hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02855
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CACYBP | Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein) | UniProt NCBI |
| NARS1 | Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) | UniProt NCBI |
| FKBP4 | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | UniProt NCBI |
| EZR | Ezrin (Cytovillin) (Villin-2) (p81) | UniProt NCBI |
| CDV3 | Protein CDV3 homolog | UniProt NCBI |
| EIF5A2 | Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) | UniProt NCBI |
| TPD52L2 | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | UniProt NCBI |
| MSN | Moesin (Membrane-organizing extension spike protein) | UniProt NCBI |
| YARS | Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed] | UniProt NCBI |
| ACAA2 | 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-) (EC 3.1.2.1) (EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1) | UniProt NCBI |
| CRK | Adapter molecule crk (Proto-oncogene c-Crk) (p38) | UniProt NCBI |
| RDX | Radixin | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP51 | 0.000185839444712 | 0.333333333333 | CRK MSN RDX EZR | Regulation of Actin Cytoskeleton |
| GO:1905668 | 0.00039905855691 | 0.25 | MSN RDX EZR | positive regulation of protein localization to endosome |
| GO:1902965 | 0.00039905855691 | 0.25 | MSN RDX EZR | regulation of protein localization to early endosome |
| GO:1902966 | 0.00039905855691 | 0.25 | MSN RDX EZR | positive regulation of protein localization to early endosome |
| KEGG:04810 | 0.000500461164633 | 0.333333333333 | CRK MSN RDX EZR | Regulation of actin cytoskeleton |
| GO:1905666 | 0.000698035893352 | 0.25 | MSN RDX EZR | regulation of protein localization to endosome |
| GO:2000643 | 0.00111635111712 | 0.25 | MSN RDX EZR | positive regulation of early endosome to late endosome transport |
| REAC:R-HSA-437239 | 0.00134380213021 | 0.25 | MSN RDX EZR | Recycling pathway of L1 |
| GO:1902946 | 0.00167376753379 | 0.25 | MSN RDX EZR | protein localization to early endosome |
| GO:1903651 | 0.0043777173151 | 0.25 | MSN RDX EZR | positive regulation of cytoplasmic transport |
| KEGG:04530 | 0.00847448371822 | 0.25 | MSN RDX EZR | Tight junction |
| KEGG:05206 | 0.0107159757517 | 0.25 | EZR RDX CRK | MicroRNAs in cancer |
| GO:2000641 | 0.0161932278671 | 0.25 | MSN RDX EZR | regulation of early endosome to late endosome transport |
| KEGG:05205 | 0.0181995337666 | 0.25 | MSN RDX EZR | Proteoglycans in cancer |
| GO:0036010 | 0.0192207384294 | 0.25 | MSN RDX EZR | protein localization to endosome |
| REAC:R-HSA-373760 | 0.0203856887088 | 0.25 | MSN RDX EZR | L1CAM interactions |
| KEGG:00970 | 0.0251120616417 | 0.166666666667 | NARS1 YARS | Aminoacyl-tRNA biosynthesis |
| GO:1903649 | 0.0350652467019 | 0.25 | MSN RDX EZR | regulation of cytoplasmic transport |
| REAC:R-HSA-379716 | 0.0392835928601 | 0.166666666667 | NARS1 YARS | Cytosolic tRNA aminoacylation |
| MIRNA:hsa-miR-664b-5p | 0.0434724503952 | 0.166666666667 | MSN CRK | hsa-miR-664b-5p |
| GO:0008360 | 0.0454340466991 | 0.333333333333 | CRK MSN RDX EZR | regulation of cell shape |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TPD52L2 | EZR | 0.999 | 0.946 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| EZR | RDX | 0.989 | 0.906 | hein_WMM bioplex_WMM youn_WMM hein (EZR) gupta_WMM treiber_WMM |
| MSN | EZR | 0.965 | 0.874 | hein_WMM bioplex_WMM hein (EZR,MSN) gupta_WMM treiber_WMM |
| CACYBP | MSN | 0.961 | 0.869 | bioplex_WMM Guru gupta_WMM fraction |
| CACYBP | EZR | 0.901 | 0.826 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| CDV3 | MSN | 0.891 | 0.818 | bioplex_WMM gupta_WMM fraction |
| MSN | RDX | 0.89 | 0.818 | hein_WMM bioplex_WMM hein (MSN) treiber_WMM |
| EZR | ACAA2 | 0.748 | 0.742 | bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| ACAA2 | RDX | 0.744 | 0.74 | bioplex_WMM Guru gupta_WMM fraction |
| CRK | FKBP4 | 0.599 | 0.669 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| CRK | EZR | 0.544 | 0.643 | bioplex_WMM gupta_WMM fraction |
| MSN | ACAA2 | 0.468 | 0.604 | bioplex_WMM Guru fraction |
| FKBP4 | MSN | 0.414 | 0.571 | bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| CACYBP | RDX | 0.293 | 0.494 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| MSN | YARS | 0.267 | 0.483 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| FKBP4 | CDV3 | 0.199 | 0.452 | bioplex_WMM youn_WMM gupta_WMM fraction |
| CRK | CDV3 | 0.196 | 0.449 | bioplex_WMM gupta_WMM fraction |
| EIF5A2 | EZR | 0.164 | 0.42 | Guru gupta_WMM fraction |
| CACYBP | FKBP4 | 0.162 | 0.419 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| YARS | EZR | 0.154 | 0.415 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| CACYBP | TPD52L2 | 0.15 | 0.41 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| YARS | RDX | 0.128 | 0.399 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| TPD52L2 | MSN | 0.124 | 0.395 | bioplex_WMM Guru gupta_WMM fraction |
| FKBP4 | TPD52L2 | 0.107 | 0.373 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| TPD52L2 | RDX | 0.107 | 0.373 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| EIF5A2 | RDX | 0.096 | 0.358 | Guru gupta_WMM fraction |
| NARS1 | EZR | 0.051 | 0.3 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| CRK | YARS | 0.043 | 0.269 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| FKBP4 | EZR | 0.037 | 0.268 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| CRK | MSN | 0.032 | 0.245 | bioplex_WMM gupta_WMM fraction |
| CDV3 | YARS | 0.021 | 0.186 | bioplex_WMM youn_WMM gupta_WMM fraction |
| CACYBP | CDV3 | 0.02 | 0.187 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| CACYBP | YARS | 0.02 | 0.19 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| TPD52L2 | YARS | 0.016 | 0.154 | bioplex_WMM youn_WMM gupta_WMM fraction |
| FKBP4 | YARS | 0.015 | 0.14 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| CRK | TPD52L2 | 0.012 | 0.147 | bioplex_WMM boldt gupta_WMM boldt_WMM |
| CACYBP | NARS1 | 0.011 | 0.144 | bioplex_WMM youn_WMM gupta_WMM fraction |
| NARS1 | RDX | 0.008 | 0.033 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| CRK | CACYBP | 0.008 | 0.028 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM |
| CDV3 | RDX | 0.008 | 0.016 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CDV3 | EZR | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CRK | RDX | 0.007 | 0.004 | bioplex_WMM gupta_WMM fraction |
| EIF5A2 | MSN | 0.007 | 0.003 | Guru fraction |
| NARS1 | MSN | 0.006 | 0.003 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| CRK | ACAA2 | 0.006 | 0.008 | bioplex_WMM gupta_WMM WMM_only |
| CACYBP | ACAA2 | 0.006 | 0.012 | bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| FKBP4 | RDX | 0.004 | 0.007 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| CDV3 | ACAA2 | 0.003 | 0.021 | bioplex_WMM WMM_only |
| YARS | ACAA2 | 0.003 | 0.011 | bioplex_WMM gupta_WMM WMM_only |
| CRK | EIF5A2 | 0.0 | 0.005 | gupta_WMM fraction |
| CDV3 | TPD52L2 | 0.0 | 0.01 | bioplex_WMM youn_WMM gupta_WMM fraction |
| CACYBP | EIF5A2 | 0.0 | 0.011 | Guru gupta_WMM fraction |
| EIF5A2 | YARS | 0.0 | 0.006 | gupta_WMM fraction |
| NARS1 | CDV3 | 0.0 | 0.001 | bioplex_WMM youn_WMM gupta_WMM fraction |
| NARS1 | TPD52L2 | 0.0 | 0.003 | bioplex_WMM youn_WMM gupta_WMM fraction |
| EIF5A2 | ACAA2 | 0.0 | 0.0 | Guru fraction |
| TPD52L2 | ACAA2 | 0.0 | 0.002 | bioplex_WMM Guru gupta_WMM fraction |
| FKBP4 | ACAA2 | 0.0 | 0.0 | bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| EIF5A2 | TPD52L2 | 0.0 | 0.0 | Guru fraction |
| FKBP4 | NARS1 | 0.0 | 0.001 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| NARS1 | ACAA2 | 0.0 | 0.003 | bioplex_WMM gupta_WMM fraction |
| EIF5A2 | FKBP4 | 0.0 | 0.0 | Guru gupta_WMM fraction |
| CRK | NARS1 | 0.0 | 0.001 | bioplex_WMM gupta_WMM fraction |
| NARS1 | YARS | 0.0 | 0.001 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| EIF5A2 | NARS1 | 0.0 | 0.001 | fraction |
Images
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Complex HuMAP2_02855 has an average edge precision of 0.275 which is ranked 4950 out of all 6965 complexes.
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