hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02820
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| XRCC1 | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | UniProt NCBI |
| LIG3 | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | UniProt NCBI |
| PNKP | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] | UniProt NCBI |
| POLB | DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:362 | 4.53449095762e-14 | 1.0 | PNKP POLB XRCC1 LIG3 | DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex |
| REAC:R-HSA-5649702 | 1.36034728729e-12 | 1.0 | PNKP POLB XRCC1 LIG3 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
| CORUM:5243 | 2.70078815927e-09 | 0.75 | PNKP XRCC1 LIG3 | XRCC1-LIG3-PNK-TDP1 complex |
| CORUM:1086 | 2.70078815927e-09 | 0.75 | POLB XRCC1 LIG3 | DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| REAC:R-HSA-73933 | 4.74851893082e-09 | 1.0 | PNKP POLB XRCC1 LIG3 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-110381 | 5.40157631853e-09 | 0.75 | POLB XRCC1 LIG3 | Resolution of AP sites via the single-nucleotide replacement pathway |
| CORUM:1085 | 6.75163031135e-09 | 0.75 | POLB XRCC1 LIG3 | DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| REAC:R-HSA-73884 | 2.01866015002e-07 | 1.0 | PNKP POLB XRCC1 LIG3 | Base Excision Repair |
| GO:0006288 | 3.63274304092e-07 | 0.75 | POLB XRCC1 LIG3 | base-excision repair, DNA ligation |
| KEGG:03410 | 1.33274722603e-06 | 0.75 | POLB XRCC1 LIG3 | Base excision repair |
| CORUM:212 | 5.02777038712e-06 | 0.5 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:365 | 5.02777038712e-06 | 0.5 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:363 | 5.02777038712e-06 | 0.5 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| GO:0051103 | 2.03382379613e-05 | 0.75 | POLB XRCC1 LIG3 | DNA ligation involved in DNA repair |
| REAC:R-HSA-73894 | 3.93749583955e-05 | 1.0 | PNKP POLB XRCC1 LIG3 | DNA Repair |
| GO:0006266 | 0.000203300410527 | 0.75 | POLB XRCC1 LIG3 | DNA ligation |
| REAC:R-HSA-5685939 | 0.000452175281072 | 0.5 | XRCC1 LIG3 | HDR through MMEJ (alt-NHEJ) |
| HPA:004030_13 | 0.0024266238785 | 0.75 | PNKP XRCC1 LIG3 | breast; myoepithelial cells[Supported,High] |
| HPA:043020_13 | 0.00298968268698 | 0.75 | PNKP XRCC1 LIG3 | skin 1; fibroblasts[Supported,High] |
| REAC:R-HSA-5696397 | 0.00301045354831 | 0.5 | XRCC1 LIG3 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| GO:0006284 | 0.00305917975424 | 0.75 | POLB XRCC1 LIG3 | base-excision repair |
| HPA:047040_12 | 0.00544296527066 | 0.75 | PNKP XRCC1 LIG3 | soft tissue 1; peripheral nerve[Supported,Medium] |
| HPA:035010_13 | 0.005495872704 | 0.75 | PNKP XRCC1 LIG3 | placenta; decidual cells[Supported,High] |
| HPA:014020_13 | 0.00593145808864 | 0.75 | PNKP XRCC1 LIG3 | endometrium 2; glandular cells[Supported,High] |
| HPA:007030_13 | 0.0066268155894 | 0.75 | PNKP XRCC1 LIG3 | cerebellum; cells in molecular layer[Supported,High] |
| HPA:004020_13 | 0.00730986723989 | 0.75 | PNKP XRCC1 LIG3 | breast; glandular cells[Supported,High] |
| HPA:009010_13 | 0.00743886355825 | 0.75 | PNKP XRCC1 LIG3 | cervix, uterine; glandular cells[Supported,High] |
| HPA:013020_13 | 0.00770136360784 | 0.75 | PNKP XRCC1 LIG3 | endometrium 1; glandular cells[Supported,High] |
| GO:0010836 | 0.00811409485621 | 0.5 | XRCC1 PNKP | negative regulation of protein ADP-ribosylation |
| GO:0098502 | 0.00811409485621 | 0.5 | POLB PNKP | DNA dephosphorylation |
| HPA:044010_13 | 0.0100254167787 | 0.75 | PNKP XRCC1 LIG3 | skin 2; epidermal cells[Supported,High] |
| HPA:004030_03 | 0.0106711364101 | 0.75 | PNKP XRCC1 LIG3 | breast; myoepithelial cells[Uncertain,High] |
| HPA:043020_03 | 0.0119549395508 | 0.75 | PNKP XRCC1 LIG3 | skin 1; fibroblasts[Uncertain,High] |
| HPA:003010_13 | 0.0120439825181 | 0.75 | PNKP XRCC1 LIG3 | bone marrow; hematopoietic cells[Supported,High] |
| HPA:008030_13 | 0.0129586703655 | 0.75 | PNKP XRCC1 LIG3 | cerebral cortex; neuronal cells[Supported,High] |
| HPA:015010_13 | 0.0135289372622 | 0.75 | PNKP XRCC1 LIG3 | epididymis; glandular cells[Supported,High] |
| HPA:007030_03 | 0.01651997263 | 0.75 | PNKP XRCC1 LIG3 | cerebellum; cells in molecular layer[Uncertain,High] |
| HPA:055010_13 | 0.0170761600268 | 0.75 | PNKP XRCC1 LIG3 | thyroid gland; glandular cells[Supported,High] |
| HPA:053020_13 | 0.017188862818 | 0.75 | PNKP XRCC1 LIG3 | testis; cells in seminiferous ducts[Supported,High] |
| HPA:014010_12 | 0.0185798771417 | 0.75 | PNKP XRCC1 LIG3 | endometrium 2; cells in endometrial stroma[Supported,Medium] |
| HPA:035010_03 | 0.0186990413257 | 0.75 | PNKP XRCC1 LIG3 | placenta; decidual cells[Uncertain,High] |
| HPA:047040_11 | 0.0186990413257 | 0.75 | PNKP XRCC1 LIG3 | soft tissue 1; peripheral nerve[Supported,Low] |
| HPA:057010_13 | 0.0188187097484 | 0.75 | PNKP XRCC1 LIG3 | urinary bladder; urothelial cells[Supported,High] |
| REAC:R-HSA-6782210 | 0.0201596117617 | 0.5 | XRCC1 LIG3 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| HPA:032010_13 | 0.0201686361907 | 0.75 | PNKP XRCC1 LIG3 | pancreas; exocrine glandular cells[Supported,High] |
| HPA:018010_13 | 0.0209312173501 | 0.75 | PNKP XRCC1 LIG3 | fallopian tube; glandular cells[Supported,High] |
| HPA:029010_13 | 0.0210601377494 | 0.75 | PNKP XRCC1 LIG3 | nasopharynx; respiratory epithelial cells[Supported,High] |
| HPA:005010_13 | 0.0211895818928 | 0.75 | PNKP XRCC1 LIG3 | bronchus; respiratory epithelial cells[Supported,High] |
| HPA:035020_13 | 0.025175887812 | 0.75 | PNKP XRCC1 LIG3 | placenta; trophoblastic cells[Supported,High] |
| HPA:013010_12 | 0.02561445023 | 0.75 | PNKP XRCC1 LIG3 | endometrium 1; cells in endometrial stroma[Supported,Medium] |
| HPA:048030_12 | 0.026506652998 | 0.75 | PNKP XRCC1 LIG3 | soft tissue 2; fibroblasts[Supported,Medium] |
| HPA:009010_03 | 0.026657319863 | 0.75 | PNKP XRCC1 LIG3 | cervix, uterine; glandular cells[Uncertain,High] |
| HPA:014020_03 | 0.0269603482222 | 0.75 | PNKP XRCC1 LIG3 | endometrium 2; glandular cells[Uncertain,High] |
| HPA:047030_12 | 0.0281952055319 | 0.75 | PNKP XRCC1 LIG3 | soft tissue 1; fibroblasts[Supported,Medium] |
| HPA:037010_13 | 0.0296284087039 | 0.75 | PNKP XRCC1 LIG3 | rectum; glandular cells[Supported,High] |
| REAC:R-HSA-6781827 | 0.0299917015228 | 0.5 | XRCC1 LIG3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| HPA:013020_03 | 0.0307757765426 | 0.75 | PNKP XRCC1 LIG3 | endometrium 1; glandular cells[Uncertain,High] |
| HPA:004020_03 | 0.0319520963736 | 0.75 | PNKP XRCC1 LIG3 | breast; glandular cells[Uncertain,High] |
| HPA:035010_12 | 0.0347513998463 | 0.75 | PNKP XRCC1 LIG3 | placenta; decidual cells[Supported,Medium] |
| REAC:R-HSA-5696399 | 0.0347967852364 | 0.5 | XRCC1 LIG3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| HP:0007141 | 0.0360996225593 | 0.5 | XRCC1 PNKP | Sensorimotor neuropathy |
| HPA:024010_12 | 0.038664676769 | 0.75 | PNKP XRCC1 LIG3 | kidney; cells in glomeruli[Supported,Medium] |
| HPA:047040_02 | 0.0390518301534 | 0.75 | PNKP XRCC1 LIG3 | soft tissue 1; peripheral nerve[Uncertain,Medium] |
| HPA:044010_03 | 0.0394415317177 | 0.75 | PNKP XRCC1 LIG3 | skin 2; epidermal cells[Uncertain,High] |
| HPA:050010_12 | 0.0410259794916 | 0.75 | PNKP XRCC1 LIG3 | spleen; cells in red pulp[Supported,Medium] |
| HP:0000570 | 0.0413775694569 | 0.5 | XRCC1 PNKP | Abnormal saccadic eye movements |
| HPA:027020_12 | 0.0418336999884 | 0.75 | PNKP XRCC1 LIG3 | lung; pneumocytes[Supported,Medium] |
| GO:0006281 | 0.042993565242 | 1.0 | PNKP POLB XRCC1 LIG3 | DNA repair |
| HPA:041010_12 | 0.0438987109299 | 0.75 | PNKP XRCC1 LIG3 | skeletal muscle; myocytes[Supported,Medium] |
| HPA:003010_03 | 0.044531057523 | 0.75 | PNKP XRCC1 LIG3 | bone marrow; hematopoietic cells[Uncertain,High] |
| HPA:011010_12 | 0.0447431662559 | 0.75 | PNKP XRCC1 LIG3 | colon; endothelial cells[Supported,Medium] |
| HPA:007030_12 | 0.0447431662559 | 0.75 | PNKP XRCC1 LIG3 | cerebellum; cells in molecular layer[Supported,Medium] |
| HPA:043020_12 | 0.0458137035926 | 0.75 | PNKP XRCC1 LIG3 | skin 1; fibroblasts[Supported,Medium] |
| HPA:043010_12 | 0.0462466007541 | 0.75 | PNKP XRCC1 LIG3 | skin 1; Langerhans[Supported,Medium] |
| HPA:006020_12 | 0.0462466007541 | 0.75 | PNKP XRCC1 LIG3 | caudate; neuronal cells[Supported,Medium] |
| CORUM:213 | 0.0499140284799 | 0.25 | XRCC1 | DNA ligase IV-XRCC1 complex |
| CORUM:7352 | 0.0499140284799 | 0.25 | LIG3 | PARP1-LIG3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC1 | POLB | 1.0 | 0.949 | hein_WMM bioplex (POLB) bioplex_WMM hein (XRCC1) |
| POLB | LIG3 | 0.999 | 0.949 | hein_WMM bioplex (POLB) bioplex_WMM |
| POLB | PNKP | 0.882 | 0.818 | hein_WMM bioplex (POLB) bioplex_WMM |
| XRCC1 | LIG3 | 0.186 | 0.441 | hein_WMM bioplex_WMM youn_WMM hein (XRCC1) gupta_WMM |
| XRCC1 | PNKP | 0.012 | 0.15 | hein_WMM bioplex_WMM hein (XRCC1) |
| LIG3 | PNKP | 0.008 | 0.081 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02820 has an average edge precision of 0.565 which is ranked 2109 out of all 6965 complexes.
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