GO:0007186 | 0.00290907799633 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | G protein-coupled receptor signaling pathway |
| REAC:R-HSA-392499 | 0.0039377533293 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Metabolism of proteins |
| GO:0017111 | 0.00425361077725 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | nucleoside-triphosphatase activity |
| GO:0016462 | 0.00595718342043 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | pyrophosphatase activity |
| REAC:R-HSA-162582 | 0.00595743543191 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | Signal Transduction |
| GO:0016818 | 0.00605484060313 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| GO:0016817 | 0.00605484060313 | 1.0 | GNG5 GNB1 GNB2 GNG11 GNAI3 | hydrolase activity, acting on acid anhydrides |
| WP:WP2032 | 0.00688743357746 | 0.4 | GNAI3 GNB1 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| WP:WP2355 | 0.0115135837289 | 0.4 | GNB2 GNB1 | Corticotropin-releasing hormone signaling pathway |
| GO:0019898 | 0.0116598248695 | 0.8 | GNG5 GNB1 GNG11 GNAI3 | extrinsic component of membrane |
| MIRNA:hsa-miR-1-3p | 0.0144936698818 | 0.8 | GNG5 GNB1 GNAI3 GNB2 | hsa-miR-1-3p |
| HP:0000396 | 0.0379116132621 | 0.4 | GNAI3 GNB1 | Overfolded helix |
| HP:0008544 | 0.0457467210618 | 0.4 | GNAI3 GNB1 | Abnormally folded helix |
| GO:0098552 | 0.0464577202339 | 0.8 | GNG5 GNB1 GNG11 GNAI3 | side of membrane |
| CORUM:7097 | 0.0499494897235 | 0.2 | GNB1 | GNAS-L-GNB1-GNG1 complex |
| CORUM:7086 | 0.0499494897235 | 0.2 | GNB1 | GNAI1-GNB1-GNG12 complex |
| CORUM:7015 | 0.0499494897235 | 0.2 | GNB2 | GNAI1-GNB2-GNGT1 complex |
| CORUM:7014 | 0.0499494897235 | 0.2 | GNB1 | GNAI1-GNGT1-GNB1 complex |
| CORUM:1614 | 0.0499494897235 | 0.2 | GNB1 | G protein complex (MCF2, GNB1, GNG2) |
| CORUM:7143 | 0.0499494897235 | 0.2 | GNB2 | GNAS-L-GNB2-GNG1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GNG11 | GNAI3 | 0.83 | 0.778 | bioplex (GNAI3) bioplex_WMM |
| GNAI3 | GNG5 | 0.746 | 0.741 | bioplex (GNAI3) bioplex_WMM |
| GNB1 | GNAI3 | 0.515 | 0.632 | hein_WMM bioplex (GNAI3) bioplex_WMM youn_WMM gupta_WMM |
| GNAI3 | GNB2 | 0.5 | 0.621 | hein_WMM bioplex (GNAI3) bioplex_WMM |
| GNG11 | GNB1 | 0.013 | 0.141 | bioplex (GNG11) bioplex_WMM |
| GNB1 | GNG5 | 0.01 | 0.129 | bioplex_WMM WMM_only boldt_WMM |
| GNG11 | GNG5 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| GNB1 | GNB2 | 0.008 | 0.024 | hein_WMM bioplex_WMM boldt boldt_WMM |
| GNG11 | GNB2 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| GNB2 | GNG5 | 0.005 | 0.007 | bioplex (GNB2) bioplex_WMM boldt_WMM |
Images
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Complex HuMAP2_02804 has an average edge precision of 0.317 which is ranked 4380 out of all 6965 complexes.
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