hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02908

Confidence: Medium

Genename	Protein Name	Links
PDHA2	Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II)	UniProt NCBI
PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)	UniProt NCBI
PDK2	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)	UniProt NCBI
PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)	UniProt NCBI
PDK4	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4)	UniProt NCBI
SYT12	Synaptotagmin-12 (Synaptotagmin XII) (SytXII)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-204174	7.03481530925e-13	0.833333333333	PDK4 PDHA2 PDK3 PDK2 PDK1	Regulation of pyruvate dehydrogenase (PDH) complex
REAC:R-HSA-70268	1.91119794167e-11	0.833333333333	PDK4 PDHA2 PDK3 PDK2 PDK1	Pyruvate metabolism
REAC:R-HSA-5362517	1.0583202737e-10	0.833333333333	PDK4 PDHA2 PDK3 PDK2 PDK1	Signaling by Retinoic Acid
GO:0004740	3.6593342028e-10	0.666666666667	PDK4 PDK1 PDK2 PDK3	pyruvate dehydrogenase (acetyl-transferring) kinase activity
REAC:R-HSA-71406	4.17727607273e-10	0.833333333333	PDK4 PDHA2 PDK3 PDK2 PDK1	Pyruvate metabolism and Citric Acid (TCA) cycle
GO:0050812	2.56043303928e-08	0.666666666667	PDK4 PDK1 PDK2 PDK3	regulation of acyl-CoA biosynthetic process
GO:0010510	2.56043303928e-08	0.666666666667	PDK4 PDK1 PDK2 PDK3	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0042762	7.67964804112e-08	0.666666666667	PDK4 PDK1 PDK2 PDK3	regulation of sulfur metabolic process
GO:0051196	7.67964804112e-08	0.666666666667	PDK4 PDK1 PDK2 PDK3	regulation of coenzyme metabolic process
REAC:R-HSA-1428517	1.53110819373e-07	0.833333333333	PDK4 PDHA2 PDK3 PDK2 PDK1	The citric acid (TCA) cycle and respiratory electron transport
GO:0006086	1.80981361376e-07	0.666666666667	PDK4 PDK1 PDK2 PDK3	acetyl-CoA biosynthetic process from pyruvate
GO:0006085	8.69705349223e-07	0.666666666667	PDK4 PDK1 PDK2 PDK3	acetyl-CoA biosynthetic process
REAC:R-HSA-9006931	1.09963201659e-06	0.833333333333	PDK4 PDHA2 PDK3 PDK2 PDK1	Signaling by Nuclear Receptors
GO:0051193	2.18611257075e-06	0.666666666667	PDK4 PDK1 PDK2 PDK3	regulation of cofactor metabolic process
GO:1900371	2.67162800295e-06	0.666666666667	PDK4 PDK1 PDK2 PDK3	regulation of purine nucleotide biosynthetic process
GO:0030808	3.23372816466e-06	0.666666666667	PDK4 PDK1 PDK2 PDK3	regulation of nucleotide biosynthetic process
GO:0006084	5.45777947309e-06	0.666666666667	PDK4 PDK1 PDK2 PDK3	acetyl-CoA metabolic process
GO:0006090	1.1450156336e-05	0.833333333333	PDK4 PDHA2 PDK3 PDK2 PDK1	pyruvate metabolic process
GO:0035384	4.07918542432e-05	0.666666666667	PDK4 PDK1 PDK2 PDK3	thioester biosynthetic process
GO:0071616	4.07918542432e-05	0.666666666667	PDK4 PDK1 PDK2 PDK3	acyl-CoA biosynthetic process
GO:0019217	0.000133653758006	0.666666666667	PDK4 PDK1 PDK2 PDK3	regulation of fatty acid metabolic process
GO:0034030	0.000133653758006	0.666666666667	PDK4 PDK1 PDK2 PDK3	ribonucleoside bisphosphate biosynthetic process
GO:0033866	0.000133653758006	0.666666666667	PDK4 PDK1 PDK2 PDK3	nucleoside bisphosphate biosynthetic process
GO:0034033	0.000133653758006	0.666666666667	PDK4 PDK1 PDK2 PDK3	purine nucleoside bisphosphate biosynthetic process
GO:0010906	0.000202863918666	0.666666666667	PDK4 PDK1 PDK2 PDK3	regulation of glucose metabolic process
GO:0010675	0.000517834485544	0.666666666667	PDK4 PDK1 PDK2 PDK3	regulation of cellular carbohydrate metabolic process
GO:0006637	0.000574036481079	0.666666666667	PDK4 PDK1 PDK2 PDK3	acyl-CoA metabolic process
GO:0035383	0.000574036481079	0.666666666667	PDK4 PDK1 PDK2 PDK3	thioester metabolic process
GO:1900542	0.000770248195723	0.666666666667	PDK4 PDK1 PDK2 PDK3	regulation of purine nucleotide metabolic process
GO:0006140	0.00084563217517	0.666666666667	PDK4 PDK1 PDK2 PDK3	regulation of nucleotide metabolic process
WP:WP4206	0.00105843860426	0.333333333333	PDHA2 PDK1	Hereditary leiomyomatosis and renal cell carcinoma pathway
GO:0033865	0.00208860909913	0.666666666667	PDK4 PDK1 PDK2 PDK3	nucleoside bisphosphate metabolic process
GO:0033875	0.00208860909913	0.666666666667	PDK4 PDK1 PDK2 PDK3	ribonucleoside bisphosphate metabolic process
GO:0034032	0.00208860909913	0.666666666667	PDK4 PDK1 PDK2 PDK3	purine nucleoside bisphosphate metabolic process
GO:0009108	0.00258873731728	0.666666666667	PDK4 PDK1 PDK2 PDK3	coenzyme biosynthetic process
GO:0009152	0.00317351526138	0.666666666667	PDK4 PDK1 PDK2 PDK3	purine ribonucleotide biosynthetic process
GO:0006006	0.00327983341783	0.666666666667	PDK4 PDK1 PDK2 PDK3	glucose metabolic process
GO:0009260	0.00397477358415	0.666666666667	PDK4 PDK1 PDK2 PDK3	ribonucleotide biosynthetic process
GO:0010565	0.00436089686659	0.666666666667	PDK4 PDK1 PDK2 PDK3	regulation of cellular ketone metabolic process
GO:0005759	0.00447076835271	0.833333333333	PDK4 PDHA2 PDK3 PDK2 PDK1	mitochondrial matrix
GO:0006164	0.00477442110408	0.666666666667	PDK4 PDK1 PDK2 PDK3	purine nucleotide biosynthetic process
GO:0046390	0.00477442110408	0.666666666667	PDK4 PDK1 PDK2 PDK3	ribose phosphate biosynthetic process
GO:0006109	0.00477442110408	0.666666666667	PDK4 PDK1 PDK2 PDK3	regulation of carbohydrate metabolic process
GO:0072522	0.0065457435483	0.666666666667	PDK4 PDK1 PDK2 PDK3	purine-containing compound biosynthetic process
GO:0019318	0.00790339487449	0.666666666667	PDK4 PDK1 PDK2 PDK3	hexose metabolic process
GO:0044272	0.00832729271377	0.666666666667	PDK4 PDK1 PDK2 PDK3	sulfur compound biosynthetic process
GO:0032787	0.00974381439214	0.833333333333	PDK4 PDHA2 PDK3 PDK2 PDK1	monocarboxylic acid metabolic process
GO:0044262	0.0104487739309	0.666666666667	PDK4 PDK1 PDK2 PDK3	cellular carbohydrate metabolic process
KEGG:05230	0.013683677248	0.333333333333	PDHA2 PDK1	Central carbon metabolism in cancer
GO:0042180	0.0138763169989	0.666666666667	PDK4 PDK1 PDK2 PDK3	cellular ketone metabolic process
GO:0051188	0.0148506630994	0.666666666667	PDK4 PDK1 PDK2 PDK3	cofactor biosynthetic process
GO:0009165	0.0151865312966	0.666666666667	PDK4 PDK1 PDK2 PDK3	nucleotide biosynthetic process
GO:0005996	0.0173225074522	0.666666666667	PDK4 PDK1 PDK2 PDK3	monosaccharide metabolic process
GO:1901293	0.0180820254396	0.666666666667	PDK4 PDK1 PDK2 PDK3	nucleoside phosphate biosynthetic process
GO:0097411	0.020283420769	0.333333333333	PDK1 PDK3	hypoxia-inducible factor-1alpha signaling pathway
GO:0006732	0.0222594167129	0.666666666667	PDK4 PDK1 PDK2 PDK3	coenzyme metabolic process
REAC:R-HSA-1430728	0.0278608311428	0.833333333333	PDK4 PDHA2 PDK3 PDK2 PDK1	Metabolism
KEGG:04066	0.0304541793376	0.333333333333	PDHA2 PDK1	HIF-1 signaling pathway
REAC:R-HSA-162582	0.0348492364063	0.833333333333	PDK4 PDHA2 PDK3 PDK2 PDK1	Signal Transduction

Edges

Protein 1	Protein 2	Score	Precision	Evidence
PDHA2	PDK3	1.0	0.949	bioplex (PDK3) bioplex_WMM
PDK1	PDK2	1.0	0.949	hein_WMM bioplex (PDK1) bioplex_WMM hein (PDK1)
PDK3	PDK1	1.0	0.949	hein_WMM bioplex (PDK1,PDK3) bioplex_WMM youn_WMM hein (PDK1)
PDK3	PDK2	0.444	0.588	hein_WMM bioplex (PDK3) bioplex_WMM
PDK2	PDK4	0.128	0.399	bioplex (PDK4) bioplex_WMM
PDK2	SYT12	0.03	0.234	bioplex (SYT12) bioplex_WMM
PDK3	PDK4	0.027	0.228	bioplex (PDK4) bioplex_WMM
PDK1	PDK4	0.022	0.205	bioplex (PDK4) bioplex_WMM
PDK3	SYT12	0.011	0.134	bioplex (SYT12) bioplex_WMM
PDHA2	PDK2	0.008	0.037	bioplex_WMM WMM_only
PDHA2	PDK1	0.008	0.027	bioplex_WMM WMM_only

Images

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Complex HuMAP2_02908 has an average edge precision of 0.427 which is ranked 3048 out of all 6965 complexes.

Related Complexes

Genename	Complexes
PDHA2	HuMAP2_00749 HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_06120 HuMAP2_06177
PDK1	HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_03608
PDK2	HuMAP2_01188 HuMAP2_02908 HuMAP2_03608
PDK3	HuMAP2_00749 HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_06086
PDK4	HuMAP2_01188 HuMAP2_02908
SYT12	HuMAP2_02908 HuMAP2_06053

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02908