hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02821
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BCAT2 | Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT(m)) (EC 2.6.1.42) (Placental protein 18) (PP18) | UniProt NCBI |
| ABHD11 | Protein ABHD11 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 11) (Abhydrolase domain-containing protein 11) (Williams-Beuren syndrome chromosomal region 21 protein) | UniProt NCBI |
| MUC5B | Mucin-5B (MUC-5B) (Cervical mucin) (High molecular weight salivary mucin MG1) (Mucin-5 subtype B, tracheobronchial) (Sublingual gland mucin) | UniProt NCBI |
| YBEY | Endoribonuclease YbeY (EC 3.1.-.-) | UniProt NCBI |
| DMBT1 | Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) | UniProt NCBI |
| PCK2 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) | UniProt NCBI |
| PCK1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0005959 | 0.000346286800202 | 0.285714285714 | PCK1 PCK2 | Impaired gluconeogenesis |
| KEGG:04964 | 0.00187793552306 | 0.285714285714 | PCK1 PCK2 | Proximal tubule bicarbonate reclamation |
| KEGG:00020 | 0.00400477105594 | 0.285714285714 | PCK1 PCK2 | Citrate cycle (TCA cycle) |
| HP:0000799 | 0.0063372308607 | 0.285714285714 | PCK1 PCK2 | Renal steatosis |
| KEGG:00620 | 0.00729284489491 | 0.285714285714 | PCK1 PCK2 | Pyruvate metabolism |
| GO:0004611 | 0.00946729163895 | 0.285714285714 | PCK1 PCK2 | phosphoenolpyruvate carboxykinase activity |
| GO:0046327 | 0.00946729163895 | 0.285714285714 | PCK1 PCK2 | glycerol biosynthetic process from pyruvate |
| GO:0019543 | 0.00946729163895 | 0.285714285714 | PCK1 PCK2 | propionate catabolic process |
| GO:0019541 | 0.00946729163895 | 0.285714285714 | PCK1 PCK2 | propionate metabolic process |
| GO:0004613 | 0.00946729163895 | 0.285714285714 | PCK1 PCK2 | phosphoenolpyruvate carboxykinase (GTP) activity |
| REAC:R-HSA-70263 | 0.0136873957341 | 0.285714285714 | PCK1 PCK2 | Gluconeogenesis |
| KEGG:00010 | 0.0191181203407 | 0.285714285714 | PCK1 PCK2 | Glycolysis / Gluconeogenesis |
| WP:WP3942 | 0.0194028583033 | 0.285714285714 | PCK1 PCK2 | PPAR signaling pathway |
| KEGG:04920 | 0.019730410569 | 0.285714285714 | PCK1 PCK2 | Adipocytokine signaling pathway |
| KEGG:03320 | 0.0242823355935 | 0.285714285714 | PCK1 PCK2 | PPAR signaling pathway |
| KEGG:04970 | 0.0263752467347 | 0.285714285714 | MUC5B DMBT1 | Salivary secretion |
| GO:0071549 | 0.0283955176165 | 0.285714285714 | PCK1 PCK2 | cellular response to dexamethasone stimulus |
| GO:0071548 | 0.0283955176165 | 0.285714285714 | PCK1 PCK2 | response to dexamethasone |
| KEGG:04922 | 0.0443092098146 | 0.285714285714 | PCK1 PCK2 | Glucagon signaling pathway |
| KEGG:04931 | 0.0499845901868 | 0.285714285714 | PCK1 PCK2 | Insulin resistance |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PCK2 | PCK1 | 0.523 | 0.633 | bioplex (PCK2) bioplex_WMM |
| PCK2 | BCAT2 | 0.26 | 0.481 | bioplex_WMM fraction |
| YBEY | BCAT2 | 0.128 | 0.399 | bioplex (YBEY) bioplex_WMM |
| PCK1 | BCAT2 | 0.064 | 0.349 | fraction |
| PCK2 | DMBT1 | 0.028 | 0.232 | bioplex (PCK2) bioplex_WMM |
| PCK2 | MUC5B | 0.026 | 0.216 | bioplex (PCK2) bioplex_WMM |
| ABHD11 | YBEY | 0.022 | 0.209 | bioplex (YBEY) bioplex_WMM |
| MUC5B | DMBT1 | 0.017 | 0.173 | bioplex_WMM WMM_only treiber_WMM |
| PCK1 | DMBT1 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| PCK1 | MUC5B | 0.008 | 0.06 | bioplex_WMM WMM_only |
| PCK2 | ABHD11 | 0.004 | 0.008 | bioplex_WMM fraction |
| PCK2 | YBEY | 0.004 | 0.009 | bioplex (YBEY) bioplex_WMM |
| ABHD11 | BCAT2 | 0.004 | 0.015 | bioplex_WMM fraction |
| PCK1 | ABHD11 | 0.003 | 0.019 | fraction |
Images
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Complex HuMAP2_02821 has an average edge precision of 0.205 which is ranked 6114 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BCAT2 | HuMAP2_02821 HuMAP2_05072 |
| ABHD11 | HuMAP2_02157 HuMAP2_02821 HuMAP2_03124 HuMAP2_04660 HuMAP2_05072 HuMAP2_05726 |
| MUC5B | HuMAP2_02821 HuMAP2_05455 HuMAP2_06200 |
| YBEY | HuMAP2_02157 HuMAP2_02821 HuMAP2_03124 HuMAP2_04660 HuMAP2_05072 HuMAP2_05726 |
| DMBT1 | HuMAP2_02821 HuMAP2_06200 |
| PCK2 | HuMAP2_00780 HuMAP2_02187 HuMAP2_02821 HuMAP2_06200 |
| PCK1 | HuMAP2_00780 HuMAP2_02821 HuMAP2_03122 HuMAP2_04124 HuMAP2_06375 HuMAP2_06449 |