hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02854
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CLASP1 | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | UniProt NCBI |
| CLASP2 | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | UniProt NCBI |
| ARHGEF38 | Rho guanine nucleotide exchange factor 38 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428890 | 0.000187420766709 | 0.666666666667 | CLASP1 CLASP2 | Role of ABL in ROBO-SLIT signaling |
| REAC:R-HSA-194315 | 0.00591618280835 | 1.0 | CLASP1 ARHGEF38 CLASP2 | Signaling by Rho GTPases |
| GO:1903690 | 0.00811409485621 | 0.666666666667 | CLASP1 CLASP2 | negative regulation of wound healing, spreading of epidermal cells |
| GO:2001197 | 0.0135228859698 | 0.666666666667 | CLASP1 CLASP2 | basement membrane assembly involved in embryonic body morphogenesis |
| GO:1904261 | 0.0135228859698 | 0.666666666667 | CLASP1 CLASP2 | positive regulation of basement membrane assembly involved in embryonic body morphogenesis |
| GO:1904259 | 0.0135228859698 | 0.666666666667 | CLASP1 CLASP2 | regulation of basement membrane assembly involved in embryonic body morphogenesis |
| GO:0045180 | 0.0135228859698 | 0.666666666667 | CLASP1 CLASP2 | basal cortex |
| GO:0110011 | 0.0135228859698 | 0.666666666667 | CLASP1 CLASP2 | regulation of basement membrane organization |
| GO:1903689 | 0.020283420769 | 0.666666666667 | CLASP1 CLASP2 | regulation of wound healing, spreading of epidermal cells |
| REAC:R-HSA-141444 | 0.0279140119136 | 0.666666666667 | CLASP1 CLASP2 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 0.0279140119136 | 0.666666666667 | CLASP1 CLASP2 | Amplification of signal from the kinetochores |
| GO:0090091 | 0.0283955176165 | 0.666666666667 | CLASP1 CLASP2 | positive regulation of extracellular matrix disassembly |
| GO:0005828 | 0.0283955176165 | 0.666666666667 | CLASP1 CLASP2 | kinetochore microtubule |
| REAC:R-HSA-69618 | 0.037791121028 | 0.666666666667 | CLASP1 CLASP2 | Mitotic Spindle Checkpoint |
| GO:0010172 | 0.0378589948753 | 0.666666666667 | CLASP1 CLASP2 | embryonic body morphogenesis |
| GO:0002162 | 0.0378589948753 | 0.666666666667 | CLASP1 CLASP2 | dystroglycan binding |
| REAC:R-HSA-2500257 | 0.0475526064057 | 0.666666666667 | CLASP1 CLASP2 | Resolution of Sister Chromatid Cohesion |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ARHGEF38 | CLASP1 | 0.238 | 0.47 | bioplex (ARHGEF38) bioplex_WMM |
| CLASP2 | CLASP1 | 0.155 | 0.416 | hein_WMM boldt youn_WMM hein (CLASP2) gupta_WMM boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_02854 has an average edge precision of 0.443 which is ranked 2920 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CLASP1 | HuMAP2_02854 HuMAP2_06276 |
| CLASP2 | HuMAP2_01478 HuMAP2_02854 |
| ARHGEF38 | HuMAP2_02854 HuMAP2_06276 |