hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02888

Confidence: Medium High

Genename	Protein Name	Links
H2BC13	Histone H2B type 1-L (Histone H2B.c) (H2B/c)	UniProt NCBI
H2BC1	Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B)	UniProt NCBI
H2AZ1	Histone H2A.Z (H2A/z)	UniProt NCBI
H2AFY2	Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)	UniProt NCBI
BAHD1	Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:05322	7.43603770459e-07	0.8	H2AFY2 H2AZ1 H2BC1 H2BC13	Systemic lupus erythematosus
KEGG:05034	3.51323493939e-06	0.8	H2AFY2 H2AZ1 H2BC1 H2BC13	Alcoholism
REAC:R-HSA-171306	5.63522070511e-05	0.6	H2BC13 H2AZ1 H2BC1	Packaging Of Telomere Ends
REAC:R-HSA-110331	6.70990066737e-05	0.6	H2BC13 H2AZ1 H2BC1	Cleavage of the damaged purine
REAC:R-HSA-110330	6.70990066737e-05	0.6	H2BC13 H2AZ1 H2BC1	Recognition and association of DNA glycosylase with site containing an affected purine
REAC:R-HSA-73927	6.70990066737e-05	0.6	H2BC13 H2AZ1 H2BC1	Depurination
REAC:R-HSA-110328	8.34369774361e-05	0.6	H2BC13 H2AZ1 H2BC1	Recognition and association of DNA glycosylase with site containing an affected pyrimidine
REAC:R-HSA-110329	8.34369774361e-05	0.6	H2BC13 H2AZ1 H2BC1	Cleavage of the damaged pyrimidine
REAC:R-HSA-73928	8.34369774361e-05	0.6	H2BC13 H2AZ1 H2BC1	Depyrimidination
REAC:R-HSA-73929	8.78979375366e-05	0.6	H2BC13 H2AZ1 H2BC1	Base-Excision Repair, AP Site Formation
REAC:R-HSA-73728	0.00010222685444	0.6	H2BC13 H2AZ1 H2BC1	RNA Polymerase I Promoter Opening
REAC:R-HSA-5334118	0.000112594374126	0.6	H2BC13 H2AZ1 H2BC1	DNA methylation
REAC:R-HSA-5625886	0.000123638575202	0.6	H2BC13 H2AZ1 H2BC1	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
REAC:R-HSA-427359	0.00012942105654	0.6	H2BC13 H2AZ1 H2BC1	SIRT1 negatively regulates rRNA expression
REAC:R-HSA-774815	0.000161043167075	0.6	H2BC13 H2AZ1 H2BC1	Nucleosome assembly
REAC:R-HSA-2299718	0.000161043167075	0.6	H2BC13 H2AZ1 H2BC1	Condensation of Prophase Chromosomes
REAC:R-HSA-212300	0.000161043167075	0.6	H2BC13 H2AZ1 H2BC1	PRC2 methylates histones and DNA
REAC:R-HSA-606279	0.000161043167075	0.6	H2BC13 H2AZ1 H2BC1	Deposition of new CENPA-containing nucleosomes at the centromere
REAC:R-HSA-427389	0.00018227939524	0.6	H2BC13 H2AZ1 H2BC1	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
REAC:R-HSA-1221632	0.00018227939524	0.6	H2BC13 H2AZ1 H2BC1	Meiotic synapsis
REAC:R-HSA-2559586	0.000213382377717	0.6	H2BC13 H2AZ1 H2BC1	DNA Damage/Telomere Stress Induced Senescence
REAC:R-HSA-157579	0.00023017619861	0.6	H2BC13 H2AZ1 H2BC1	Telomere Maintenance
REAC:R-HSA-9616222	0.000247826336378	0.6	H2BC13 H2AZ1 H2BC1	Transcriptional regulation of granulopoiesis
REAC:R-HSA-912446	0.000266353842167	0.6	H2BC13 H2AZ1 H2BC1	Meiotic recombination
REAC:R-HSA-73884	0.000285779749786	0.6	H2BC13 H2AZ1 H2BC1	Base Excision Repair
REAC:R-HSA-5250924	0.000306125075711	0.6	H2BC13 H2AZ1 H2BC1	B-WICH complex positively regulates rRNA expression
REAC:R-HSA-201722	0.000306125075711	0.6	H2BC13 H2AZ1 H2BC1	Formation of the beta-catenin:TCF transactivating complex
REAC:R-HSA-73772	0.000316649083447	0.6	H2BC13 H2AZ1 H2BC1	RNA Polymerase I Promoter Escape
REAC:R-HSA-1912408	0.000327410819085	0.6	H2BC13 H2AZ1 H2BC1	Pre-NOTCH Transcription and Translation
REAC:R-HSA-8936459	0.000338412904811	0.6	H2BC13 H2AZ1 H2BC1	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
REAC:R-HSA-5625740	0.000349657961729	0.6	H2BC13 H2AZ1 H2BC1	RHO GTPases activate PKNs
REAC:R-HSA-977225	0.000448679555289	0.6	H2BC13 H2AZ1 H2BC1	Amyloid fiber formation
REAC:R-HSA-5578749	0.000462229124052	0.6	H2BC13 H2AZ1 H2BC1	Transcriptional regulation by small RNAs
REAC:R-HSA-5250913	0.000490138238949	0.6	H2BC13 H2AZ1 H2BC1	Positive epigenetic regulation of rRNA expression
REAC:R-HSA-427413	0.000504503002414	0.6	H2BC13 H2AZ1 H2BC1	NoRC negatively regulates rRNA expression
REAC:R-HSA-2559582	0.000519144712976	0.6	H2BC13 H2AZ1 H2BC1	Senescence-Associated Secretory Phenotype (SASP)
REAC:R-HSA-1912422	0.000534065976599	0.6	H2BC13 H2AZ1 H2BC1	Pre-NOTCH Expression and Processing
REAC:R-HSA-73886	0.000549269398166	0.6	H2BC13 H2AZ1 H2BC1	Chromosome Maintenance
REAC:R-HSA-5250941	0.000549269398166	0.6	H2BC13 H2AZ1 H2BC1	Negative epigenetic regulation of rRNA expression
REAC:R-HSA-73854	0.000564757581481	0.6	H2BC13 H2AZ1 H2BC1	RNA Polymerase I Promoter Clearance
REAC:R-HSA-73864	0.000580533129267	0.6	H2BC13 H2AZ1 H2BC1	RNA Polymerase I Transcription
REAC:R-HSA-1500620	0.000646560981801	0.6	H2BC13 H2AZ1 H2BC1	Meiosis
REAC:R-HSA-5619507	0.000663812355004	0.6	H2BC13 H2AZ1 H2BC1	Activation of HOX genes during differentiation
REAC:R-HSA-5617472	0.000663812355004	0.6	H2BC13 H2AZ1 H2BC1	Activation of anterior HOX genes in hindbrain development during early embryogenesis
REAC:R-HSA-2559580	0.000793200049211	0.6	H2BC13 H2AZ1 H2BC1	Oxidative Stress Induced Senescence
REAC:R-HSA-8939236	0.000874143100407	0.6	H2BC13 H2AZ1 H2BC1	RUNX1 regulates transcription of genes involved in differentiation of HSCs
REAC:R-HSA-1474165	0.000895201015071	0.6	H2BC13 H2AZ1 H2BC1	Reproduction
REAC:R-HSA-211000	0.00100555265154	0.6	H2BC13 H2AZ1 H2BC1	Gene Silencing by RNA
REAC:R-HSA-68875	0.00100555265154	0.6	H2BC13 H2AZ1 H2BC1	Mitotic Prophase
REAC:R-HSA-9018519	0.00122625830858	0.6	H2BC13 H2AZ1 H2BC1	Estrogen-dependent gene expression
REAC:R-HSA-212165	0.00136170542712	0.6	H2BC13 H2AZ1 H2BC1	Epigenetic regulation of gene expression
WP:WP4553	0.00186538306079	0.4	H2AFY2 H2AZ1	FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma
REAC:R-HSA-2559583	0.00290844270817	0.6	H2BC13 H2AZ1 H2BC1	Cellular Senescence
REAC:R-HSA-8939211	0.00371466203946	0.6	H2BC13 H2AZ1 H2BC1	ESR-mediated signaling
GO:0006325	0.00448062284804	1.0	H2AFY2 H2BC1 H2AZ1 H2BC13 BAHD1	chromatin organization
REAC:R-HSA-8878171	0.00459345384685	0.6	H2BC13 H2AZ1 H2BC1	Transcriptional regulation by RUNX1
REAC:R-HSA-157118	0.0046564839046	0.6	H2BC13 H2AZ1 H2BC1	Signaling by NOTCH
REAC:R-HSA-201681	0.00478425526644	0.6	H2BC13 H2AZ1 H2BC1	TCF dependent signaling in response to WNT
REAC:R-HSA-9006931	0.00634577840696	0.6	H2BC13 H2AZ1 H2BC1	Signaling by Nuclear Receptors
REAC:R-HSA-3247509	0.00849111810066	0.6	H2BC13 H2AZ1 H2BC1	Chromatin modifying enzymes
REAC:R-HSA-4839726	0.00849111810066	0.6	H2BC13 H2AZ1 H2BC1	Chromatin organization
REAC:R-HSA-195258	0.0128363146831	0.6	H2BC13 H2AZ1 H2BC1	RHO GTPase Effectors
REAC:R-HSA-195721	0.0129604262881	0.6	H2BC13 H2AZ1 H2BC1	Signaling by WNT
REAC:R-HSA-73894	0.0143782387474	0.6	H2BC13 H2AZ1 H2BC1	DNA Repair
REAC:R-HSA-8866654	0.0206361227401	0.4	H2BC13 H2BC1	E3 ubiquitin ligases ubiquitinate target proteins
REAC:R-HSA-68886	0.0231915667986	0.6	H2BC13 H2AZ1 H2BC1	M Phase
REAC:R-HSA-2262752	0.0291077226575	0.6	H2BC13 H2AZ1 H2BC1	Cellular responses to stress
REAC:R-HSA-5693571	0.0313816354582	0.4	H2BC13 H2BC1	Nonhomologous End-Joining (NHEJ)
REAC:R-HSA-194315	0.034259108007	0.6	H2BC13 H2AZ1 H2BC1	Signaling by Rho GTPases
REAC:R-HSA-8852135	0.0370902496619	0.4	H2BC13 H2BC1	Protein ubiquitination
REAC:R-HSA-5693565	0.0380875604325	0.4	H2BC13 H2BC1	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
REAC:R-HSA-5693606	0.0390979640759	0.4	H2BC13 H2BC1	DNA Double Strand Break Response
GO:0051276	0.046479053704	1.0	H2AFY2 H2BC1 H2AZ1 H2BC13 BAHD1	chromosome organization
MIRNA:hsa-miR-6839-3p	0.0482780268961	0.4	H2BC13 H2BC1	hsa-miR-6839-3p
MIRNA:hsa-miR-4507	0.0482780268961	0.4	H2BC13 H2BC1	hsa-miR-4507
KEGG:04217	0.0482876775804	0.4	H2AFY2 H2AZ1	Necroptosis
REAC:R-HSA-8953897	0.0498194225693	0.6	H2BC13 H2AZ1 H2BC1	Cellular responses to external stimuli

Edges

Protein 1	Protein 2	Score	Precision	Evidence
H2BC1	BAHD1	0.998	0.942	bioplex (H2BC1) bioplex_WMM
H2BC1	H2BC13	0.94	0.852	bioplex (H2BC1) bioplex_WMM
H2BC1	H2AFY2	0.077	0.354	bioplex (H2BC1) bioplex_WMM
H2BC1	H2AZ1	0.071	0.351	bioplex (H2BC1) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
H2BC13	H2AFY2	0.011	0.145	bioplex_WMM WMM_only
BAHD1	H2AFY2	0.008	0.085	bioplex_WMM WMM_only
BAHD1	H2BC13	0.008	0.084	bioplex_WMM WMM_only
H2AZ1	BAHD1	0.008	0.025	bioplex_WMM WMM_only
H2AZ1	H2AFY2	0.007	0.004	bioplex (H2AFY2) bioplex_WMM youn_WMM gupta_WMM
H2AZ1	H2BC13	0.007	0.007	bioplex_WMM WMM_only

Images

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Complex HuMAP2_02888 has an average edge precision of 0.285 which is ranked 4814 out of all 6965 complexes.

Related Complexes

Genename	Complexes
H2BC13	HuMAP2_00219 HuMAP2_01712 HuMAP2_02888 HuMAP2_05240 HuMAP2_05645 HuMAP2_06067 HuMAP2_06674
H2BC1	HuMAP2_00219 HuMAP2_01712 HuMAP2_02888 HuMAP2_05240 HuMAP2_06067 HuMAP2_06636 HuMAP2_06674
H2AZ1	HuMAP2_00219 HuMAP2_02888 HuMAP2_06067 HuMAP2_06636
H2AFY2	HuMAP2_02888 HuMAP2_05581
BAHD1	HuMAP2_00219 HuMAP2_01712 HuMAP2_02888 HuMAP2_05240 HuMAP2_06636 HuMAP2_06674

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02888