hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02833
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAPK8 | Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) | UniProt NCBI |
| MAPK9 | Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) | UniProt NCBI |
| DUSP8 | Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5) | UniProt NCBI |
| WDR62 | WD repeat-containing protein 62 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3874 | 0.000176203894069 | 0.5 | MAPK8 MAPK9 | Canonical and Non-Canonical TGF-B signaling |
| WP:WP382 | 0.000385360586168 | 0.75 | MAPK8 DUSP8 MAPK9 | MAPK Signaling Pathway |
| WP:WP3869 | 0.000424263272643 | 0.5 | MAPK8 MAPK9 | Cannabinoid receptor signaling |
| REAC:R-HSA-450341 | 0.000452175281072 | 0.5 | MAPK8 MAPK9 | Activation of the AP-1 family of transcription factors |
| WP:WP2643 | 0.000633595541779 | 0.5 | MAPK8 MAPK9 | Nanoparticle-mediated activation of receptor signaling |
| KEGG:04010 | 0.000734165415649 | 0.75 | MAPK8 DUSP8 MAPK9 | MAPK signaling pathway |
| KEGG:04215 | 0.000869408386689 | 0.5 | MAPK8 MAPK9 | Apoptosis - multiple species |
| WP:WP4150 | 0.000939830639711 | 0.5 | MAPK8 MAPK9 | Wnt Signaling in Kidney Disease |
| WP:WP2036 | 0.00130601363574 | 0.5 | MAPK8 MAPK9 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| WP:WP2203 | 0.00137286558226 | 0.5 | MAPK8 MAPK9 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| WP:WP4534 | 0.00137286558226 | 0.5 | MAPK8 MAPK9 | Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms |
| WP:WP4566 | 0.00173204740358 | 0.5 | MAPK8 MAPK9 | Translation inhibitors in chronically activated PDGFRA cells |
| KEGG:04930 | 0.00188834163584 | 0.5 | MAPK8 MAPK9 | Type II diabetes mellitus |
| WP:WP363 | 0.00196747799108 | 0.5 | MAPK8 MAPK9 | Wnt Signaling Pathway |
| WP:WP2637 | 0.00196747799108 | 0.5 | MAPK8 MAPK9 | Structural Pathway of Interleukin 1 (IL-1) |
| WP:WP195 | 0.00213272485195 | 0.5 | MAPK8 MAPK9 | IL-1 signaling pathway |
| WP:WP2018 | 0.00221783487587 | 0.5 | MAPK8 MAPK9 | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| REAC:R-HSA-450321 | 0.00231867248578 | 0.5 | MAPK8 MAPK9 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| WP:WP3865 | 0.0023930258657 | 0.5 | MAPK8 MAPK9 | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| WP:WP4538 | 0.00257484178538 | 0.5 | MAPK8 MAPK9 | Regulatory circuits of the STAT3 signaling pathway |
| KEGG:04664 | 0.00296133374321 | 0.5 | MAPK8 MAPK9 | Fc epsilon RI signaling pathway |
| REAC:R-HSA-2871796 | 0.00326103241616 | 0.5 | MAPK8 MAPK9 | FCERI mediated MAPK activation |
| WP:WP4341 | 0.00326331699224 | 0.5 | MAPK8 MAPK9 | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
| WP:WP2374 | 0.00336828295894 | 0.5 | MAPK8 MAPK9 | Oncostatin M Signaling Pathway |
| WP:WP2324 | 0.0034749006715 | 0.5 | MAPK8 MAPK9 | AGE/RAGE pathway |
| WP:WP3303 | 0.0034749006715 | 0.5 | MAPK8 MAPK9 | RAC1/PAK1/p38/MMP2 Pathway |
| KEGG:05133 | 0.00352808727693 | 0.5 | MAPK8 MAPK9 | Pertussis |
| KEGG:05120 | 0.00364735612249 | 0.5 | MAPK8 MAPK9 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:04137 | 0.00376859643257 | 0.5 | MAPK8 MAPK9 | Mitophagy - animal |
| KEGG:04917 | 0.00376859643257 | 0.5 | MAPK8 MAPK9 | Prolactin signaling pathway |
| KEGG:04920 | 0.00401698930658 | 0.5 | MAPK8 MAPK9 | Adipocytokine signaling pathway |
| KEGG:04622 | 0.00401698930658 | 0.5 | MAPK8 MAPK9 | RIG-I-like receptor signaling pathway |
| KEGG:05131 | 0.00401698930658 | 0.5 | MAPK8 MAPK9 | Shigellosis |
| WP:WP4216 | 0.0041492685023 | 0.5 | MAPK8 MAPK9 | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:05132 | 0.00440435122993 | 0.5 | MAPK8 MAPK9 | Salmonella infection |
| WP:WP2037 | 0.00450871467598 | 0.5 | MAPK8 MAPK9 | Prolactin Signaling Pathway |
| REAC:R-HSA-450282 | 0.00466369436644 | 0.5 | MAPK8 MAPK9 | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:04657 | 0.00480942745524 | 0.5 | MAPK8 MAPK9 | IL-17 signaling pathway |
| WP:WP69 | 0.00488298622434 | 0.5 | MAPK8 MAPK9 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| KEGG:05212 | 0.00494838688052 | 0.5 | MAPK8 MAPK9 | Pancreatic cancer |
| KEGG:04658 | 0.00494838688052 | 0.5 | MAPK8 MAPK9 | Th1 and Th2 cell differentiation |
| WP:WP4263 | 0.00567595707464 | 0.5 | MAPK8 MAPK9 | Pancreatic adenocarcinoma pathway |
| WP:WP2355 | 0.00581387281279 | 0.5 | MAPK8 MAPK9 | Corticotropin-releasing hormone signaling pathway |
| WP:WP673 | 0.00595343133727 | 0.5 | MAPK8 MAPK9 | ErbB Signaling Pathway |
| KEGG:04012 | 0.00613079763587 | 0.5 | MAPK8 MAPK9 | ErbB signaling pathway |
| WP:WP231 | 0.0063819591539 | 0.5 | MAPK8 MAPK9 | TNF alpha Signaling Pathway |
| WP:WP23 | 0.0063819591539 | 0.5 | MAPK8 MAPK9 | B Cell Receptor Signaling Pathway |
| WP:WP75 | 0.0063819591539 | 0.5 | MAPK8 MAPK9 | Toll-like Receptor Signaling Pathway |
| KEGG:04912 | 0.00644602944709 | 0.5 | MAPK8 MAPK9 | GnRH signaling pathway |
| KEGG:04914 | 0.00644602944709 | 0.5 | MAPK8 MAPK9 | Progesterone-mediated oocyte maturation |
| KEGG:04750 | 0.00644602944709 | 0.5 | MAPK8 MAPK9 | Inflammatory mediator regulation of TRP channels |
| KEGG:05210 | 0.00660658678392 | 0.5 | MAPK8 MAPK9 | Colorectal cancer |
| KEGG:04659 | 0.00726841321698 | 0.5 | MAPK8 MAPK9 | Th17 cell differentiation |
| KEGG:04620 | 0.00726841321698 | 0.5 | MAPK8 MAPK9 | Toll-like receptor signaling pathway |
| KEGG:04625 | 0.00761107721317 | 0.5 | MAPK8 MAPK9 | C-type lectin receptor signaling pathway |
| KEGG:05142 | 0.00761107721317 | 0.5 | MAPK8 MAPK9 | Chagas disease (American trypanosomiasis) |
| KEGG:05231 | 0.00778534503861 | 0.5 | MAPK8 MAPK9 | Choline metabolism in cancer |
| KEGG:04660 | 0.00796156937098 | 0.5 | MAPK8 MAPK9 | T cell receptor signaling pathway |
| KEGG:01522 | 0.00796156937098 | 0.5 | MAPK8 MAPK9 | Endocrine resistance |
| GO:0016909 | 0.00811409485621 | 0.5 | MAPK8 MAPK9 | SAP kinase activity |
| GO:0004705 | 0.00811409485621 | 0.5 | MAPK8 MAPK9 | JUN kinase activity |
| KEGG:04933 | 0.00813974967686 | 0.5 | MAPK8 MAPK9 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:04668 | 0.00850197607578 | 0.5 | MAPK8 MAPK9 | TNF signaling pathway |
| KEGG:05145 | 0.00868602110226 | 0.5 | MAPK8 MAPK9 | Toxoplasmosis |
| WP:WP710 | 0.00891657780243 | 0.5 | MAPK8 MAPK9 | DNA Damage Response (only ATM dependent) |
| WP:WP428 | 0.00943843856088 | 0.5 | MAPK8 MAPK9 | Wnt Signaling |
| KEGG:04931 | 0.0102286747914 | 0.5 | MAPK8 MAPK9 | Insulin resistance |
| KEGG:04380 | 0.0104302851929 | 0.5 | MAPK8 MAPK9 | Osteoclast differentiation |
| KEGG:04722 | 0.0112562119133 | 0.5 | MAPK8 MAPK9 | Neurotrophin signaling pathway |
| WP:WP1449 | 0.0114775392713 | 0.5 | MAPK8 MAPK9 | Regulation of toll-like receptor signaling pathway |
| KEGG:04071 | 0.0116808588864 | 0.5 | MAPK8 MAPK9 | Sphingolipid signaling pathway |
| KEGG:05135 | 0.0123324218825 | 0.5 | MAPK8 MAPK9 | Yersinia infection |
| WP:WP366 | 0.012672821387 | 0.5 | MAPK8 MAPK9 | TGF-beta Signaling Pathway |
| WP:WP3915 | 0.012672821387 | 0.5 | MAPK8 MAPK9 | Angiopoietin Like Protein 8 Regulatory Pathway |
| KEGG:04068 | 0.012776519361 | 0.5 | MAPK8 MAPK9 | FoxO signaling pathway |
| KEGG:04926 | 0.0141554312811 | 0.5 | MAPK8 MAPK9 | Relaxin signaling pathway |
| KEGG:04728 | 0.014392043024 | 0.5 | MAPK8 MAPK9 | Dopaminergic synapse |
| WP:WP2380 | 0.0152387809455 | 0.5 | MAPK8 MAPK9 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| KEGG:04210 | 0.0153578793248 | 0.5 | MAPK8 MAPK9 | Apoptosis |
| KEGG:04910 | 0.0153578793248 | 0.5 | MAPK8 MAPK9 | Insulin signaling pathway |
| KEGG:05418 | 0.0153578793248 | 0.5 | MAPK8 MAPK9 | Fluid shear stress and atherosclerosis |
| WP:WP4396 | 0.0154631487697 | 0.5 | MAPK8 MAPK9 | Nonalcoholic fatty liver disease |
| KEGG:05162 | 0.0161026004622 | 0.5 | MAPK8 MAPK9 | Measles |
| KEGG:04723 | 0.0171226599156 | 0.5 | MAPK8 MAPK9 | Retrograde endocannabinoid signaling |
| WP:WP4666 | 0.0173163427152 | 0.5 | MAPK8 MAPK9 | Hepatitis B infection |
| KEGG:04140 | 0.0173825101547 | 0.5 | MAPK8 MAPK9 | Autophagy - animal |
| KEGG:04932 | 0.0173825101547 | 0.5 | MAPK8 MAPK9 | Non-alcoholic fatty liver disease (NAFLD) |
| WP:WP481 | 0.0195247658454 | 0.5 | MAPK8 MAPK9 | Insulin Signaling |
| REAC:R-HSA-450294 | 0.0195313767937 | 0.5 | MAPK8 MAPK9 | MAP kinase activation |
| WP:WP4223 | 0.0197782099748 | 0.5 | MAPK8 MAPK9 | Ras Signaling |
| KEGG:04530 | 0.0206513420529 | 0.5 | MAPK8 MAPK9 | Tight junction |
| WP:WP437 | 0.0210695886397 | 0.5 | MAPK8 MAPK9 | EGF/EGFR Signaling Pathway |
| KEGG:04310 | 0.0212231461989 | 0.5 | MAPK8 MAPK9 | Wnt signaling pathway |
| WP:WP3594 | 0.021597405556 | 0.5 | MAPK8 MAPK9 | Circadian rhythm related genes |
| KEGG:05152 | 0.0220952935316 | 0.5 | MAPK8 MAPK9 | Tuberculosis |
| KEGG:04217 | 0.0226863463099 | 0.5 | MAPK8 MAPK9 | Necroptosis |
| REAC:R-HSA-448424 | 0.0234490216385 | 0.5 | MAPK8 MAPK9 | Interleukin-17 signaling |
| KEGG:05161 | 0.0235873467107 | 0.5 | MAPK8 MAPK9 | Hepatitis B |
| KEGG:04141 | 0.0241976216174 | 0.5 | MAPK8 MAPK9 | Protein processing in endoplasmic reticulum |
| KEGG:04621 | 0.0245056398731 | 0.5 | MAPK8 MAPK9 | NOD-like receptor signaling pathway |
| KEGG:05167 | 0.0267154932054 | 0.5 | MAPK8 MAPK9 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04024 | 0.0283514541231 | 0.5 | MAPK8 MAPK9 | cAMP signaling pathway |
| REAC:R-HSA-449147 | 0.0289233648573 | 0.75 | MAPK8 DUSP8 MAPK9 | Signaling by Interleukins |
| WP:WP306 | 0.0290430519819 | 0.5 | MAPK8 MAPK9 | Focal Adhesion |
| KEGG:05130 | 0.0307221505972 | 0.5 | MAPK8 MAPK9 | Pathogenic Escherichia coli infection |
| KEGG:05169 | 0.0328286642151 | 0.5 | MAPK8 MAPK9 | Epstein-Barr virus infection |
| REAC:R-HSA-168142 | 0.0331557329305 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-168176 | 0.0331557329305 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975871 | 0.0331557329305 | 0.5 | MAPK8 MAPK9 | MyD88 cascade initiated on plasma membrane |
| KEGG:04014 | 0.0331864260111 | 0.5 | MAPK8 MAPK9 | Ras signaling pathway |
| REAC:R-HSA-975138 | 0.0347967852364 | 0.5 | MAPK8 MAPK9 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| KEGG:04510 | 0.0350038155474 | 0.5 | MAPK8 MAPK9 | Focal adhesion |
| REAC:R-HSA-975155 | 0.0356320611636 | 0.5 | MAPK8 MAPK9 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 0.0356320611636 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| KEGG:05166 | 0.0380105899241 | 0.5 | MAPK8 MAPK9 | Human T-cell leukemia virus 1 infection |
| KEGG:05170 | 0.0387812861874 | 0.5 | MAPK8 MAPK9 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-168188 | 0.0390714342086 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.0390714342086 | 0.5 | MAPK8 MAPK9 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168138 | 0.0390714342086 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor 9 (TLR9) Cascade |
| WP:WP3888 | 0.0393304030404 | 0.5 | MAPK8 MAPK9 | VEGFA-VEGFR2 Signaling Pathway |
| REAC:R-HSA-168164 | 0.0399558314157 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-168179 | 0.041754071825 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.041754071825 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-937061 | 0.042667909674 | 0.5 | MAPK8 MAPK9 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.042667909674 | 0.5 | MAPK8 MAPK9 | MyD88-independent TLR4 cascade |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAPK8 | MAPK9 | 1.0 | 0.949 | bioplex (MAPK8) bioplex_WMM |
| MAPK8 | WDR62 | 0.991 | 0.909 | bioplex (MAPK8) bioplex_WMM |
| MAPK8 | DUSP8 | 0.031 | 0.239 | bioplex (MAPK8) bioplex_WMM |
| DUSP8 | MAPK9 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| DUSP8 | WDR62 | 0.008 | 0.023 | bioplex_WMM WMM_only |
| WDR62 | MAPK9 | 0.007 | 0.007 | bioplex_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_02833 has an average edge precision of 0.369 which is ranked 3653 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAPK8 | HuMAP2_02833 HuMAP2_06007 |
| MAPK9 | HuMAP2_02833 HuMAP2_06007 |
| DUSP8 | HuMAP2_02833 |
| WDR62 | HuMAP2_02833 HuMAP2_05878 HuMAP2_06007 |