hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02828
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRUNE2 | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | UniProt NCBI |
| RPS6KA1 | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | UniProt NCBI |
| RPS6KA2 | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | UniProt NCBI |
| SRC | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | UniProt NCBI |
| ACBD7 | Acyl-CoA-binding domain-containing protein 7 | UniProt NCBI |
| FYN | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2332 | 1.36443750783e-05 | 0.5 | RPS6KA1 SRC FYN | Interleukin-11 Signaling Pathway |
| WP:WP304 | 4.12791181134e-05 | 0.5 | RPS6KA1 SRC FYN | Kit receptor signaling pathway |
| WP:WP2034 | 9.62694664711e-05 | 0.5 | RPS6KA1 SRC FYN | Leptin signaling pathway |
| WP:WP2037 | 9.62694664711e-05 | 0.5 | FYN RPS6KA2 SRC | Prolactin Signaling Pathway |
| REAC:R-HSA-438064 | 0.00036649373235 | 0.5 | RPS6KA1 RPS6KA2 SRC | Post NMDA receptor activation events |
| KEGG:05135 | 0.000377045038279 | 0.5 | RPS6KA1 RPS6KA2 SRC | Yersinia infection |
| REAC:R-HSA-444257 | 0.000465187760645 | 0.333333333333 | RPS6KA1 RPS6KA2 | RSK activation |
| REAC:R-HSA-199920 | 0.000465187760645 | 0.333333333333 | RPS6KA1 RPS6KA2 | CREB phosphorylation |
| REAC:R-HSA-442755 | 0.000560531240275 | 0.5 | RPS6KA1 RPS6KA2 SRC | Activation of NMDA receptors and postsynaptic events |
| WP:WP2380 | 0.000603242681284 | 0.5 | RPS6KA1 SRC FYN | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| REAC:R-HSA-166520 | 0.000713906652255 | 0.5 | RPS6KA1 RPS6KA2 SRC | Signaling by NTRKs |
| WP:WP437 | 0.000981982556245 | 0.5 | RPS6KA1 RPS6KA2 SRC | EGF/EGFR Signaling Pathway |
| WP:WP4357 | 0.00128637745568 | 0.333333333333 | SRC FYN | NRF2-ARE regulation |
| REAC:R-HSA-9006934 | 0.00129372739211 | 0.666666666667 | RPS6KA1 FYN RPS6KA2 SRC | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-881907 | 0.00265393377546 | 0.333333333333 | RPS6KA1 RPS6KA2 | Gastrin-CREB signalling pathway via PKC and MAPK |
| REAC:R-HSA-449147 | 0.00316317833645 | 0.666666666667 | RPS6KA1 FYN RPS6KA2 SRC | Signaling by Interleukins |
| REAC:R-HSA-422475 | 0.00323741737614 | 0.666666666667 | RPS6KA1 FYN RPS6KA2 SRC | Axon guidance |
| WP:WP2203 | 0.00455083797199 | 0.333333333333 | SRC FYN | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| WP:WP286 | 0.00477752328717 | 0.333333333333 | SRC FYN | IL-3 Signaling Pathway |
| REAC:R-HSA-112314 | 0.00509397763734 | 0.5 | RPS6KA1 RPS6KA2 SRC | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-198753 | 0.00510333351271 | 0.333333333333 | RPS6KA1 RPS6KA2 | ERK/MAPK targets |
| WP:WP4566 | 0.00573889859296 | 0.333333333333 | RPS6KA1 RPS6KA2 | Translation inhibitors in chronically activated PDGFRA cells |
| REAC:R-HSA-198725 | 0.00662414399653 | 0.333333333333 | RPS6KA1 RPS6KA2 | Nuclear Events (kinase and transcription factor activation) |
| REAC:R-HSA-442742 | 0.00717487015656 | 0.333333333333 | RPS6KA1 RPS6KA2 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-450282 | 0.0102563889288 | 0.333333333333 | RPS6KA1 RPS6KA2 | MAPK targets/ Nuclear events mediated by MAP kinases |
| REAC:R-HSA-1280215 | 0.0104210540447 | 0.666666666667 | RPS6KA1 FYN RPS6KA2 SRC | Cytokine Signaling in Immune system |
| REAC:R-HSA-112315 | 0.0110738408593 | 0.5 | RPS6KA1 RPS6KA2 SRC | Transmission across Chemical Synapses |
| WP:WP2032 | 0.0114940114472 | 0.333333333333 | RPS6KA1 SRC | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| KEGG:04720 | 0.0117137285677 | 0.333333333333 | RPS6KA1 RPS6KA2 | Long-term potentiation |
| KEGG:04520 | 0.0145139710642 | 0.333333333333 | SRC FYN | Adherens junction |
| WP:WP4298 | 0.0153070697985 | 0.333333333333 | SRC FYN | Viral Acute Myocarditis |
| REAC:R-HSA-1227986 | 0.0189534530409 | 0.333333333333 | SRC FYN | Signaling by ERBB2 |
| KEGG:04914 | 0.0200017533138 | 0.333333333333 | RPS6KA1 RPS6KA2 | Progesterone-mediated oocyte maturation |
| WP:WP477 | 0.0205911896387 | 0.333333333333 | RPS6KA1 RPS6KA2 | Cytoplasmic Ribosomal Proteins |
| WP:WP23 | 0.021066272601 | 0.333333333333 | RPS6KA1 FYN | B Cell Receptor Signaling Pathway |
| REAC:R-HSA-437239 | 0.0217814503669 | 0.333333333333 | RPS6KA1 RPS6KA2 | Recycling pathway of L1 |
| REAC:R-HSA-2219530 | 0.0217814503669 | 0.333333333333 | SRC FYN | Constitutive Signaling by Aberrant PI3K in Cancer |
| WP:WP185 | 0.0235215924424 | 0.333333333333 | SRC FYN | Integrin-mediated Cell Adhesion |
| WP:WP4321 | 0.0271822427146 | 0.333333333333 | RPS6KA1 RPS6KA2 | Thermogenesis |
| KEGG:04931 | 0.0316794238251 | 0.333333333333 | RPS6KA1 RPS6KA2 | Insulin resistance |
| REAC:R-HSA-1266738 | 0.0323042935377 | 0.666666666667 | RPS6KA1 FYN RPS6KA2 SRC | Developmental Biology |
| KEGG:04722 | 0.0348461971614 | 0.333333333333 | RPS6KA1 RPS6KA2 | Neurotrophin signaling pathway |
| KEGG:04114 | 0.0348461971614 | 0.333333333333 | RPS6KA1 RPS6KA2 | Oocyte meiosis |
| WP:WP4549 | 0.0358990321007 | 0.333333333333 | SRC FYN | Fragile X Syndrome |
| REAC:R-HSA-112316 | 0.0370544697669 | 0.5 | RPS6KA1 RPS6KA2 SRC | Neuronal System |
| KEGG:04611 | 0.0374860246019 | 0.333333333333 | SRC FYN | Platelet activation |
| WP:WP3915 | 0.0416969783243 | 0.333333333333 | RPS6KA1 RPS6KA2 | Angiopoietin Like Protein 8 Regulatory Pathway |
| REAC:R-HSA-450294 | 0.0428303754683 | 0.333333333333 | RPS6KA1 RPS6KA2 | MAP kinase activation |
| CORUM:2351 | 0.0499726005494 | 0.166666666667 | FYN | ITGB6-FYN-FN1 complex |
| CORUM:2073 | 0.0499726005494 | 0.166666666667 | SRC | TNFRSF11A-TRAF6-SRC complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SRC | FYN | 0.397 | 0.557 | bioplex (FYN) bioplex_WMM |
| RPS6KA1 | FYN | 0.052 | 0.3 | bioplex (FYN) bioplex_WMM |
| RPS6KA2 | FYN | 0.028 | 0.232 | bioplex (FYN) bioplex_WMM |
| FYN | PRUNE2 | 0.023 | 0.211 | bioplex (PRUNE2) bioplex_WMM |
| SRC | ACBD7 | 0.022 | 0.205 | bioplex (ACBD7) bioplex_WMM |
| SRC | PRUNE2 | 0.021 | 0.185 | bioplex (PRUNE2) bioplex_WMM |
| RPS6KA1 | RPS6KA2 | 0.014 | 0.14 | bioplex_WMM WMM_only |
| FYN | ACBD7 | 0.008 | 0.067 | bioplex (ACBD7) bioplex_WMM |
| RPS6KA2 | SRC | 0.007 | 0.002 | bioplex_WMM gupta_WMM WMM_only |
| RPS6KA1 | SRC | 0.007 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02828 has an average edge precision of 0.19 which is ranked 6302 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRUNE2 | HuMAP2_02828 HuMAP2_06036 |
| RPS6KA1 | HuMAP2_00566 HuMAP2_00821 HuMAP2_02828 HuMAP2_05297 HuMAP2_05462 |
| RPS6KA2 | HuMAP2_00566 HuMAP2_02828 HuMAP2_05297 HuMAP2_05462 |
| SRC | HuMAP2_00821 HuMAP2_02828 HuMAP2_06036 |
| ACBD7 | HuMAP2_02828 HuMAP2_06036 |
| FYN | HuMAP2_00821 HuMAP2_02828 HuMAP2_04012 HuMAP2_06036 |