hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02878
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CFAP410 | Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2) | UniProt NCBI |
| NEK1 | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0030195 | 0.00198696244274 | 1.0 | NEK1 CFAP410 | Fatigable weakness of swallowing muscles |
| HP:0025425 | 0.00210384258643 | 1.0 | NEK1 CFAP410 | Laryngospasm |
| HP:0025424 | 0.00301550770722 | 1.0 | NEK1 CFAP410 | Abnormal larynx physiology |
| HP:0007354 | 0.00301550770722 | 1.0 | NEK1 CFAP410 | Amyotrophic lateral sclerosis |
| HP:0000217 | 0.00376688005952 | 1.0 | NEK1 CFAP410 | Xerostomia |
| HP:0030192 | 0.00392717282801 | 1.0 | NEK1 CFAP410 | Fatigable weakness of bulbar muscles |
| HP:0030196 | 0.00425777666302 | 1.0 | NEK1 CFAP410 | Fatigable weakness of respiratory muscles |
| HP:0007373 | 0.00460173822874 | 1.0 | NEK1 CFAP410 | Motor neuron atrophy |
| HP:0002450 | 0.00694601996791 | 1.0 | NEK1 CFAP410 | Abnormal motor neuron morphology |
| HP:0012757 | 0.00738348564858 | 1.0 | NEK1 CFAP410 | Abnormal neuron morphology |
| HP:0002180 | 0.00738348564858 | 1.0 | NEK1 CFAP410 | Neurodegeneration |
| HP:0000713 | 0.0108197618731 | 1.0 | NEK1 CFAP410 | Agitation |
| HP:0000926 | 0.0130772183627 | 1.0 | NEK1 CFAP410 | Platyspondyly |
| HP:0003473 | 0.0142860929917 | 1.0 | NEK1 CFAP410 | Fatigable weakness |
| HP:0012535 | 0.0145966602306 | 1.0 | NEK1 CFAP410 | Abnormal synaptic transmission |
| HP:0030191 | 0.0145966602306 | 1.0 | NEK1 CFAP410 | Abnormal peripheral nervous system synaptic transmission |
| HP:0003398 | 0.0145966602306 | 1.0 | NEK1 CFAP410 | Abnormal synaptic transmission at the neuromuscular junction |
| HP:0000711 | 0.0145966602306 | 1.0 | NEK1 CFAP410 | Restlessness |
| HP:0003324 | 0.0168641350182 | 1.0 | NEK1 CFAP410 | Generalized muscle weakness |
| HP:0000712 | 0.0175420398516 | 1.0 | NEK1 CFAP410 | Emotional lability |
| HP:0003470 | 0.0185839428468 | 1.0 | NEK1 CFAP410 | Paralysis |
| HP:0005257 | 0.0200198988979 | 1.0 | NEK1 CFAP410 | Thoracic hypoplasia |
| HP:0100755 | 0.0250557633746 | 1.0 | NEK1 CFAP410 | Abnormality of salivation |
| HP:0003394 | 0.0271429087977 | 1.0 | NEK1 CFAP410 | Muscle spasm |
| HP:0001600 | 0.0306559919738 | 1.0 | NEK1 CFAP410 | Abnormality of the larynx |
| HP:0002878 | 0.032028498804 | 1.0 | NEK1 CFAP410 | Respiratory failure |
| HP:0005766 | 0.0497341708567 | 0.5 | NEK1 | Disproportionate shortening of the tibia |
| HP:0006436 | 0.0497341708567 | 0.5 | NEK1 | Shortening of the tibia |
| HP:0005873 | 0.0497341708567 | 0.5 | NEK1 | Polysyndactyly of hallux |
| HP:0010100 | 0.0497341708567 | 0.5 | NEK1 | Complete duplication of hallux phalanx |
| HP:0410033 | 0.0497341708567 | 0.5 | NEK1 | Unilateral alveolar cleft of maxilla |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NEK1 | CFAP410 | 0.998 | 0.943 | hein_WMM bioplex_WMM boldt (CFAP410,NEK1) hein (NEK1) gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_02878 has an average edge precision of 0.943 which is ranked 373 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CFAP410 | HuMAP2_00805 HuMAP2_01908 HuMAP2_02878 HuMAP2_06049 |
| NEK1 | HuMAP2_00805 HuMAP2_01908 HuMAP2_02878 HuMAP2_06049 HuMAP2_06217 |