hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02808
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| APTX | Aprataxin (EC 3.1.11.7) (EC 3.1.12.2) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | UniProt NCBI |
| IFFO1 | Intermediate filament family orphan 1 (Tumor antigen HOM-TES-103) | UniProt NCBI |
| XRCC4 | DNA repair protein XRCC4 (X-ray repair cross-complementing protein 4) | UniProt NCBI |
| LIG4 | DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:348 | 5.02777038712e-06 | 0.5 | XRCC4 LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:354 | 5.02777038712e-06 | 0.5 | XRCC4 LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:352 | 5.02777038712e-06 | 0.5 | XRCC4 LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:206 | 5.02777038712e-06 | 0.5 | XRCC4 LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:344 | 5.02777038712e-06 | 0.5 | XRCC4 LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:345 | 5.02777038712e-06 | 0.5 | XRCC4 LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:359 | 1.50819606993e-05 | 0.5 | XRCC4 LIG4 | DNA ligase IV-XRCC4-XLF complex |
| CORUM:336 | 1.50819606993e-05 | 0.5 | XRCC4 LIG4 | DNA ligase IV-XRCC4-AHNK complex |
| CORUM:350 | 1.50819606993e-05 | 0.5 | XRCC4 LIG4 | DNA ligase IV-XRCC4-PNK complex |
| CORUM:1189 | 0.000105535916717 | 0.5 | XRCC4 LIG4 | DNA double-strand break end-joining complex |
| KEGG:03450 | 0.000156131567372 | 0.5 | XRCC4 LIG4 | Non-homologous end-joining |
| REAC:R-HSA-164843 | 0.000211071833435 | 0.5 | XRCC4 LIG4 | 2-LTR circle formation |
| REAC:R-HSA-162592 | 0.000361772624521 | 0.5 | XRCC4 LIG4 | Integration of provirus |
| REAC:R-HSA-162594 | 0.000914071346391 | 0.5 | XRCC4 LIG4 | Early Phase of HIV Life Cycle |
| HP:0000320 | 0.00149887618857 | 0.5 | XRCC4 LIG4 | Bird-like facies |
| HP:0003683 | 0.00177124047018 | 0.5 | XRCC4 LIG4 | Large beaked nose |
| HP:0004430 | 0.00238393503741 | 0.5 | XRCC4 LIG4 | Severe combined immunodeficiency |
| HP:0005387 | 0.00308721029257 | 0.5 | XRCC4 LIG4 | Combined immunodeficiency |
| GO:0032807 | 0.00811409485621 | 0.5 | XRCC4 LIG4 | DNA ligase IV complex |
| HP:0003220 | 0.0159281461127 | 0.5 | XRCC4 LIG4 | Abnormality of chromosome stability |
| GO:0005958 | 0.0162267366884 | 0.5 | XRCC4 LIG4 | DNA-dependent protein kinase-DNA ligase 4 complex |
| GO:0033152 | 0.0162267366884 | 0.5 | XRCC4 LIG4 | immunoglobulin V(D)J recombination |
| REAC:R-HSA-5693571 | 0.0234490216385 | 0.5 | XRCC4 LIG4 | Nonhomologous End-Joining (NHEJ) |
| HP:0000294 | 0.0373855400094 | 0.5 | XRCC4 LIG4 | Low anterior hairline |
| HP:0004422 | 0.0400245195282 | 0.5 | XRCC4 LIG4 | Biparietal narrowing |
| HP:0100585 | 0.0400245195282 | 0.5 | XRCC4 LIG4 | Telangiectasia of the skin |
| CORUM:213 | 0.0499140284799 | 0.25 | LIG4 | DNA ligase IV-XRCC1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC4 | LIG4 | 1.0 | 0.949 | hein_WMM bioplex (XRCC4) bioplex_WMM |
| APTX | XRCC4 | 1.0 | 0.949 | bioplex (XRCC4) bioplex_WMM |
| XRCC4 | IFFO1 | 0.599 | 0.669 | bioplex (XRCC4) bioplex_WMM |
| APTX | LIG4 | 0.009 | 0.093 | bioplex_WMM WMM_only |
| LIG4 | IFFO1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| APTX | IFFO1 | 0.008 | 0.037 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02808 has an average edge precision of 0.464 which is ranked 2779 out of all 6965 complexes.
Related Complexes