hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02828

Confidence: Medium

Genename	Protein Name	Links
PRUNE2	Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1)	UniProt NCBI
RPS6KA1	Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)	UniProt NCBI
RPS6KA2	Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3)	UniProt NCBI
SRC	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)	UniProt NCBI
ACBD7	Acyl-CoA-binding domain-containing protein 7	UniProt NCBI
FYN	Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP2332	1.36443750783e-05	0.5	SRC RPS6KA1 FYN	Interleukin-11 Signaling Pathway
WP:WP304	4.12791181134e-05	0.5	SRC RPS6KA1 FYN	Kit receptor signaling pathway
WP:WP2034	9.62694664711e-05	0.5	SRC RPS6KA1 FYN	Leptin signaling pathway
WP:WP2037	9.62694664711e-05	0.5	RPS6KA2 FYN SRC	Prolactin Signaling Pathway
REAC:R-HSA-438064	0.00036649373235	0.5	RPS6KA2 RPS6KA1 SRC	Post NMDA receptor activation events
KEGG:05135	0.000377045038279	0.5	RPS6KA2 RPS6KA1 SRC	Yersinia infection
REAC:R-HSA-444257	0.000465187760645	0.333333333333	RPS6KA2 RPS6KA1	RSK activation
REAC:R-HSA-199920	0.000465187760645	0.333333333333	RPS6KA2 RPS6KA1	CREB phosphorylation
REAC:R-HSA-442755	0.000560531240275	0.5	RPS6KA2 RPS6KA1 SRC	Activation of NMDA receptors and postsynaptic events
WP:WP2380	0.000603242681284	0.5	SRC RPS6KA1 FYN	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
REAC:R-HSA-166520	0.000713906652255	0.5	RPS6KA2 RPS6KA1 SRC	Signaling by NTRKs
WP:WP437	0.000981982556245	0.5	RPS6KA2 RPS6KA1 SRC	EGF/EGFR Signaling Pathway
WP:WP4357	0.00128637745568	0.333333333333	SRC FYN	NRF2-ARE regulation
REAC:R-HSA-9006934	0.00129372739211	0.666666666667	RPS6KA2 FYN RPS6KA1 SRC	Signaling by Receptor Tyrosine Kinases
REAC:R-HSA-881907	0.00265393377546	0.333333333333	RPS6KA2 RPS6KA1	Gastrin-CREB signalling pathway via PKC and MAPK
REAC:R-HSA-449147	0.00316317833645	0.666666666667	RPS6KA2 FYN RPS6KA1 SRC	Signaling by Interleukins
REAC:R-HSA-422475	0.00323741737614	0.666666666667	RPS6KA2 FYN RPS6KA1 SRC	Axon guidance
WP:WP2203	0.00455083797199	0.333333333333	SRC FYN	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
WP:WP286	0.00477752328717	0.333333333333	SRC FYN	IL-3 Signaling Pathway
REAC:R-HSA-112314	0.00509397763734	0.5	RPS6KA2 RPS6KA1 SRC	Neurotransmitter receptors and postsynaptic signal transmission
REAC:R-HSA-198753	0.00510333351271	0.333333333333	RPS6KA2 RPS6KA1	ERK/MAPK targets
WP:WP4566	0.00573889859296	0.333333333333	RPS6KA2 RPS6KA1	Translation inhibitors in chronically activated PDGFRA cells
REAC:R-HSA-198725	0.00662414399653	0.333333333333	RPS6KA2 RPS6KA1	Nuclear Events (kinase and transcription factor activation)
REAC:R-HSA-442742	0.00717487015656	0.333333333333	RPS6KA2 RPS6KA1	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
REAC:R-HSA-450282	0.0102563889288	0.333333333333	RPS6KA2 RPS6KA1	MAPK targets/ Nuclear events mediated by MAP kinases
REAC:R-HSA-1280215	0.0104210540447	0.666666666667	RPS6KA2 FYN RPS6KA1 SRC	Cytokine Signaling in Immune system
REAC:R-HSA-112315	0.0110738408593	0.5	RPS6KA2 RPS6KA1 SRC	Transmission across Chemical Synapses
WP:WP2032	0.0114940114472	0.333333333333	SRC RPS6KA1	Human Thyroid Stimulating Hormone (TSH) signaling pathway
KEGG:04720	0.0117137285677	0.333333333333	RPS6KA2 RPS6KA1	Long-term potentiation
KEGG:04520	0.0145139710642	0.333333333333	SRC FYN	Adherens junction
WP:WP4298	0.0153070697985	0.333333333333	SRC FYN	Viral Acute Myocarditis
REAC:R-HSA-1227986	0.0189534530409	0.333333333333	SRC FYN	Signaling by ERBB2
KEGG:04914	0.0200017533138	0.333333333333	RPS6KA2 RPS6KA1	Progesterone-mediated oocyte maturation
WP:WP477	0.0205911896387	0.333333333333	RPS6KA2 RPS6KA1	Cytoplasmic Ribosomal Proteins
WP:WP23	0.021066272601	0.333333333333	RPS6KA1 FYN	B Cell Receptor Signaling Pathway
REAC:R-HSA-437239	0.0217814503669	0.333333333333	RPS6KA2 RPS6KA1	Recycling pathway of L1
REAC:R-HSA-2219530	0.0217814503669	0.333333333333	SRC FYN	Constitutive Signaling by Aberrant PI3K in Cancer
WP:WP185	0.0235215924424	0.333333333333	SRC FYN	Integrin-mediated Cell Adhesion
WP:WP4321	0.0271822427146	0.333333333333	RPS6KA2 RPS6KA1	Thermogenesis
KEGG:04931	0.0316794238251	0.333333333333	RPS6KA2 RPS6KA1	Insulin resistance
REAC:R-HSA-1266738	0.0323042935377	0.666666666667	RPS6KA2 FYN RPS6KA1 SRC	Developmental Biology
KEGG:04722	0.0348461971614	0.333333333333	RPS6KA2 RPS6KA1	Neurotrophin signaling pathway
KEGG:04114	0.0348461971614	0.333333333333	RPS6KA2 RPS6KA1	Oocyte meiosis
WP:WP4549	0.0358990321007	0.333333333333	SRC FYN	Fragile X Syndrome
REAC:R-HSA-112316	0.0370544697669	0.5	RPS6KA2 RPS6KA1 SRC	Neuronal System
KEGG:04611	0.0374860246019	0.333333333333	SRC FYN	Platelet activation
WP:WP3915	0.0416969783243	0.333333333333	RPS6KA2 RPS6KA1	Angiopoietin Like Protein 8 Regulatory Pathway
REAC:R-HSA-450294	0.0428303754683	0.333333333333	RPS6KA2 RPS6KA1	MAP kinase activation
CORUM:2351	0.0499726005494	0.166666666667	FYN	ITGB6-FYN-FN1 complex
CORUM:2073	0.0499726005494	0.166666666667	SRC	TNFRSF11A-TRAF6-SRC complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
SRC	FYN	0.397	0.557	bioplex (FYN) bioplex_WMM
RPS6KA1	FYN	0.052	0.3	bioplex (FYN) bioplex_WMM
RPS6KA2	FYN	0.028	0.232	bioplex (FYN) bioplex_WMM
FYN	PRUNE2	0.023	0.211	bioplex (PRUNE2) bioplex_WMM
SRC	ACBD7	0.022	0.205	bioplex (ACBD7) bioplex_WMM
SRC	PRUNE2	0.021	0.185	bioplex (PRUNE2) bioplex_WMM
RPS6KA1	RPS6KA2	0.014	0.14	bioplex_WMM WMM_only
FYN	ACBD7	0.008	0.067	bioplex (ACBD7) bioplex_WMM
RPS6KA2	SRC	0.007	0.002	bioplex_WMM gupta_WMM WMM_only
RPS6KA1	SRC	0.007	0.004	bioplex_WMM WMM_only

Images

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Complex HuMAP2_02828 has an average edge precision of 0.19 which is ranked 6302 out of all 6965 complexes.

Related Complexes

Genename	Complexes
PRUNE2	HuMAP2_02828 HuMAP2_06036
RPS6KA1	HuMAP2_00566 HuMAP2_00821 HuMAP2_02828 HuMAP2_05297 HuMAP2_05462
RPS6KA2	HuMAP2_00566 HuMAP2_02828 HuMAP2_05297 HuMAP2_05462
SRC	HuMAP2_00821 HuMAP2_02828 HuMAP2_06036
ACBD7	HuMAP2_02828 HuMAP2_06036
FYN	HuMAP2_00821 HuMAP2_02828 HuMAP2_04012 HuMAP2_06036

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02828