hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02826
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ATPAF2 | ATP synthase mitochondrial F1 complex assembly factor 2 (ATP12 homolog) | UniProt NCBI |
| ALKBH8 | Alkylated DNA repair protein alkB homolog 8 (EC 1.14.11.-) (Probable alpha-ketoglutarate-dependent dioxygenase ABH8) (S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8) (tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8) (EC 2.1.1.229) | UniProt NCBI |
| MMP2 | 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] | UniProt NCBI |
| TIMP2 | Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2) | UniProt NCBI |
| FECH | Ferrochelatase, mitochondrial (EC 4.99.1.1) (Heme synthase) (Protoheme ferro-lyase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP129 | 0.00116821015313 | 0.4 | TIMP2 MMP2 | Matrix Metalloproteinases |
| REAC:R-HSA-1592389 | 0.00625202329777 | 0.4 | TIMP2 MMP2 | Activation of Matrix Metalloproteinases |
| CORUM:2798 | 0.0249780992026 | 0.2 | MMP2 | MMP-2-CLDN1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ALKBH8 | FECH | 0.292 | 0.493 | bioplex (FECH) bioplex_WMM |
| TIMP2 | FECH | 0.196 | 0.449 | bioplex (TIMP2) bioplex_WMM |
| MMP2 | TIMP2 | 0.042 | 0.27 | bioplex (MMP2) bioplex_WMM |
| FECH | ATPAF2 | 0.042 | 0.271 | bioplex (FECH) bioplex_WMM |
| ALKBH8 | ATPAF2 | 0.008 | 0.033 | bioplex_WMM WMM_only |
| MMP2 | FECH | 0.007 | 0.0 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02826 has an average edge precision of 0.253 which is ranked 5342 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ATPAF2 | HuMAP2_02826 HuMAP2_06512 |
| ALKBH8 | HuMAP2_02005 HuMAP2_02826 |
| MMP2 | HuMAP2_01361 HuMAP2_02826 HuMAP2_05564 HuMAP2_06424 |
| TIMP2 | HuMAP2_01361 HuMAP2_02005 HuMAP2_02826 HuMAP2_06424 |
| FECH | HuMAP2_02005 HuMAP2_02826 |