hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02836
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WRN | Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2) | UniProt NCBI |
| XRCC5 | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | UniProt NCBI |
| XRCC6 | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:4082 | 2.25356268047e-10 | 1.0 | WRN XRCC5 XRCC6 | XRCC6-XRCC5-WRN complex |
| CORUM:5235 | 9.0142507219e-10 | 1.0 | WRN XRCC5 XRCC6 | WRN-Ku70-Ku80-PARP1 complex |
| CORUM:328 | 3.35600554376e-06 | 0.666666666667 | XRCC5 XRCC6 | Ku antigen complex |
| CORUM:4081 | 3.35600554376e-06 | 0.666666666667 | XRCC5 XRCC6 | Ku antigen complex |
| CORUM:322 | 1.00675659188e-05 | 0.666666666667 | XRCC5 XRCC6 | DNA-PK-Ku complex |
| CORUM:1092 | 1.00675659188e-05 | 0.666666666667 | XRCC5 XRCC6 | PCNA-KU antigen complex |
| CORUM:357 | 1.00675659188e-05 | 0.666666666667 | XRCC5 XRCC6 | DNA-PK-Ku complex |
| CORUM:6310 | 1.00675659188e-05 | 0.666666666667 | XRCC5 XRCC6 | DEAF1- complex |
| CORUM:356 | 1.00675659188e-05 | 0.666666666667 | XRCC5 XRCC6 | DNA-PK-Ku complex |
| CORUM:355 | 1.00675659188e-05 | 0.666666666667 | XRCC5 XRCC6 | DNA-PK-Ku complex |
| CORUM:95 | 1.00675659188e-05 | 0.666666666667 | XRCC5 XRCC6 | Ku antigen-NARG1 complex |
| CORUM:5182 | 1.00675659188e-05 | 0.666666666667 | XRCC5 XRCC6 | DNA-PK-Ku complex |
| CORUM:2918 | 1.00675659188e-05 | 0.666666666667 | XRCC5 XRCC6 | Ku antigen-YY1-alphaMyHC promoter complex |
| CORUM:1220 | 1.00675659188e-05 | 0.666666666667 | XRCC5 XRCC6 | TRF2-Ku complex |
| CORUM:1571 | 2.01342304124e-05 | 0.666666666667 | XRCC5 XRCC6 | Vigilin-DNA-PK-Ku antigen complex |
| CORUM:5176 | 2.01342304124e-05 | 0.666666666667 | XRCC5 XRCC6 | MGC1-DNA-PKcs-Ku complex |
| CORUM:7217 | 2.01342304124e-05 | 0.666666666667 | XRCC5 XRCC6 | Dysbindin 1-A-DNA-PK-complex |
| WP:WP438 | 2.01386649763e-05 | 0.666666666667 | XRCC5 XRCC6 | Non-homologous end joining |
| CORUM:5179 | 3.35555483123e-05 | 0.666666666667 | XRCC5 XRCC6 | NCOA6-DNA-PK-Ku-PARP1 complex |
| CORUM:5231 | 3.35555483123e-05 | 0.666666666667 | XRCC5 XRCC6 | 53BP1-containing complex |
| KEGG:03450 | 3.49141490189e-05 | 0.666666666667 | XRCC5 XRCC6 | Non-homologous end-joining |
| CORUM:3102 | 5.03310689057e-05 | 0.666666666667 | XRCC5 XRCC6 | DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex |
| CORUM:5251 | 5.03310689057e-05 | 0.666666666667 | XRCC5 XRCC6 | Ku-ORC complex |
| GO:0071480 | 6.17566316957e-05 | 1.0 | WRN XRCC5 XRCC6 | cellular response to gamma radiation |
| CORUM:1189 | 7.04603414803e-05 | 0.666666666667 | XRCC5 XRCC6 | DNA double-strand break end-joining complex |
| CORUM:1193 | 7.04603414803e-05 | 0.666666666667 | XRCC5 XRCC6 | Rap1 complex |
| CORUM:2766 | 7.04603414803e-05 | 0.666666666667 | XRCC5 XRCC6 | TERF2-RAP1 complex |
| CORUM:5183 | 9.39429153233e-05 | 0.666666666667 | XRCC5 XRCC6 | DNA-PK-Ku-eIF2-NF90-NF45 complex |
| CORUM:7285 | 0.000120778339722 | 0.666666666667 | XRCC5 XRCC6 | HEXIM1-DNA-PK-paraspeckle components-ribonucleoprotein complex |
| REAC:R-HSA-164843 | 0.000140571869389 | 0.666666666667 | XRCC5 XRCC6 | 2-LTR circle formation |
| GO:0010332 | 0.000183816797871 | 1.0 | WRN XRCC5 XRCC6 | response to gamma radiation |
| REAC:R-HSA-162592 | 0.000240958766872 | 0.666666666667 | XRCC5 XRCC6 | Integration of provirus |
| REAC:R-HSA-5693532 | 0.000324502864875 | 1.0 | WRN XRCC5 XRCC6 | DNA Double-Strand Break Repair |
| REAC:R-HSA-3270619 | 0.000521983812065 | 0.666666666667 | XRCC5 XRCC6 | IRF3-mediated induction of type I IFN |
| REAC:R-HSA-162594 | 0.00060895383853 | 0.666666666667 | XRCC5 XRCC6 | Early Phase of HIV Life Cycle |
| GO:0042162 | 0.000648444632805 | 1.0 | WRN XRCC5 XRCC6 | telomeric DNA binding |
| REAC:R-HSA-1834941 | 0.000802944115303 | 0.666666666667 | XRCC5 XRCC6 | STING mediated induction of host immune responses |
| GO:0071479 | 0.00137862598403 | 1.0 | WRN XRCC5 XRCC6 | cellular response to ionizing radiation |
| REAC:R-HSA-73894 | 0.00245537461814 | 1.0 | WRN XRCC5 XRCC6 | DNA Repair |
| GO:0003678 | 0.00265735153444 | 1.0 | WRN XRCC5 XRCC6 | DNA helicase activity |
| WP:WP4016 | 0.0028706736774 | 0.666666666667 | WRN XRCC5 | DNA IR-damage and cellular response via ATR |
| GO:0043564 | 0.00405722906526 | 0.666666666667 | XRCC5 XRCC6 | Ku70:Ku80 complex |
| GO:0010212 | 0.00929437307021 | 1.0 | WRN XRCC5 XRCC6 | response to ionizing radiation |
| GO:0004386 | 0.0106693663112 | 1.0 | WRN XRCC5 XRCC6 | helicase activity |
| GO:0008094 | 0.011404996777 | 1.0 | WRN XRCC5 XRCC6 | DNA-dependent ATPase activity |
| REAC:R-HSA-1834949 | 0.0130404028432 | 0.666666666667 | XRCC5 XRCC6 | Cytosolic sensors of pathogen-associated DNA |
| GO:0051575 | 0.0135228859698 | 0.666666666667 | XRCC5 XRCC6 | 5'-deoxyribose-5-phosphate lyase activity |
| REAC:R-HSA-5693571 | 0.015660289467 | 0.666666666667 | XRCC5 XRCC6 | Nonhomologous End-Joining (NHEJ) |
| GO:0071481 | 0.020283420769 | 0.666666666667 | XRCC5 XRCC6 | cellular response to X-ray |
| GO:0071478 | 0.0310032822085 | 1.0 | WRN XRCC5 XRCC6 | cellular response to radiation |
| GO:0075713 | 0.0378589948753 | 0.666666666667 | XRCC5 XRCC6 | establishment of integrated proviral latency |
| GO:0000781 | 0.0397775372938 | 1.0 | WRN XRCC5 XRCC6 | chromosome, telomeric region |
| GO:0019043 | 0.0486736709081 | 0.666666666667 | XRCC5 XRCC6 | establishment of viral latency |
| GO:0070419 | 0.0486736709081 | 0.666666666667 | XRCC5 XRCC6 | nonhomologous end joining complex |
| GO:0003691 | 0.0486736709081 | 0.666666666667 | XRCC5 XRCC6 | double-stranded telomeric DNA binding |
| CORUM:1217 | 0.0499776345577 | 0.333333333333 | WRN | WRN-TRF2 complex |
| CORUM:7282 | 0.0499776345577 | 0.333333333333 | WRN | FEN1-WRN complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC5 | XRCC6 | 1.0 | 0.949 | hein_WMM bioplex (XRCC6) bioplex_WMM Guru boldt youn_WMM hein (XRCC5,XRCC6) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| XRCC6 | WRN | 0.999 | 0.949 | hein_WMM bioplex (XRCC6) bioplex_WMM boldt youn_WMM hein (XRCC6) boldt_WMM |
| XRCC5 | WRN | 0.006 | 0.009 | hein_WMM bioplex_WMM boldt youn_WMM hein (XRCC5) boldt_WMM |
Images
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Complex HuMAP2_02836 has an average edge precision of 0.636 which is ranked 1742 out of all 6965 complexes.
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