hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02819
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PAPSS1 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] | UniProt NCBI |
| PAPSS2 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2408550 | 5.02777038712e-06 | 1.0 | PAPSS2 PAPSS1 | Metabolism of ingested H2SeO4 and H2SeO3 into H2Se |
| KEGG:00920 | 6.5653894861e-06 | 1.0 | PAPSS2 PAPSS1 | Sulfur metabolism |
| KEGG:00450 | 1.53192421342e-05 | 1.0 | PAPSS2 PAPSS1 | Selenocompound metabolism |
| REAC:R-HSA-174362 | 2.51388519356e-05 | 1.0 | PAPSS2 PAPSS1 | Transport and synthesis of PAPS |
| WP:WP692 | 3.91210398304e-05 | 1.0 | PAPSS2 PAPSS1 | Sulfation Biotransformation Reaction |
| REAC:R-HSA-156584 | 0.000351943927099 | 1.0 | PAPSS2 PAPSS1 | Cytosolic sulfonation of small molecules |
| GO:0004779 | 0.000450823411379 | 1.0 | PAPSS2 PAPSS1 | sulfate adenylyltransferase activity |
| GO:0000103 | 0.000450823411379 | 1.0 | PAPSS2 PAPSS1 | sulfate assimilation |
| GO:0004781 | 0.000450823411379 | 1.0 | PAPSS2 PAPSS1 | sulfate adenylyltransferase (ATP) activity |
| KEGG:00230 | 0.000890704506947 | 1.0 | PAPSS2 PAPSS1 | Purine metabolism |
| GO:0050428 | 0.00676235117068 | 1.0 | PAPSS2 PAPSS1 | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process |
| GO:0034036 | 0.00676235117068 | 1.0 | PAPSS2 PAPSS1 | purine ribonucleoside bisphosphate biosynthetic process |
| REAC:R-HSA-156580 | 0.0074829982595 | 1.0 | PAPSS2 PAPSS1 | Phase II - Conjugation of compounds |
| REAC:R-HSA-1630316 | 0.0102315127378 | 1.0 | PAPSS2 PAPSS1 | Glycosaminoglycan metabolism |
| REAC:R-HSA-2408522 | 0.0107946230212 | 1.0 | PAPSS2 PAPSS1 | Selenoamino acid metabolism |
| REAC:R-HSA-3560796 | 0.0249595281251 | 0.5 | PAPSS2 | Defective PAPSS2 causes SEMD-PA |
| REAC:R-HSA-211859 | 0.0291459849342 | 1.0 | PAPSS2 PAPSS1 | Biological oxidations |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PAPSS2 | PAPSS1 | 1.0 | 0.949 | hein_WMM bioplex (PAPSS1) bioplex_WMM hein (PAPSS1) |
Images
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Complex HuMAP2_02819 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PAPSS1 | HuMAP2_01296 HuMAP2_02819 |
| PAPSS2 | HuMAP2_00324 HuMAP2_01296 HuMAP2_02819 HuMAP2_03575 |