hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02885
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TMED5 | Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2) (p28) | UniProt NCBI |
| TMED1 | Transmembrane emp24 domain-containing protein 1 (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor-binding protein) (p24 family protein gamma-1) (Tp24) (p24gamma1) | UniProt NCBI |
| TMED3 | Transmembrane emp24 domain-containing protein 3 (Membrane protein p24B) (p24 family protein gamma-4) (p24gamma4) (p26) | UniProt NCBI |
| TMED10 | Transmembrane emp24 domain-containing protein 10 (21 kDa transmembrane-trafficking protein) (S31III125) (S31I125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta) | UniProt NCBI |
| TMED9 | Transmembrane emp24 domain-containing protein 9 (GMP25) (Glycoprotein 25L2) (p24 family protein alpha-2) (p24alpha2) (p25) | UniProt NCBI |
| TMED4 | Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3) | UniProt NCBI |
| TMED2 | Transmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030134 | 2.52899247896e-12 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | COPII-coated ER to Golgi transport vesicle |
| GO:0005793 | 7.03025239509e-12 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | endoplasmic reticulum-Golgi intermediate compartment |
| GO:0007030 | 8.18329113946e-11 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | Golgi organization |
| GO:0005798 | 2.26527369424e-10 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | Golgi-associated vesicle |
| GO:0006888 | 1.88461586906e-09 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| GO:0030135 | 4.84652257096e-09 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | coated vesicle |
| GO:0048193 | 1.25766036784e-07 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | Golgi vesicle transport |
| GO:0010256 | 1.31233506018e-07 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | endomembrane system organization |
| REAC:R-HSA-6811434 | 9.34645756121e-06 | 0.571428571429 | TMED10 TMED3 TMED9 TMED2 | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6807878 | 9.74687731254e-06 | 0.571428571429 | TMED10 TMED3 TMED9 TMED2 | COPI-mediated anterograde transport |
| REAC:R-HSA-8856688 | 3.17830201784e-05 | 0.571428571429 | TMED10 TMED3 TMED9 TMED2 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-199977 | 4.79587526056e-05 | 0.571428571429 | TMED10 TMED3 TMED9 TMED2 | ER to Golgi Anterograde Transport |
| GO:0033116 | 5.60927563414e-05 | 0.571428571429 | TMED10 TMED3 TMED9 TMED2 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| GO:0048205 | 6.35345863999e-05 | 0.428571428571 | TMED10 TMED9 TMED2 | COPI coating of Golgi vesicle |
| GO:0048200 | 6.35345863999e-05 | 0.428571428571 | TMED10 TMED9 TMED2 | Golgi transport vesicle coating |
| GO:0035964 | 6.35345863999e-05 | 0.428571428571 | TMED10 TMED9 TMED2 | COPI-coated vesicle budding |
| REAC:R-HSA-948021 | 9.11840957805e-05 | 0.571428571429 | TMED10 TMED3 TMED9 TMED2 | Transport to the Golgi and subsequent modification |
| GO:0006886 | 0.000166634167312 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | intracellular protein transport |
| REAC:R-HSA-6811442 | 0.00016845334948 | 0.571428571429 | TMED10 TMED3 TMED9 TMED2 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0005794 | 0.000453965088566 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | Golgi apparatus |
| REAC:R-HSA-446203 | 0.000734322285617 | 0.571428571429 | TMED10 TMED3 TMED9 TMED2 | Asparagine N-linked glycosylation |
| MIRNA:hsa-miR-30a-5p | 0.00123697717746 | 0.714285714286 | TMED10 TMED3 TMED1 TMED5 TMED2 | hsa-miR-30a-5p |
| GO:0006890 | 0.00170638130272 | 0.571428571429 | TMED10 TMED3 TMED9 TMED2 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| GO:0005783 | 0.00203891214571 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | endoplasmic reticulum |
| GO:0015031 | 0.00215038892806 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | protein transport |
| GO:0015833 | 0.00237664126968 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | peptide transport |
| GO:0042886 | 0.00259607662238 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | amide transport |
| GO:0046907 | 0.00363859974134 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | intracellular transport |
| GO:0045184 | 0.0036745489957 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | establishment of protein localization |
| GO:0030137 | 0.00487641079113 | 0.428571428571 | TMED10 TMED2 TMED3 | COPI-coated vesicle |
| GO:0034613 | 0.00546147189892 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | cellular protein localization |
| GO:0070727 | 0.00569376331345 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | cellular macromolecule localization |
| GO:0071705 | 0.00632623715462 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | nitrogen compound transport |
| GO:0016192 | 0.00644216001439 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | vesicle-mediated transport |
| GO:0031410 | 0.00667947733575 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | cytoplasmic vesicle |
| GO:0097708 | 0.00670966219137 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | intracellular vesicle |
| REAC:R-HSA-5694530 | 0.0110517363252 | 0.285714285714 | TMED10 TMED2 | Cargo concentration in the ER |
| REAC:R-HSA-199991 | 0.0122104245536 | 0.571428571429 | TMED10 TMED3 TMED9 TMED2 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0150589916515 | 0.571428571429 | TMED10 TMED3 TMED9 TMED2 | Vesicle-mediated transport |
| GO:0051649 | 0.015479871164 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | establishment of localization in cell |
| HPA:039010_23 | 0.0169629817054 | 0.571428571429 | TMED2 TMED9 TMED5 TMED4 | salivary gland; glandular cells[Approved,High] |
| GO:0071702 | 0.0180623174395 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | organic substance transport |
| GO:0008104 | 0.0342210950981 | 1.0 | TMED4 TMED3 TMED9 TMED10 TMED2 TMED5 TMED1 | protein localization |
| HPA:015010_23 | 0.0426115752027 | 0.571428571429 | TMED3 TMED2 TMED9 TMED4 | epididymis; glandular cells[Approved,High] |
| HPA:028010_22 | 0.0428361103513 | 0.714285714286 | TMED3 TMED2 TMED9 TMED5 TMED4 | lymph node; germinal center cells[Approved,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TMED10 | TMED2 | 1.0 | 0.949 | hein_WMM bioplex (TMED10) bioplex_WMM Guru boldt hein (TMED10,TMED2) gupta_WMM fraction boldt_WMM treiber_WMM |
| TMED4 | TMED2 | 1.0 | 0.949 | hein_WMM bioplex (TMED2) bioplex_WMM Guru boldt hein (TMED2) fraction boldt_WMM treiber_WMM |
| TMED10 | TMED9 | 1.0 | 0.949 | hein_WMM bioplex (TMED10) bioplex_WMM Guru boldt hein (TMED10) gupta_WMM fraction boldt_WMM treiber_WMM |
| TMED10 | TMED4 | 1.0 | 0.949 | hein_WMM bioplex (TMED10) bioplex_WMM Guru boldt hein (TMED10) fraction boldt_WMM treiber_WMM |
| TMED1 | TMED2 | 0.999 | 0.949 | hein_WMM bioplex (TMED2) bioplex_WMM boldt hein (TMED2) boldt_WMM |
| TMED10 | TMED1 | 0.999 | 0.945 | hein_WMM bioplex (TMED10) bioplex_WMM boldt hein (TMED10) boldt_WMM |
| TMED2 | TMED9 | 0.997 | 0.934 | hein_WMM bioplex_WMM Guru boldt hein (TMED2) gupta_WMM fraction boldt_WMM treiber_WMM |
| TMED2 | TMED3 | 0.994 | 0.923 | hein_WMM bioplex (TMED2,TMED3) bioplex_WMM hein (TMED2) fraction |
| TMED2 | TMED5 | 0.992 | 0.911 | hein_WMM bioplex (TMED2) bioplex_WMM boldt hein (TMED2) gupta_WMM boldt_WMM |
| TMED10 | TMED5 | 0.984 | 0.899 | hein_WMM bioplex (TMED10) bioplex_WMM boldt hein (TMED10) gupta_WMM boldt_WMM |
| TMED10 | TMED3 | 0.885 | 0.817 | hein_WMM bioplex (TMED10,TMED3) bioplex_WMM hein (TMED10) fraction |
| TMED4 | TMED9 | 0.024 | 0.214 | hein_WMM bioplex_WMM boldt boldt_WMM treiber_WMM |
| TMED1 | TMED4 | 0.023 | 0.205 | hein_WMM bioplex_WMM boldt boldt_WMM |
| TMED1 | TMED5 | 0.021 | 0.193 | hein_WMM bioplex_WMM boldt boldt_WMM |
| TMED5 | TMED9 | 0.018 | 0.178 | hein_WMM bioplex_WMM boldt gupta_WMM boldt_WMM |
| TMED1 | TMED9 | 0.016 | 0.158 | hein_WMM bioplex_WMM boldt boldt_WMM |
| TMED4 | TMED5 | 0.016 | 0.154 | hein_WMM bioplex_WMM boldt boldt_WMM |
| TMED9 | TMED3 | 0.011 | 0.142 | hein_WMM bioplex_WMM WMM_only |
| TMED5 | TMED3 | 0.01 | 0.137 | hein_WMM bioplex_WMM WMM_only |
| TMED1 | TMED3 | 0.01 | 0.131 | hein_WMM bioplex_WMM WMM_only |
| TMED4 | TMED3 | 0.003 | 0.018 | hein_WMM bioplex (TMED3) bioplex_WMM |
Images
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Complex HuMAP2_02885 has an average edge precision of 0.557 which is ranked 2150 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TMED5 | HuMAP2_00162 HuMAP2_02885 HuMAP2_06043 |
| TMED1 | HuMAP2_00162 HuMAP2_02885 HuMAP2_06043 |
| TMED3 | HuMAP2_00162 HuMAP2_02885 HuMAP2_05043 |
| TMED10 | HuMAP2_00162 HuMAP2_02885 HuMAP2_06043 |
| TMED9 | HuMAP2_00162 HuMAP2_02885 HuMAP2_06043 |
| TMED4 | HuMAP2_00162 HuMAP2_02885 HuMAP2_06043 |
| TMED2 | HuMAP2_00162 HuMAP2_02885 |