hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02830
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CD99L2 | CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99) | UniProt NCBI |
| TRIP12 | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | UniProt NCBI |
| CAPNS1 | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) | UniProt NCBI |
| CAPN1 | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | UniProt NCBI |
| CD109 | CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) | UniProt NCBI |
| CAPN8 | Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain) | UniProt NCBI |
| CAST | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | UniProt NCBI |
| LIX1L | LIX1-like protein | UniProt NCBI |
| RP9 | Retinitis pigmentosa 9 protein (Pim-1-associated protein) (PAP-1) | UniProt NCBI |
| CAPNS2 | Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8862803 | 1.27589564506e-07 | 0.4 | CAPNS2 CAPN1 CAST CAPNS1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 1.27589564506e-07 | 0.4 | CAPNS2 CAPN1 CAST CAPNS1 | Neurodegenerative Diseases |
| REAC:R-HSA-1474228 | 2.20763352289e-06 | 0.5 | CAPNS2 CAPN1 CAPNS1 CAST CAPN8 | Degradation of the extracellular matrix |
| GO:0004198 | 3.65237807149e-06 | 0.4 | CAPNS2 CAPN1 CAPN8 CAPNS1 | calcium-dependent cysteine-type endopeptidase activity |
| CORUM:6710 | 3.01890677263e-05 | 0.2 | CAPN1 CAPNS1 | Calpain 1 |
| REAC:R-HSA-1474244 | 8.7367804763e-05 | 0.5 | CAPNS2 CAPN1 CAPNS1 CAST CAPN8 | Extracellular matrix organization |
| GO:0004197 | 0.00917710278923 | 0.4 | CAPNS2 CAPN1 CAPN8 CAPNS1 | cysteine-type endopeptidase activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CAPNS2 | LIX1L | 1.0 | 0.949 | bioplex (CAPNS2) bioplex_WMM |
| CAPN1 | CAST | 1.0 | 0.949 | hein_WMM bioplex (CAPN1) bioplex_WMM youn_WMM hein (CAPN1) |
| CD99L2 | CAPN1 | 0.997 | 0.93 | bioplex (CAPN1) bioplex_WMM |
| CAPNS1 | CAPN1 | 0.992 | 0.912 | hein_WMM bioplex (CAPN1) bioplex_WMM hein (CAPN1) |
| CAST | CAPNS2 | 0.991 | 0.909 | bioplex (CAPNS2) bioplex_WMM |
| CAPN1 | CAPNS2 | 0.616 | 0.675 | bioplex (CAPN1,CAPNS2) bioplex_WMM |
| TRIP12 | CAPN1 | 0.527 | 0.634 | bioplex (CAPN1) bioplex_WMM youn_WMM |
| CAPN1 | CD109 | 0.351 | 0.537 | bioplex (CAPN1) bioplex_WMM fraction |
| CAST | CAPN8 | 0.131 | 0.403 | bioplex (CAPN8) bioplex_WMM |
| CAPN1 | RP9 | 0.044 | 0.274 | bioplex (CAPN1) bioplex_WMM |
| CAPN1 | CAPN8 | 0.022 | 0.205 | bioplex (CAPN8) bioplex_WMM |
| CAPNS1 | CAST | 0.013 | 0.149 | hein_WMM bioplex_WMM WMM_only |
| CAPNS1 | CAPNS2 | 0.013 | 0.154 | bioplex (CAPNS2) bioplex_WMM |
| CD99L2 | RP9 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| CAST | LIX1L | 0.009 | 0.098 | bioplex_WMM WMM_only |
| TRIP12 | RP9 | 0.008 | 0.084 | bioplex_WMM youn_WMM WMM_only |
| RP9 | CAST | 0.008 | 0.084 | bioplex_WMM youn_WMM WMM_only |
| CD99L2 | CAST | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CAPNS1 | LIX1L | 0.008 | 0.082 | bioplex_WMM WMM_only |
| CAPN1 | LIX1L | 0.008 | 0.08 | bioplex_WMM WMM_only |
| TRIP12 | CD99L2 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| RP9 | CAPNS2 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| CD99L2 | CAPNS2 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| CAPNS1 | RP9 | 0.008 | 0.043 | bioplex_WMM WMM_only |
| CAPNS1 | CD99L2 | 0.008 | 0.043 | bioplex_WMM WMM_only |
| RP9 | CD109 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| CD99L2 | CD109 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| TRIP12 | CAST | 0.008 | 0.013 | bioplex_WMM youn_WMM WMM_only |
| TRIP12 | CAPNS2 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| CAST | CD109 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| TRIP12 | CAPNS1 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| TRIP12 | CD109 | 0.007 | 0.0 | bioplex_WMM WMM_only treiber_WMM |
| CAPNS2 | CD109 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| CAPNS1 | CD109 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| CAPNS1 | CAPN8 | 0.007 | 0.003 | bioplex (CAPN8) bioplex_WMM |
Images
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Complex HuMAP2_02830 has an average edge precision of 0.247 which is ranked 5427 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CD99L2 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02449 HuMAP2_02830 |
| TRIP12 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02830 |
| CAPNS1 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02449 HuMAP2_02830 |
| CAPN1 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02449 HuMAP2_02830 HuMAP2_05795 |
| CD109 | HuMAP2_02830 HuMAP2_04553 HuMAP2_05795 |
| CAPN8 | HuMAP2_01890 HuMAP2_02830 |
| CAST | HuMAP2_01189 HuMAP2_01890 HuMAP2_02830 HuMAP2_04669 HuMAP2_05777 |
| LIX1L | HuMAP2_01317 HuMAP2_01890 HuMAP2_02830 HuMAP2_04669 |
| RP9 | HuMAP2_00660 HuMAP2_02830 |
| CAPNS2 | HuMAP2_01189 HuMAP2_01317 HuMAP2_01890 HuMAP2_02830 HuMAP2_04669 HuMAP2_05777 |