hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02896
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WLS | Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373) | UniProt NCBI |
| WNT4 | Protein Wnt-4 | UniProt NCBI |
| WNT5A | Protein Wnt-5a | UniProt NCBI |
| WNT7A | Protein Wnt-7a | UniProt NCBI |
| WNT7B | Protein Wnt-7b | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3238698 | 8.25299948055e-13 | 1.0 | WLS WNT7B WNT4 WNT7A WNT5A | WNT ligand biogenesis and trafficking |
| WP:WP4150 | 4.18349996586e-09 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Wnt Signaling in Kidney Disease |
| KEGG:05217 | 4.25486304909e-08 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Basal cell carcinoma |
| WP:WP4336 | 1.28370689553e-07 | 0.8 | WNT7A WNT7B WNT4 WNT5A | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| WP:WP4258 | 2.00221502161e-07 | 0.8 | WNT7A WNT7B WNT4 WNT5A | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| REAC:R-HSA-373080 | 2.03091825402e-07 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Class B/2 (Secretin family receptors) |
| KEGG:04916 | 2.82346737107e-07 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Melanogenesis |
| WP:WP399 | 3.11497655734e-07 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Wnt Signaling Pathway and Pluripotency |
| WP:WP3931 | 3.24735339401e-07 | 0.8 | WNT7A WNT7B WNT4 WNT5A | ESC Pluripotency Pathways |
| WP:WP710 | 4.13226609885e-07 | 0.8 | WNT7A WNT7B WNT4 WNT5A | DNA Damage Response (only ATM dependent) |
| WP:WP428 | 4.63701037706e-07 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Wnt Signaling |
| REAC:R-HSA-195721 | 5.66485895677e-07 | 1.0 | WLS WNT7B WNT4 WNT7A WNT5A | Signaling by WNT |
| KEGG:04550 | 1.04791543871e-06 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Signaling pathways regulating pluripotency of stem cells |
| GO:0030666 | 1.14985612896e-06 | 1.0 | WLS WNT7B WNT4 WNT7A WNT5A | endocytic vesicle membrane |
| WP:WP4239 | 1.18722341911e-06 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Epithelial to mesenchymal transition in colorectal cancer |
| KEGG:05224 | 1.31062068202e-06 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Breast cancer |
| WP:WP4262 | 1.33575765694e-06 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Breast cancer pathway |
| KEGG:05226 | 1.35182694454e-06 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Gastric cancer |
| KEGG:04934 | 1.81933554316e-06 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Cushing syndrome |
| KEGG:04390 | 1.87196857957e-06 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Hippo signaling pathway |
| KEGG:04150 | 1.98064768411e-06 | 0.8 | WNT7A WNT7B WNT4 WNT5A | mTOR signaling pathway |
| KEGG:04310 | 2.15244167448e-06 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Wnt signaling pathway |
| GO:0005109 | 2.89320355875e-06 | 0.8 | WNT7A WNT7B WNT4 WNT5A | frizzled binding |
| KEGG:05225 | 2.95343153553e-06 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Hepatocellular carcinoma |
| KEGG:05205 | 5.79761916632e-06 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Proteoglycans in cancer |
| REAC:R-HSA-500792 | 2.78971859313e-05 | 0.8 | WNT7A WNT7B WNT4 WNT5A | GPCR ligand binding |
| GO:0030139 | 2.92304744193e-05 | 1.0 | WLS WNT7B WNT4 WNT7A WNT5A | endocytic vesicle |
| KEGG:05165 | 4.42454478418e-05 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Human papillomavirus infection |
| GO:0060070 | 6.40365569743e-05 | 1.0 | WLS WNT7B WNT4 WNT7A WNT5A | canonical Wnt signaling pathway |
| GO:0005796 | 0.000173300430897 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Golgi lumen |
| KEGG:05200 | 0.000217862252065 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Pathways in cancer |
| GO:0016055 | 0.000424356792647 | 1.0 | WLS WNT7B WNT4 WNT7A WNT5A | Wnt signaling pathway |
| GO:0198738 | 0.000448326172357 | 1.0 | WLS WNT7B WNT4 WNT7A WNT5A | cell-cell signaling by wnt |
| GO:1905114 | 0.000639961088829 | 1.0 | WLS WNT7B WNT4 WNT7A WNT5A | cell surface receptor signaling pathway involved in cell-cell signaling |
| GO:0045165 | 0.000838244988417 | 0.8 | WNT7A WNT7B WNT4 WNT5A | cell fate commitment |
| REAC:R-HSA-3772470 | 0.00105126658749 | 0.4 | WNT4 WNT5A | Negative regulation of TCF-dependent signaling by WNT ligand antagonists |
| REAC:R-HSA-372790 | 0.0016972853423 | 0.8 | WNT7A WNT7B WNT4 WNT5A | Signaling by GPCR |
| GO:0030659 | 0.00192830724261 | 1.0 | WLS WNT7B WNT4 WNT7A WNT5A | cytoplasmic vesicle membrane |
| WP:WP2848 | 0.00197817058944 | 0.4 | WNT5A WNT7B | Differentiation Pathway |
| GO:0012506 | 0.00221997973486 | 1.0 | WLS WNT7B WNT4 WNT7A WNT5A | vesicle membrane |
| GO:0002088 | 0.00235581550516 | 0.6 | WNT7A WNT5A WNT7B | lens development in camera-type eye |
| GO:0001664 | 0.00238666327137 | 0.8 | WNT7A WNT7B WNT4 WNT5A | G protein-coupled receptor binding |
| HP:0000151 | 0.00422256197273 | 0.4 | WNT7A WNT4 | Aplasia of the uterus |
| GO:0044431 | 0.00522041133561 | 1.0 | WLS WNT7B WNT4 WNT7A WNT5A | Golgi apparatus part |
| REAC:R-HSA-162582 | 0.00595743543191 | 1.0 | WLS WNT7B WNT4 WNT7A WNT5A | Signal Transduction |
| GO:0003006 | 0.00749792730182 | 0.8 | WNT7A WNT7B WNT4 WNT5A | developmental process involved in reproduction |
| HP:0009811 | 0.00985583118217 | 0.6 | WNT7A WNT4 WNT5A | Abnormality of the elbow |
| GO:0048018 | 0.00986671964269 | 0.8 | WNT7A WNT7B WNT4 WNT5A | receptor ligand activity |
| GO:0030546 | 0.0106360428887 | 0.8 | WNT7A WNT7B WNT4 WNT5A | signaling receptor activator activity |
| GO:0030545 | 0.0134490676813 | 0.8 | WNT7A WNT7B WNT4 WNT5A | receptor regulator activity |
| GO:0045778 | 0.0146610377831 | 0.6 | WNT7B WNT4 WNT5A | positive regulation of ossification |
| GO:0005788 | 0.0165084833157 | 0.8 | WNT7A WNT7B WNT4 WNT5A | endoplasmic reticulum lumen |
| HP:0006262 | 0.0201414164419 | 0.4 | WNT7A WNT5A | Aplasia/Hypoplasia of the 5th finger |
| HP:0000047 | 0.0213196619429 | 0.6 | WNT7A WNT4 WNT5A | Hypospadias |
| HP:0000470 | 0.023494903838 | 0.6 | WNT7A WNT4 WNT5A | Short neck |
| HP:0032076 | 0.0249261794567 | 0.6 | WNT7A WNT4 WNT5A | Abnormal male urethral meatus morphology |
| HP:0100627 | 0.0249261794567 | 0.6 | WNT7A WNT4 WNT5A | Displacement of the urethral meatus |
| HP:0003319 | 0.0326006997834 | 0.6 | WNT7A WNT4 WNT5A | Abnormality of the cervical spine |
| HP:0000795 | 0.0396752856137 | 0.6 | WNT7A WNT4 WNT5A | Abnormality of the urethra |
| HP:0002937 | 0.0398018408038 | 0.4 | WNT7A WNT5A | Hemivertebrae |
| HP:0008684 | 0.0478196851342 | 0.4 | WNT7A WNT4 | Aplasia/hypoplasia of the uterus |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WNT4 | WNT7B | 0.998 | 0.941 | bioplex (WNT4) bioplex_WMM |
| WNT7A | WNT7B | 0.449 | 0.593 | bioplex (WNT7A) bioplex_WMM |
| WNT5A | WNT7A | 0.114 | 0.384 | bioplex (WNT7A) bioplex_WMM |
| WLS | WNT4 | 0.05 | 0.295 | bioplex (WNT4) bioplex_WMM |
| WLS | WNT7A | 0.018 | 0.177 | bioplex (WNT7A) bioplex_WMM |
| WNT4 | WNT5A | 0.016 | 0.161 | bioplex (WNT4) bioplex_WMM |
| WLS | WNT5A | 0.01 | 0.141 | bioplex (WNT5A) bioplex_WMM |
| WNT5A | WNT7B | 0.009 | 0.111 | bioplex_WMM WMM_only |
| WLS | WNT7B | 0.008 | 0.059 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02896 has an average edge precision of 0.318 which is ranked 4370 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| WLS | HuMAP2_02507 HuMAP2_02896 HuMAP2_03376 HuMAP2_06746 |
| WNT4 | HuMAP2_02896 HuMAP2_03376 HuMAP2_05188 HuMAP2_05720 |
| WNT5A | HuMAP2_02896 HuMAP2_05252 |
| WNT7A | HuMAP2_02896 HuMAP2_03376 HuMAP2_04106 HuMAP2_05720 |
| WNT7B | HuMAP2_02896 HuMAP2_03376 HuMAP2_05188 HuMAP2_05720 |