hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02912
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CACYBP | Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein) | UniProt NCBI |
| FKBP4 | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | UniProt NCBI |
| CDV3 | Protein CDV3 homolog | UniProt NCBI |
| EZR | Ezrin (Cytovillin) (Villin-2) (p81) | UniProt NCBI |
| YTHDF1 | YTH domain-containing family protein 1 (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) | UniProt NCBI |
| TPD52L2 | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | UniProt NCBI |
| MSN | Moesin (Membrane-organizing extension spike protein) | UniProt NCBI |
| ACAA2 | 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-) (EC 3.1.2.1) (EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1) | UniProt NCBI |
| RDX | Radixin | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1902965 | 0.000152436922042 | 0.333333333333 | MSN RDX EZR | regulation of protein localization to early endosome |
| GO:1902966 | 0.000152436922042 | 0.333333333333 | MSN RDX EZR | positive regulation of protein localization to early endosome |
| GO:1905668 | 0.000152436922042 | 0.333333333333 | MSN RDX EZR | positive regulation of protein localization to endosome |
| GO:1905666 | 0.000266683990267 | 0.333333333333 | MSN RDX EZR | regulation of protein localization to endosome |
| REAC:R-HSA-437239 | 0.000425839414749 | 0.333333333333 | MSN RDX EZR | Recycling pathway of L1 |
| GO:2000643 | 0.000426565421795 | 0.333333333333 | MSN RDX EZR | positive regulation of early endosome to late endosome transport |
| GO:1902946 | 0.00063965474072 | 0.333333333333 | MSN RDX EZR | protein localization to early endosome |
| GO:1903651 | 0.00167376753379 | 0.333333333333 | MSN RDX EZR | positive regulation of cytoplasmic transport |
| WP:WP51 | 0.00329181710615 | 0.333333333333 | MSN RDX EZR | Regulation of Actin Cytoskeleton |
| KEGG:04530 | 0.00372212913023 | 0.333333333333 | MSN RDX EZR | Tight junction |
| GO:2000641 | 0.00619690362803 | 0.333333333333 | MSN RDX EZR | regulation of early endosome to late endosome transport |
| REAC:R-HSA-373760 | 0.00652483358031 | 0.333333333333 | MSN RDX EZR | L1CAM interactions |
| GO:0036010 | 0.00735659813211 | 0.333333333333 | MSN RDX EZR | protein localization to endosome |
| KEGG:04810 | 0.0079196896968 | 0.333333333333 | MSN RDX EZR | Regulation of actin cytoskeleton |
| KEGG:05205 | 0.0080456699999 | 0.333333333333 | MSN RDX EZR | Proteoglycans in cancer |
| GO:1903649 | 0.0134290861763 | 0.333333333333 | MSN RDX EZR | regulation of cytoplasmic transport |
| WP:WP2324 | 0.0396376262126 | 0.222222222222 | MSN EZR | AGE/RAGE pathway |
| GO:0061028 | 0.045224564378 | 0.333333333333 | MSN RDX EZR | establishment of endothelial barrier |
| CORUM:6784 | 0.0499262710315 | 0.111111111111 | EZR | SCHIP1-EZR-NHERF2 complex |
| CORUM:6791 | 0.0499262710315 | 0.111111111111 | EZR | NHERF1-NPT2A-EZR complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TPD52L2 | EZR | 0.999 | 0.946 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| EZR | RDX | 0.989 | 0.906 | hein_WMM bioplex_WMM youn_WMM hein (EZR) gupta_WMM treiber_WMM |
| MSN | EZR | 0.965 | 0.874 | hein_WMM bioplex_WMM hein (EZR,MSN) gupta_WMM treiber_WMM |
| CACYBP | MSN | 0.961 | 0.869 | bioplex_WMM Guru gupta_WMM fraction |
| CACYBP | EZR | 0.901 | 0.826 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| CDV3 | MSN | 0.891 | 0.818 | bioplex_WMM gupta_WMM fraction |
| MSN | RDX | 0.89 | 0.818 | hein_WMM bioplex_WMM hein (MSN) treiber_WMM |
| EZR | ACAA2 | 0.748 | 0.742 | bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| ACAA2 | RDX | 0.744 | 0.74 | bioplex_WMM Guru gupta_WMM fraction |
| MSN | ACAA2 | 0.468 | 0.604 | bioplex_WMM Guru fraction |
| FKBP4 | MSN | 0.414 | 0.571 | bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| CACYBP | RDX | 0.293 | 0.494 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| FKBP4 | CDV3 | 0.199 | 0.452 | bioplex_WMM youn_WMM gupta_WMM fraction |
| CACYBP | FKBP4 | 0.162 | 0.419 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| CACYBP | TPD52L2 | 0.15 | 0.41 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| TPD52L2 | MSN | 0.124 | 0.395 | bioplex_WMM Guru gupta_WMM fraction |
| FKBP4 | TPD52L2 | 0.107 | 0.373 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| TPD52L2 | RDX | 0.107 | 0.373 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| YTHDF1 | MSN | 0.064 | 0.349 | gupta_WMM fraction |
| FKBP4 | EZR | 0.037 | 0.268 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| CACYBP | CDV3 | 0.02 | 0.187 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| YTHDF1 | EZR | 0.012 | 0.149 | bioplex_WMM youn_WMM gupta_WMM fraction |
| CDV3 | RDX | 0.008 | 0.016 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CDV3 | YTHDF1 | 0.007 | 0.011 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CDV3 | EZR | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| YTHDF1 | RDX | 0.006 | 0.001 | youn_WMM gupta_WMM fraction |
| CACYBP | ACAA2 | 0.006 | 0.012 | bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| CACYBP | YTHDF1 | 0.005 | 0.01 | bioplex_WMM youn_WMM gupta_WMM fraction |
| FKBP4 | RDX | 0.004 | 0.007 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| CDV3 | ACAA2 | 0.003 | 0.021 | bioplex_WMM WMM_only |
| FKBP4 | YTHDF1 | 0.0 | 0.015 | youn_WMM gupta_WMM fraction |
| YTHDF1 | TPD52L2 | 0.0 | 0.015 | youn_WMM gupta_WMM fraction |
| CDV3 | TPD52L2 | 0.0 | 0.01 | bioplex_WMM youn_WMM gupta_WMM fraction |
| TPD52L2 | ACAA2 | 0.0 | 0.002 | bioplex_WMM Guru gupta_WMM fraction |
| YTHDF1 | ACAA2 | 0.0 | 0.0 | fraction |
| FKBP4 | ACAA2 | 0.0 | 0.0 | bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_02912 has an average edge precision of 0.353 which is ranked 3888 out of all 6965 complexes.
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