hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02815
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| JAK1 | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) | UniProt NCBI |
| IL4R | Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)] | UniProt NCBI |
| NET1 | Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04658 | 0.00110943942397 | 0.666666666667 | JAK1 IL4R | Th1 and Th2 cell differentiation |
| WP:WP395 | 0.00126905060241 | 0.666666666667 | JAK1 IL4R | IL-4 Signaling Pathway |
| KEGG:04659 | 0.00163069203961 | 0.666666666667 | JAK1 IL4R | Th17 cell differentiation |
| KEGG:04630 | 0.00323398213006 | 0.666666666667 | JAK1 IL4R | JAK-STAT signaling pathway |
| KEGG:04151 | 0.0198175756043 | 0.666666666667 | JAK1 IL4R | PI3K-Akt signaling pathway |
| CORUM:1514 | 0.0249904952816 | 0.333333333333 | IL4R | IL4-IL4R complex |
| REAC:R-HSA-6785807 | 0.0255313065434 | 0.666666666667 | JAK1 IL4R | Interleukin-4 and Interleukin-13 signaling |
| WP:WP3932 | 0.0309522486098 | 0.666666666667 | JAK1 IL4R | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| WP:WP2868 | 0.0357037760272 | 0.333333333333 | JAK1 | TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer |
| WP:WP4172 | 0.0388642175144 | 0.666666666667 | JAK1 IL4R | PI3K-Akt Signaling Pathway |
| KEGG:05200 | 0.0473113658041 | 0.666666666667 | JAK1 IL4R | Pathways in cancer |
| CORUM:1515 | 0.0499776345577 | 0.333333333333 | IL4R | IL4-IL4R-IL2RG complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| JAK1 | IL4R | 0.034 | 0.259 | bioplex (IL4R) bioplex_WMM |
| IL4R | NET1 | 0.033 | 0.253 | bioplex (IL4R) bioplex_WMM |
| JAK1 | NET1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02815 has an average edge precision of 0.172 which is ranked 6505 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| JAK1 | HuMAP2_02049 HuMAP2_02815 HuMAP2_03172 |
| IL4R | HuMAP2_02049 HuMAP2_02815 HuMAP2_03172 |
| NET1 | HuMAP2_02815 HuMAP2_03172 HuMAP2_03785 |