hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02823
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ERCC4 | DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) | UniProt NCBI |
| XPA | DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) | UniProt NCBI |
| CUTC | Copper homeostasis protein cutC homolog | UniProt NCBI |
| POC1B | POC1 centriolar protein homolog B (Pix1) (Proteome of centriole protein 1B) (WD repeat-containing protein 51B) | UniProt NCBI |
| GALNT4 | Polypeptide N-acetylgalactosaminyltransferase 4 (EC 2.4.1.41) (Polypeptide GalNAc transferase 4) (GalNAc-T4) (pp-GaNTase 4) (Protein-UDP acetylgalactosaminyltransferase 4) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4) | UniProt NCBI |
| EDF1 | Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1) | UniProt NCBI |
| ZNF598 | E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:531 | 2.51655344529e-05 | 0.333333333333 | ERCC4 XPA | XPA-ERCC1-ERCC4 complex |
| HP:0010649 | 0.00210158306671 | 0.333333333333 | ERCC4 XPA | Flat nasal alae |
| HP:0009755 | 0.00495018352279 | 0.333333333333 | ERCC4 XPA | Ankyloblepharon |
| HP:0003079 | 0.00495018352279 | 0.333333333333 | ERCC4 XPA | Defective DNA repair after ultraviolet radiation damage |
| KEGG:03420 | 0.00587890830807 | 0.333333333333 | ERCC4 XPA | Nucleotide excision repair |
| GO:1901255 | 0.00676235117068 | 0.333333333333 | ERCC4 XPA | nucleotide-excision repair involved in interstrand cross-link repair |
| HP:0001029 | 0.00682280818411 | 0.333333333333 | ERCC4 XPA | Poikiloderma |
| HP:0003254 | 0.00787106080828 | 0.333333333333 | ERCC4 XPA | Abnormality of DNA repair |
| HP:0000524 | 0.0128094019441 | 0.333333333333 | ERCC4 XPA | Conjunctival telangiectasia |
| HP:0000621 | 0.0128094019441 | 0.333333333333 | ERCC4 XPA | Entropion |
| HP:0008054 | 0.0172946302375 | 0.333333333333 | ERCC4 XPA | Abnormal morphology of the conjunctival vasculature |
| REAC:R-HSA-5696400 | 0.0180541440856 | 0.333333333333 | ERCC4 XPA | Dual Incision in GG-NER |
| HP:0000613 | 0.0187800119955 | 0.5 | ERCC4 XPA POC1B | Photophobia |
| REAC:R-HSA-5696395 | 0.019874448248 | 0.333333333333 | ERCC4 XPA | Formation of Incision Complex in GG-NER |
| GO:0000110 | 0.020283420769 | 0.333333333333 | ERCC4 XPA | nucleotide-excision repair factor 1 complex |
| HP:0004493 | 0.0243148377528 | 0.333333333333 | ERCC4 XPA | Craniofacial hyperostosis |
| HP:0001059 | 0.0262553193116 | 0.333333333333 | ERCC4 XPA | Pterygium |
| HP:0100579 | 0.0370683023611 | 0.333333333333 | ERCC4 XPA | Mucosal telangiectasiae |
| REAC:R-HSA-6782135 | 0.0455991929544 | 0.333333333333 | ERCC4 XPA | Dual incision in TC-NER |
| HP:0100012 | 0.0470489782673 | 0.333333333333 | ERCC4 XPA | Neoplasm of the eye |
| HP:0012740 | 0.0497285764978 | 0.333333333333 | ERCC4 XPA | Papilloma |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GALNT4 | POC1B | 1.0 | 0.949 | bioplex (POC1B) bioplex_WMM |
| ZNF598 | POC1B | 0.176 | 0.435 | bioplex (POC1B) bioplex_WMM youn_WMM gupta_WMM |
| EDF1 | ZNF598 | 0.035 | 0.264 | youn_WMM gupta_WMM fraction |
| ZNF598 | ERCC4 | 0.029 | 0.23 | youn_WMM gupta_WMM fraction |
| ERCC4 | XPA | 0.028 | 0.229 | bioplex (XPA) bioplex_WMM |
| EDF1 | CUTC | 0.02 | 0.185 | youn_WMM fraction |
| ZNF598 | GALNT4 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| EDF1 | POC1B | 0.007 | 0.0 | gupta_WMM WMM_only |
| ZNF598 | CUTC | 0.003 | 0.007 | fraction |
| EDF1 | ERCC4 | 0.0 | 0.001 | youn_WMM fraction |
Images
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Complex HuMAP2_02823 has an average edge precision of 0.238 which is ranked 5551 out of all 6965 complexes.
Related Complexes