hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02831
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UBE2I | SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) | UniProt NCBI |
| KPNA4 | Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4) | UniProt NCBI |
| RCC1 | Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) | UniProt NCBI |
| KPNB1 | Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) | UniProt NCBI |
| KPNA3 | Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-168276 | 2.10552596086e-05 | 0.6 | KPNA3 KPNA4 KPNB1 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-168253 | 2.28576897279e-05 | 0.6 | KPNA3 KPNA4 KPNB1 | Host Interactions with Influenza Factors |
| REAC:R-HSA-1169408 | 0.00012942105654 | 0.6 | KPNA3 KPNA4 KPNB1 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 0.000175005907139 | 0.6 | KPNA3 KPNA4 KPNB1 | Antiviral mechanism by IFN-stimulated genes |
| GO:0005635 | 0.000201815974304 | 1.0 | KPNB1 KPNA3 UBE2I KPNA4 RCC1 | nuclear envelope |
| REAC:R-HSA-5663205 | 0.000241108816086 | 0.8 | KPNB1 KPNA3 KPNA4 RCC1 | Infectious disease |
| GO:0019054 | 0.000330213415772 | 0.6 | KPNA3 KPNA4 KPNB1 | modulation by virus of host cellular process |
| GO:0006607 | 0.00103355958129 | 0.6 | KPNA3 KPNA4 KPNB1 | NLS-bearing protein import into nucleus |
| GO:0044068 | 0.00120569794977 | 0.6 | KPNA3 KPNA4 KPNB1 | modulation by symbiont of host cellular process |
| GO:0008139 | 0.00139593056214 | 0.6 | KPNA3 KPNA4 KPNB1 | nuclear localization sequence binding |
| REAC:R-HSA-168254 | 0.00141854667829 | 0.6 | KPNA3 KPNA4 KPNB1 | Influenza Infection |
| GO:0019048 | 0.00208420080219 | 0.6 | KPNA3 KPNA4 KPNB1 | modulation by virus of host morphology or physiology |
| REAC:R-HSA-913531 | 0.00230616063943 | 0.6 | KPNA3 KPNA4 KPNB1 | Interferon Signaling |
| REAC:R-HSA-180746 | 0.00584945327803 | 0.4 | RCC1 KPNB1 | Nuclear import of Rev protein |
| GO:0044003 | 0.005924931483 | 0.6 | KPNA3 KPNA4 KPNB1 | modification by symbiont of host morphology or physiology |
| REAC:R-HSA-177243 | 0.00709716303977 | 0.4 | RCC1 KPNB1 | Interactions of Rev with host cellular proteins |
| GO:0005048 | 0.00826983957236 | 0.6 | KPNA3 KPNA4 KPNB1 | signal sequence binding |
| REAC:R-HSA-1643685 | 0.0116415059931 | 0.8 | KPNB1 KPNA3 KPNA4 RCC1 | Disease |
| GO:0031975 | 0.0253087624128 | 1.0 | KPNB1 KPNA3 UBE2I KPNA4 RCC1 | envelope |
| GO:0031967 | 0.0253087624128 | 1.0 | KPNB1 KPNA3 UBE2I KPNA4 RCC1 | organelle envelope |
| MIRNA:hsa-miR-566 | 0.0466750398091 | 0.4 | KPNB1 UBE2I | hsa-miR-566 |
| KEGG:03013 | 0.0489206453689 | 0.4 | KPNB1 UBE2I | RNA transport |
| CORUM:6142 | 0.0499494897235 | 0.2 | KPNB1 | KPNA2-KPNB1 complex |
| CORUM:6143 | 0.0499494897235 | 0.2 | KPNB1 | KPNB1-RAN complex |
| CORUM:7543 | 0.0499494897235 | 0.2 | KPNB1 | KPNB1-SMN-SPN complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| KPNA4 | KPNA3 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| RCC1 | UBE2I | 0.995 | 0.924 | hein_WMM bioplex (RCC1,UBE2I) bioplex_WMM youn_WMM hein (RCC1,UBE2I) gupta_WMM |
| KPNA4 | RCC1 | 0.977 | 0.893 | hein_WMM bioplex (RCC1) bioplex_WMM youn_WMM hein (RCC1) gupta_WMM |
| RCC1 | KPNA3 | 0.928 | 0.844 | hein_WMM bioplex (RCC1) bioplex_WMM youn_WMM hein (RCC1) gupta_WMM |
| KPNA3 | KPNB1 | 0.757 | 0.747 | hein_WMM bioplex_WMM hein (KPNB1) fraction treiber_WMM |
| RCC1 | KPNB1 | 0.613 | 0.673 | hein_WMM bioplex (RCC1) bioplex_WMM hein (KPNB1,RCC1) treiber_WMM |
| KPNA4 | KPNB1 | 0.084 | 0.349 | hein_WMM bioplex_WMM hein (KPNB1) fraction |
| KPNA4 | UBE2I | 0.018 | 0.178 | hein_WMM bioplex (UBE2I) bioplex_WMM youn_WMM gupta_WMM |
| KPNA3 | UBE2I | 0.015 | 0.148 | hein_WMM bioplex (UBE2I) bioplex_WMM youn_WMM gupta_WMM |
| KPNB1 | UBE2I | 0.004 | 0.009 | hein_WMM bioplex (UBE2I) bioplex_WMM hein (KPNB1,UBE2I) |
Images
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Complex HuMAP2_02831 has an average edge precision of 0.571 which is ranked 2071 out of all 6965 complexes.
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