hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02822
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PER1 | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | UniProt NCBI |
| CRY2 | Cryptochrome-2 | UniProt NCBI |
| CRY1 | Cryptochrome-1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04710 | 1.09884462513e-07 | 1.0 | CRY1 CRY2 PER1 | Circadian rhythm |
| WP:WP3298 | 2.89524467535e-07 | 1.0 | CRY1 CRY2 PER1 | Melatonin metabolism and effects |
| WP:WP410 | 7.39430675706e-07 | 1.0 | CRY1 CRY2 PER1 | Exercise-induced Circadian Regulation |
| GO:2000323 | 1.81637152046e-06 | 1.0 | CRY1 CRY2 PER1 | negative regulation of glucocorticoid receptor signaling pathway |
| GO:2000322 | 1.81637152046e-06 | 1.0 | CRY1 CRY2 PER1 | regulation of glucocorticoid receptor signaling pathway |
| GO:0042921 | 1.08982291228e-05 | 1.0 | CRY1 CRY2 PER1 | glucocorticoid receptor signaling pathway |
| GO:0031958 | 1.08982291228e-05 | 1.0 | CRY1 CRY2 PER1 | corticosteroid receptor signaling pathway |
| REAC:R-HSA-400253 | 1.96383930727e-05 | 1.0 | CRY1 CRY2 PER1 | Circadian Clock |
| WP:WP3594 | 4.47986780111e-05 | 1.0 | CRY1 CRY2 PER1 | Circadian rhythm related genes |
| GO:0043153 | 7.41079580349e-05 | 1.0 | CRY1 CRY2 PER1 | entrainment of circadian clock by photoperiod |
| GO:0009648 | 8.80032001664e-05 | 1.0 | CRY1 CRY2 PER1 | photoperiodism |
| GO:0009649 | 0.000120788706111 | 1.0 | CRY1 CRY2 PER1 | entrainment of circadian clock |
| GO:0033144 | 0.000265644334868 | 1.0 | CRY1 CRY2 PER1 | negative regulation of intracellular steroid hormone receptor signaling pathway |
| GO:0071483 | 0.00135247023414 | 0.666666666667 | CRY1 CRY2 | cellular response to blue light |
| GO:0009785 | 0.00135247023414 | 0.666666666667 | CRY1 CRY2 | blue light signaling pathway |
| GO:0009637 | 0.00135247023414 | 0.666666666667 | CRY1 CRY2 | response to blue light |
| GO:0009882 | 0.00135247023414 | 0.666666666667 | CRY1 CRY2 | blue light photoreceptor activity |
| GO:0032922 | 0.00251749092736 | 1.0 | CRY1 CRY2 PER1 | circadian regulation of gene expression |
| GO:0033143 | 0.00295242108794 | 1.0 | CRY1 CRY2 PER1 | regulation of intracellular steroid hormone receptor signaling pathway |
| GO:0042752 | 0.00746165420606 | 1.0 | CRY1 CRY2 PER1 | regulation of circadian rhythm |
| GO:0030518 | 0.0155935495032 | 1.0 | CRY1 CRY2 PER1 | intracellular steroid hormone receptor signaling pathway |
| GO:0043401 | 0.0175207196864 | 1.0 | CRY1 CRY2 PER1 | steroid hormone mediated signaling pathway |
| GO:0071383 | 0.0310032822085 | 1.0 | CRY1 CRY2 PER1 | cellular response to steroid hormone stimulus |
| GO:0007623 | 0.033252767518 | 1.0 | CRY1 CRY2 PER1 | circadian rhythm |
| GO:0009755 | 0.0389190292946 | 1.0 | CRY1 CRY2 PER1 | hormone-mediated signaling pathway |
| GO:0048511 | 0.047104416733 | 1.0 | CRY1 CRY2 PER1 | rhythmic process |
| GO:0014823 | 0.0486736709081 | 0.666666666667 | CRY1 CRY2 | response to activity |
| GO:0009881 | 0.0486736709081 | 0.666666666667 | CRY1 CRY2 | photoreceptor activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CRY1 | PER1 | 0.998 | 0.944 | hein_WMM bioplex (CRY1,PER1) bioplex_WMM hein (CRY1) |
| CRY2 | CRY1 | 0.996 | 0.929 | hein_WMM bioplex (CRY1) bioplex_WMM |
| CRY2 | PER1 | 0.011 | 0.148 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02822 has an average edge precision of 0.674 which is ranked 1494 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PER1 | HuMAP2_02639 HuMAP2_02822 HuMAP2_03989 HuMAP2_05794 HuMAP2_06686 |
| CRY2 | HuMAP2_02639 HuMAP2_02822 HuMAP2_06178 HuMAP2_06686 |
| CRY1 | HuMAP2_02639 HuMAP2_02822 HuMAP2_05794 HuMAP2_06178 HuMAP2_06686 |