hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02851
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VPS13B | Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1) | UniProt NCBI |
| STUB1 | E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1) | UniProt NCBI |
| DNAJC7 | DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2) | UniProt NCBI |
| URGCP | Up-regulator of cell proliferation (HBV X protein up-regulated gene 4 protein) (HBxAg up-regulated gene 4 protein) | UniProt NCBI |
| KIAA0100 | Protein KIAA0100 (Antigen MLAA-22) (Breast cancer-overexpressed gene 1 protein) | UniProt NCBI |
| BAG5 | BAG family molecular chaperone regulator 5 (BAG-5) (Bcl-2-associated athanogene 5) | UniProt NCBI |
| BAG2 | BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2) | UniProt NCBI |
| EML5 | Echinoderm microtubule-associated protein-like 5 (EMAP-5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3371453 | 0.000775544821205 | 0.375 | BAG5 BAG2 DNAJC7 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-3371556 | 0.00174484118312 | 0.375 | BAG5 BAG2 DNAJC7 | Cellular response to heat stress |
| GO:0034605 | 0.00739084325394 | 0.5 | STUB1 BAG2 DNAJC7 BAG5 | cellular response to heat |
| GO:0009408 | 0.0123557309189 | 0.5 | STUB1 BAG2 DNAJC7 BAG5 | response to heat |
| GO:0009266 | 0.025421718431 | 0.5 | STUB1 BAG2 DNAJC7 BAG5 | response to temperature stimulus |
| CORUM:432 | 0.0497224828424 | 0.125 | STUB1 | N-NOS-CHIP-HSP70-1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DNAJC7 | STUB1 | 0.638 | 0.685 | hein_WMM bioplex_WMM boldt youn_WMM hein (DNAJC7) gupta_WMM boldt_WMM |
| DNAJC7 | BAG2 | 0.6 | 0.671 | hein_WMM bioplex (DNAJC7) bioplex_WMM boldt hein (BAG2,DNAJC7) gupta_WMM boldt_WMM |
| DNAJC7 | KIAA0100 | 0.25 | 0.474 | hein_WMM bioplex (DNAJC7) bioplex_WMM youn_WMM hein (DNAJC7) |
| DNAJC7 | VPS13B | 0.218 | 0.466 | hein_WMM bioplex (DNAJC7) bioplex_WMM hein (DNAJC7) |
| BAG2 | STUB1 | 0.194 | 0.447 | hein_WMM bioplex_WMM boldt hein (BAG2) gupta_WMM boldt_WMM |
| DNAJC7 | EML5 | 0.092 | 0.355 | bioplex (DNAJC7) bioplex_WMM |
| BAG5 | STUB1 | 0.025 | 0.214 | bioplex (BAG5) bioplex_WMM boldt gupta_WMM boldt_WMM |
| DNAJC7 | URGCP | 0.024 | 0.211 | bioplex (DNAJC7) bioplex_WMM |
| DNAJC7 | BAG5 | 0.021 | 0.188 | bioplex (BAG5,DNAJC7) bioplex_WMM boldt gupta_WMM boldt_WMM |
| BAG2 | BAG5 | 0.01 | 0.098 | bioplex (BAG5) bioplex_WMM boldt gupta_WMM boldt_WMM |
| KIAA0100 | VPS13B | 0.009 | 0.108 | hein_WMM bioplex_WMM WMM_only |
| EML5 | URGCP | 0.008 | 0.087 | bioplex_WMM WMM_only |
| KIAA0100 | URGCP | 0.008 | 0.082 | bioplex_WMM WMM_only |
| VPS13B | URGCP | 0.008 | 0.046 | bioplex_WMM WMM_only |
| KIAA0100 | EML5 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| BAG2 | URGCP | 0.008 | 0.01 | bioplex_WMM boldt boldt_WMM |
| VPS13B | EML5 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| BAG2 | KIAA0100 | 0.007 | 0.01 | hein_WMM bioplex_WMM WMM_only |
| KIAA0100 | STUB1 | 0.007 | 0.012 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| BAG5 | URGCP | 0.007 | 0.006 | bioplex_WMM WMM_only |
| STUB1 | URGCP | 0.007 | 0.008 | boldt youn_WMM boldt_WMM |
| STUB1 | VPS13B | 0.007 | 0.004 | hein_WMM bioplex_WMM WMM_only |
| BAG2 | EML5 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| STUB1 | EML5 | 0.007 | 0.001 | WMM_only boldt_WMM |
| BAG5 | EML5 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| BAG5 | KIAA0100 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| BAG2 | VPS13B | 0.007 | 0.004 | hein_WMM bioplex_WMM WMM_only |
| BAG5 | VPS13B | 0.006 | 0.005 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02851 has an average edge precision of 0.152 which is ranked 6693 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| VPS13B | HuMAP2_02091 HuMAP2_02851 |
| STUB1 | HuMAP2_02091 HuMAP2_02851 HuMAP2_04364 HuMAP2_05456 |
| DNAJC7 | HuMAP2_00457 HuMAP2_02047 HuMAP2_02091 HuMAP2_02851 |
| URGCP | HuMAP2_02851 |
| KIAA0100 | HuMAP2_02091 HuMAP2_02851 HuMAP2_04125 HuMAP2_04775 |
| BAG5 | HuMAP2_00792 HuMAP2_02851 |
| BAG2 | HuMAP2_00457 HuMAP2_02091 HuMAP2_02851 HuMAP2_05029 |
| EML5 | HuMAP2_02091 HuMAP2_02851 |