hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02825
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) | UniProt NCBI |
| PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) | UniProt NCBI |
| PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | UniProt NCBI |
| PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma3) (AMPK subunit gamma-3) | UniProt NCBI |
| PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2) | UniProt NCBI |
| PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) | UniProt NCBI |
| PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9619483 | 1.79667263456e-18 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Activation of AMPK downstream of NMDARs |
| WP:WP3965 | 1.95511381034e-18 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Lipid Metabolism Pathway |
| REAC:R-HSA-9613354 | 2.16374818218e-18 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 | Lipophagy |
| KEGG:04710 | 2.53937499856e-18 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Circadian rhythm |
| REAC:R-HSA-380972 | 6.14651164454e-18 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Energy dependent regulation of mTOR by LKB1-AMPK |
| REAC:R-HSA-2151209 | 6.49087078481e-18 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation |
| WP:WP1471 | 1.11036805512e-17 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Target Of Rapamycin (TOR) Signaling |
| GO:0004679 | 2.31084003444e-17 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG1 PRKAA1 | AMP-activated protein kinase activity |
| WP:WP1541 | 7.49318619048e-17 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Energy Metabolism |
| REAC:R-HSA-165159 | 7.98445224607e-17 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | mTOR signalling |
| WP:WP4539 | 1.03847875281e-16 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Synaptic signaling pathways associated with autism spectrum disorder |
| KEGG:04213 | 3.77327520401e-16 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Longevity regulating pathway - multiple species |
| REAC:R-HSA-9613829 | 3.86614097777e-16 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 | Chaperone Mediated Autophagy |
| KEGG:04920 | 1.0107131477e-15 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Adipocytokine signaling pathway |
| WP:WP1403 | 1.02576632224e-15 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | AMP-activated Protein Kinase (AMPK) Signaling |
| WP:WP1982 | 1.28595485751e-15 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| KEGG:05410 | 5.65740008112e-15 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Hypertrophic cardiomyopathy (HCM) |
| KEGG:04211 | 6.1854240887e-15 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Longevity regulating pathway |
| REAC:R-HSA-438064 | 8.45816882594e-15 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Post NMDA receptor activation events |
| WP:WP4540 | 9.64868241803e-15 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Pathways Regulating Hippo Signaling |
| REAC:R-HSA-5628897 | 1.64907641161e-14 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | TP53 Regulates Metabolic Genes |
| KEGG:04922 | 1.93924187821e-14 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Glucagon signaling pathway |
| REAC:R-HSA-9615710 | 2.28496570386e-14 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 | Microautophagy |
| REAC:R-HSA-442755 | 2.35125498163e-14 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Activation of NMDA receptors and postsynaptic events |
| WP:WP4321 | 2.64320489087e-14 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Thermogenesis |
| KEGG:04931 | 3.0045566353e-14 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Insulin resistance |
| REAC:R-HSA-1632852 | 3.03336504112e-14 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Macroautophagy |
| REAC:R-HSA-6804756 | 4.20169968528e-14 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Regulation of TP53 Activity through Phosphorylation |
| KEGG:04152 | 5.89424514773e-14 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | AMPK signaling pathway |
| KEGG:04068 | 6.694557044e-14 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | FoxO signaling pathway |
| REAC:R-HSA-9612973 | 1.02854565252e-13 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Autophagy |
| KEGG:04371 | 1.22472003933e-13 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Apelin signaling pathway |
| WP:WP3915 | 1.24296055056e-13 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Angiopoietin Like Protein 8 Regulatory Pathway |
| KEGG:04910 | 1.29737292302e-13 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Insulin signaling pathway |
| KEGG:04932 | 2.02394279178e-13 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Non-alcoholic fatty liver disease (NAFLD) |
| KEGG:04921 | 2.2522837785e-13 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Oxytocin signaling pathway |
| WP:WP4396 | 2.53962762775e-13 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Nonalcoholic fatty liver disease |
| KEGG:04530 | 3.75553173682e-13 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Tight junction |
| REAC:R-HSA-5633007 | 2.11456205093e-12 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Regulation of TP53 Activity |
| REAC:R-HSA-112314 | 4.58485263666e-12 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Neurotransmitter receptors and postsynaptic signal transmission |
| KEGG:04714 | 5.08021233854e-12 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Thermogenesis |
| REAC:R-HSA-1445148 | 8.42897445322e-12 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| GO:0031588 | 9.63047224659e-12 | 0.714285714286 | PRKAB2 PRKAG1 PRKAB1 PRKAG2 PRKAA1 | nucleotide-activated protein kinase complex |
| REAC:R-HSA-112315 | 2.91371280113e-11 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Transmission across Chemical Synapses |
| REAC:R-HSA-1592230 | 4.16857610452e-11 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 | Mitochondrial biogenesis |
| GO:0016241 | 3.40981561528e-10 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | regulation of macroautophagy |
| REAC:R-HSA-112316 | 5.19033605656e-10 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Neuronal System |
| REAC:R-HSA-3700989 | 5.99120774917e-10 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Transcriptional Regulation by TP53 |
| GO:1901796 | 7.56587227283e-10 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | regulation of signal transduction by p53 class mediator |
| GO:0007050 | 2.37092508532e-09 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | cell cycle arrest |
| CORUM:6154 | 3.38154272427e-09 | 0.428571428571 | PRKAB2 PRKAA1 PRKAG1 | PRKAA1-PRKAB2-PRKAG1 complex |
| CORUM:6155 | 3.38154272427e-09 | 0.428571428571 | PRKAB2 PRKAG1 PRKAA2 | PRKAA2-PRKAB2-PRKAG1 complex |
| CORUM:6153 | 3.38154272427e-09 | 0.428571428571 | PRKAB2 PRKAA2 PRKAG3 | PRKAA2-PRKAB2-PRKAG3 complex |
| REAC:R-HSA-8953897 | 6.50126875652e-09 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Cellular responses to external stimuli |
| GO:0072331 | 9.86120406489e-09 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | signal transduction by p53 class mediator |
| GO:0016236 | 2.04292132032e-08 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | macroautophagy |
| GO:0010506 | 2.47301342996e-08 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | regulation of autophagy |
| REAC:R-HSA-1852241 | 4.72070793804e-08 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 | Organelle biogenesis and maintenance |
| WP:WP3934 | 2.83706372624e-07 | 0.428571428571 | PRKAG1 PRKAB1 PRKAA1 | Leptin and adiponectin |
| GO:0006914 | 4.37991706361e-07 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | autophagy |
| GO:0061919 | 4.37991706361e-07 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | process utilizing autophagic mechanism |
| REAC:R-HSA-163680 | 5.94732974666e-07 | 0.428571428571 | PRKAB2 PRKAA2 PRKAG2 | AMPK inhibits chREBP transcriptional activation activity |
| CORUM:6888 | 1.22815598808e-06 | 0.428571428571 | PRKAG1 PRKAB1 PRKAA1 | v-ATPase-Ragulator-AXIN/LKB1-AMPK complex |
| REAC:R-HSA-212436 | 1.27537157982e-06 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Generic Transcription Pathway |
| GO:0045786 | 2.08857571006e-06 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | negative regulation of cell cycle |
| REAC:R-HSA-73857 | 2.73975723867e-06 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | RNA Polymerase II Transcription |
| REAC:R-HSA-200425 | 3.0343270142e-06 | 0.428571428571 | PRKAB2 PRKAA2 PRKAG2 | Import of palmitoyl-CoA into the mitochondrial matrix |
| WP:WP4206 | 3.84177292062e-06 | 0.428571428571 | PRKAG1 PRKAB1 PRKAA1 | Hereditary leiomyomatosis and renal cell carcinoma pathway |
| REAC:R-HSA-199991 | 3.8900451489e-06 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 5.36316718014e-06 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 | Vesicle-mediated transport |
| REAC:R-HSA-74160 | 5.89406198727e-06 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Gene expression (Transcription) |
| GO:1902911 | 6.67695565395e-06 | 0.714285714286 | PRKAB2 PRKAG1 PRKAB1 PRKAG2 PRKAA1 | protein kinase complex |
| GO:0031329 | 1.86643581985e-05 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | regulation of cellular catabolic process |
| GO:0009894 | 5.36111558553e-05 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | regulation of catabolic process |
| GO:0004674 | 7.37008656254e-05 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG1 PRKAA1 | protein serine/threonine kinase activity |
| REAC:R-HSA-162582 | 0.0001152718438 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | Signal Transduction |
| GO:0051726 | 0.000143893948854 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | regulation of cell cycle |
| GO:0006853 | 0.000380900357231 | 0.428571428571 | PRKAB2 PRKAA2 PRKAG2 | carnitine shuttle |
| GO:0004672 | 0.00046153489261 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG1 PRKAA1 | protein kinase activity |
| GO:0006110 | 0.000537283108697 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | regulation of glycolytic process |
| GO:0022402 | 0.000570238264329 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | cell cycle process |
| GO:0043470 | 0.000730443752297 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | regulation of carbohydrate catabolic process |
| GO:0061695 | 0.000737359830084 | 0.714285714286 | PRKAB2 PRKAG1 PRKAB1 PRKAG2 PRKAA1 | transferase complex, transferring phosphorus-containing groups |
| GO:0016773 | 0.00127532367729 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG1 PRKAA1 | phosphotransferase activity, alcohol group as acceptor |
| REAC:R-HSA-163685 | 0.00153796376749 | 0.428571428571 | PRKAB2 PRKAA2 PRKAG2 | Integration of energy metabolism |
| GO:1902001 | 0.001775386605 | 0.428571428571 | PRKAB2 PRKAA2 PRKAG2 | fatty acid transmembrane transport |
| GO:1902531 | 0.0017816451003 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | regulation of intracellular signal transduction |
| GO:1900542 | 0.00178932980587 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | regulation of purine nucleotide metabolic process |
| GO:0007049 | 0.00190142502119 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | cell cycle |
| GO:0006140 | 0.00196423913453 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | regulation of nucleotide metabolic process |
| GO:0016301 | 0.00211480680865 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG1 PRKAA1 | kinase activity |
| GO:1903578 | 0.00235209893628 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | regulation of ATP metabolic process |
| GO:0006096 | 0.00245741336962 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | glycolytic process |
| GO:0006757 | 0.00256621622647 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | ATP generation from ADP |
| GO:0046031 | 0.0027945908108 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | ADP metabolic process |
| GO:0009135 | 0.00303783780058 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | purine nucleoside diphosphate metabolic process |
| GO:0009179 | 0.00303783780058 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | purine ribonucleoside diphosphate metabolic process |
| GO:0009185 | 0.00329658494977 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | ribonucleoside diphosphate metabolic process |
| GO:0062012 | 0.00331320603426 | 0.714285714286 | PRKAB2 PRKAA2 PRKAG1 PRKAA1 PRKAG2 | regulation of small molecule metabolic process |
| GO:0006165 | 0.00343197070901 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | nucleoside diphosphate phosphorylation |
| GO:0046939 | 0.00357147263372 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | nucleotide phosphorylation |
| GO:0060089 | 0.00376551811965 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG1 PRKAA1 | molecular transducer activity |
| GO:0009132 | 0.00433362278423 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | nucleoside diphosphate metabolic process |
| REAC:R-HSA-8978868 | 0.00603625037995 | 0.428571428571 | PRKAB2 PRKAA2 PRKAG2 | Fatty acid metabolism |
| GO:0016772 | 0.00651861911974 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG1 PRKAA1 | transferase activity, transferring phosphorus-containing groups |
| GO:0043467 | 0.00665529116898 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | regulation of generation of precursor metabolites and energy |
| GO:0006090 | 0.00811462400483 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | pyruvate metabolic process |
| GO:0046890 | 0.0101054812095 | 0.571428571429 | PRKAB2 PRKAA2 PRKAA1 PRKAG2 | regulation of lipid biosynthetic process |
| GO:0006109 | 0.0110619448331 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | regulation of carbohydrate metabolic process |
| GO:0042304 | 0.0142076090165 | 0.428571428571 | PRKAB2 PRKAA2 PRKAG2 | regulation of fatty acid biosynthetic process |
| WP:WP4286 | 0.0158774380881 | 0.285714285714 | PRKAB2 PRKAB1 | Genotoxicity pathway |
| GO:0016052 | 0.0187784910979 | 0.571428571429 | PRKAG2 PRKAA2 PRKAA1 PRKAG1 | carbohydrate catabolic process |
| GO:0044248 | 0.0200591281071 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | cellular catabolic process |
| WP:WP2034 | 0.0267680695584 | 0.285714285714 | PRKAA2 PRKAA1 | Leptin signaling pathway |
| GO:1904428 | 0.0283955176165 | 0.285714285714 | PRKAA2 PRKAA1 | negative regulation of tubulin deacetylation |
| GO:0032365 | 0.0288395886243 | 0.428571428571 | PRKAB2 PRKAA2 PRKAG2 | intracellular lipid transport |
| GO:0015909 | 0.0288395886243 | 0.428571428571 | PRKAB2 PRKAA2 PRKAG2 | long-chain fatty acid transport |
| GO:0019901 | 0.0298914161514 | 0.714285714286 | PRKAB2 PRKAG3 PRKAG1 PRKAB1 PRKAG2 | protein kinase binding |
| GO:0032787 | 0.0332011588596 | 0.714285714286 | PRKAB2 PRKAA2 PRKAG1 PRKAA1 PRKAG2 | monocarboxylic acid metabolic process |
| GO:0035556 | 0.0364825715723 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | intracellular signal transduction |
| WP:000000 | 0.0394625231882 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | WIKIPATHWAYS |
| CORUM:0000000 | 0.0437772681198 | 0.857142857143 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG1 PRKAA1 | CORUM root |
| GO:0009056 | 0.0452806546755 | 1.0 | PRKAA2 PRKAB1 PRKAG3 PRKAB2 PRKAG2 PRKAG1 PRKAA1 | catabolic process |
| CORUM:771 | 0.0499886427319 | 0.142857142857 | PRKAA1 | NDPKA-AMPKalpha1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRKAA1 | PRKAG1 | 1.0 | 0.949 | hein_WMM bioplex (PRKAG1) bioplex_WMM youn_WMM hein (PRKAA1) gupta_WMM boldt_WMM |
| PRKAB1 | PRKAG1 | 1.0 | 0.949 | hein_WMM bioplex (PRKAB1,PRKAG1) bioplex_WMM youn_WMM gupta_WMM |
| PRKAA2 | PRKAG1 | 0.999 | 0.949 | bioplex (PRKAG1) bioplex_WMM youn_WMM gupta_WMM |
| PRKAB2 | PRKAG1 | 0.998 | 0.944 | hein_WMM bioplex (PRKAB2,PRKAG1) bioplex_WMM |
| PRKAB2 | PRKAA1 | 0.993 | 0.918 | hein_WMM bioplex (PRKAB2) bioplex_WMM Guru hein (PRKAA1) fraction |
| PRKAB1 | PRKAG2 | 0.976 | 0.892 | bioplex (PRKAB1,PRKAG2) bioplex_WMM youn_WMM gupta_WMM |
| PRKAB1 | PRKAA1 | 0.925 | 0.843 | hein_WMM bioplex (PRKAB1) bioplex_WMM Guru youn_WMM hein (PRKAA1) gupta_WMM fraction |
| PRKAB2 | PRKAG2 | 0.876 | 0.81 | bioplex (PRKAB2,PRKAG2) bioplex_WMM |
| PRKAA1 | PRKAG2 | 0.69 | 0.715 | bioplex (PRKAG2) bioplex_WMM youn_WMM gupta_WMM |
| PRKAA2 | PRKAG2 | 0.649 | 0.687 | bioplex (PRKAG2) bioplex_WMM |
| PRKAB1 | PRKAA2 | 0.478 | 0.611 | bioplex (PRKAB1) bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| PRKAB2 | PRKAA2 | 0.238 | 0.47 | bioplex (PRKAB2) bioplex_WMM |
| PRKAB1 | PRKAB2 | 0.215 | 0.464 | hein_WMM bioplex (PRKAB1) bioplex_WMM |
| PRKAB2 | PRKAG3 | 0.035 | 0.261 | bioplex (PRKAG3) bioplex_WMM |
| PRKAB1 | PRKAG3 | 0.029 | 0.23 | bioplex (PRKAG3) bioplex_WMM |
| PRKAA1 | PRKAA2 | 0.019 | 0.185 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PRKAA1 | PRKAG3 | 0.019 | 0.185 | bioplex (PRKAG3) bioplex_WMM |
| PRKAA2 | PRKAG3 | 0.015 | 0.15 | bioplex (PRKAG3) bioplex_WMM |
| PRKAG1 | PRKAG2 | 0.012 | 0.146 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_02825 has an average edge precision of 0.598 which is ranked 1952 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRKAA2 | HuMAP2_00168 HuMAP2_02825 HuMAP2_03872 HuMAP2_05529 |
| PRKAB1 | HuMAP2_00168 HuMAP2_02825 HuMAP2_03872 |
| PRKAA1 | HuMAP2_00168 HuMAP2_02825 HuMAP2_03872 HuMAP2_05529 |
| PRKAG3 | HuMAP2_02825 |
| PRKAB2 | HuMAP2_00168 HuMAP2_02825 HuMAP2_03872 |
| PRKAG2 | HuMAP2_00168 HuMAP2_02825 HuMAP2_03872 |
| PRKAG1 | HuMAP2_00168 HuMAP2_02825 HuMAP2_03872 HuMAP2_05529 |