hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02856
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PLOD1 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1) | UniProt NCBI |
| COL13A1 | Collagen alpha-1(XIII) chain (COLXIIIA1) | UniProt NCBI |
| COL4A1 | Collagen alpha-1(IV) chain [Cleaved into: Arresten] | UniProt NCBI |
| COL4A6 | Collagen alpha-6(IV) chain | UniProt NCBI |
| COL25A1 | Collagen alpha-1(XXV) chain (Alzheimer disease amyloid-associated protein) (AMY) (CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component (CLAC)] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1650814 | 1.58712520861e-10 | 1.0 | COL4A6 PLOD1 COL25A1 COL13A1 COL4A1 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 7.57189610424e-10 | 1.0 | COL4A6 PLOD1 COL25A1 COL13A1 COL4A1 | Collagen formation |
| REAC:R-HSA-8948216 | 2.99818273785e-08 | 0.8 | COL4A6 COL25A1 COL13A1 COL4A1 | Collagen chain trimerization |
| REAC:R-HSA-1442490 | 1.77549959727e-07 | 0.8 | COL4A6 COL25A1 COL13A1 COL4A1 | Collagen degradation |
| REAC:R-HSA-1474244 | 2.67089525702e-07 | 1.0 | COL4A6 PLOD1 COL25A1 COL13A1 COL4A1 | Extracellular matrix organization |
| REAC:R-HSA-1474228 | 3.87002996107e-06 | 0.8 | COL4A6 COL25A1 COL13A1 COL4A1 | Degradation of the extracellular matrix |
| GO:0030020 | 7.17274954203e-06 | 0.8 | COL4A6 COL25A1 COL13A1 COL4A1 | extracellular matrix structural constituent conferring tensile strength |
| KEGG:04974 | 5.79822076286e-05 | 0.6 | COL4A6 COL13A1 COL4A1 | Protein digestion and absorption |
| REAC:R-HSA-216083 | 0.00018227939524 | 0.6 | COL4A6 COL13A1 COL4A1 | Integrin cell surface interactions |
| GO:0005201 | 0.001292590007 | 0.8 | COL4A6 COL25A1 COL13A1 COL4A1 | extracellular matrix structural constituent |
| REAC:R-HSA-2214320 | 0.00141478632427 | 0.4 | COL4A1 COL4A6 | Anchoring fibril formation |
| HP:0000482 | 0.00205426749297 | 0.6 | COL25A1 COL4A1 PLOD1 | Microcornea |
| REAC:R-HSA-2243919 | 0.00206071490935 | 0.4 | COL4A1 COL4A6 | Crosslinking of collagen fibrils |
| GO:0005581 | 0.00367721278555 | 0.6 | COL4A6 COL13A1 COL4A1 | collagen trimer |
| HP:0001120 | 0.00370466652798 | 0.6 | COL25A1 COL4A1 PLOD1 | Abnormality of corneal size |
| REAC:R-HSA-3000157 | 0.00584945327803 | 0.4 | COL4A1 COL4A6 | Laminin interactions |
| KEGG:04512 | 0.0127624438559 | 0.4 | COL4A1 COL4A6 | ECM-receptor interaction |
| HP:0001291 | 0.0141499625944 | 0.6 | COL25A1 COL13A1 COL4A1 | Abnormal cranial nerve morphology |
| WP:WP4658 | 0.0147251965341 | 0.4 | COL4A1 COL4A6 | Small cell lung cancer |
| HP:0007676 | 0.0150562782431 | 0.4 | COL25A1 COL4A1 | Hypoplasia of the iris |
| KEGG:05146 | 0.0151578406027 | 0.4 | COL4A1 COL4A6 | Amoebiasis |
| GO:0005788 | 0.0165084833157 | 0.8 | COL4A6 COL25A1 COL13A1 COL4A1 | endoplasmic reticulum lumen |
| KEGG:04933 | 0.0173728888545 | 0.4 | COL4A1 COL4A6 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:05222 | 0.0177565608839 | 0.4 | COL4A1 COL4A6 | Small cell lung cancer |
| GO:0030198 | 0.0200611173853 | 0.8 | COL4A6 PLOD1 COL13A1 COL4A1 | extracellular matrix organization |
| HP:0025323 | 0.0201414164419 | 0.4 | COL4A1 PLOD1 | Abnormal arterial physiology |
| REAC:R-HSA-2022090 | 0.0206361227401 | 0.4 | COL4A1 COL4A6 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-3000171 | 0.0213836497757 | 0.4 | COL4A1 COL4A6 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-3000178 | 0.0287045163353 | 0.4 | COL4A1 COL4A6 | ECM proteoglycans |
| WP:WP4239 | 0.0296692241758 | 0.4 | COL4A1 COL4A6 | Epithelial to mesenchymal transition in colorectal cancer |
| KEGG:04926 | 0.0301730300338 | 0.4 | COL4A1 COL4A6 | Relaxin signaling pathway |
| HP:0000615 | 0.0325153883173 | 0.4 | COL25A1 COL4A1 | Abnormal pupil morphology |
| HP:0000504 | 0.0360700347925 | 0.8 | PLOD1 COL25A1 COL13A1 COL4A1 | Abnormality of vision |
| GO:0043062 | 0.0361255742156 | 0.8 | COL4A6 PLOD1 COL13A1 COL4A1 | extracellular structure organization |
| GO:0062023 | 0.0413212587053 | 0.8 | COL4A6 COL25A1 COL13A1 COL4A1 | collagen-containing extracellular matrix |
| GO:0044432 | 0.0440230022293 | 1.0 | COL4A6 PLOD1 COL25A1 COL13A1 COL4A1 | endoplasmic reticulum part |
| HP:0001760 | 0.0458823387011 | 0.8 | PLOD1 COL25A1 COL13A1 COL4A1 | Abnormality of the foot |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| COL4A1 | PLOD1 | 0.854 | 0.793 | hein_WMM bioplex (PLOD1) bioplex_WMM |
| PLOD1 | COL4A6 | 0.524 | 0.635 | bioplex (PLOD1) bioplex_WMM |
| PLOD1 | COL13A1 | 0.115 | 0.385 | bioplex (PLOD1) bioplex_WMM |
| PLOD1 | COL25A1 | 0.073 | 0.355 | bioplex (PLOD1) bioplex_WMM gupta_WMM |
| COL4A1 | COL4A6 | 0.011 | 0.145 | bioplex_WMM WMM_only |
| COL13A1 | COL25A1 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| COL4A6 | COL25A1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| COL13A1 | COL4A6 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| COL4A1 | COL25A1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| COL4A1 | COL13A1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02856 has an average edge precision of 0.274 which is ranked 4964 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PLOD1 | HuMAP2_02722 HuMAP2_02856 HuMAP2_04238 HuMAP2_04483 HuMAP2_05080 |
| COL13A1 | HuMAP2_02856 HuMAP2_05080 |
| COL4A1 | HuMAP2_01361 HuMAP2_02856 HuMAP2_04238 HuMAP2_04483 HuMAP2_05080 HuMAP2_05564 |
| COL4A6 | HuMAP2_02856 HuMAP2_04238 HuMAP2_05080 |
| COL25A1 | HuMAP2_02856 HuMAP2_05080 |