hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02924

Confidence: Medium

Genename	Protein Name	Links
PNISR	Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18)	UniProt NCBI
CHD9	Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.12) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein)	UniProt NCBI
HDGFL2	Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)	UniProt NCBI
GPALPP1	GPALPP motifs-containing protein 1 (Lipopolysaccharide-specific response protein 7)	UniProt NCBI
MEX3C	RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C)	UniProt NCBI
STRADA	STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96)	UniProt NCBI
GRM3	Metabotropic glutamate receptor 3 (mGluR3)	UniProt NCBI
NHP2	H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2)	UniProt NCBI
PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)	UniProt NCBI
DIP2C	Disco-interacting protein 2 homolog C (DIP2 homolog C)	UniProt NCBI
PIP4K2B	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)	UniProt NCBI
AFF3	AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4)	UniProt NCBI
RFWD3	E3 ubiquitin-protein ligase RFWD3 (EC 2.3.2.27) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201)	UniProt NCBI
PIP4K2C	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)	UniProt NCBI
PPRC1	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8847453	8.88117787841e-07	0.2	PIP4K2C PIP4K2B PIP4K2A	Synthesis of PIPs in the nucleus
REAC:R-HSA-6811555	1.85941783968e-05	0.2	PIP4K2C PIP4K2B PIP4K2A	PI5P Regulates TP53 Acetylation
REAC:R-HSA-6804758	0.000887378157037	0.2	PIP4K2C PIP4K2B PIP4K2A	Regulation of TP53 Activity through Acetylation
GO:2000786	0.0023070725905	0.2	PIP4K2C PIP4K2B PIP4K2A	positive regulation of autophagosome assembly
KEGG:00562	0.00242159923647	0.2	PIP4K2C PIP4K2B PIP4K2A	Inositol phosphate metabolism
REAC:R-HSA-1660499	0.0037393835852	0.2	PIP4K2C PIP4K2B PIP4K2A	Synthesis of PIPs at the plasma membrane
KEGG:04070	0.00525350435581	0.2	PIP4K2C PIP4K2B PIP4K2A	Phosphatidylinositol signaling system
GO:0044090	0.00678530576901	0.2	PIP4K2C PIP4K2B PIP4K2A	positive regulation of vacuole organization
REAC:R-HSA-6811558	0.0111845389248	0.2	PIP4K2C PIP4K2B PIP4K2A	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
REAC:R-HSA-199418	0.0149434975051	0.2	PIP4K2C PIP4K2B PIP4K2A	Negative regulation of the PI3K/AKT network
MIRNA:hsa-miR-6881-3p	0.0158941961396	0.266666666667	RFWD3 DIP2C PIP4K2B AFF3	hsa-miR-6881-3p
REAC:R-HSA-1483255	0.0161517271852	0.2	PIP4K2C PIP4K2B PIP4K2A	PI Metabolism
WP:WP51	0.0198055237669	0.2	PIP4K2C PIP4K2B PIP4K2A	Regulation of Actin Cytoskeleton
KEGG:04810	0.0423562150582	0.2	PIP4K2C PIP4K2B PIP4K2A	Regulation of actin cytoskeleton
CORUM:6370	0.0498572752401	0.0666666666667	GRM3	mGluR3-mGluR7 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
PIP4K2A	PIP4K2C	1.0	0.949	hein_WMM bioplex (PIP4K2A) bioplex_WMM boldt youn_WMM hein (PIP4K2C) gupta_WMM boldt_WMM
PIP4K2B	PIP4K2A	0.999	0.949	hein_WMM bioplex (PIP4K2A) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
DIP2C	PIP4K2A	0.61	0.674	bioplex (PIP4K2A) bioplex_WMM
GRM3	PIP4K2A	0.52	0.633	bioplex (PIP4K2A) bioplex_WMM
PIP4K2B	PIP4K2C	0.392	0.554	hein_WMM bioplex_WMM boldt youn_WMM hein (PIP4K2C) gupta_WMM boldt_WMM
PIP4K2A	HDGFL2	0.362	0.543	bioplex (PIP4K2A) bioplex_WMM youn_WMM gupta_WMM
PIP4K2A	MEX3C	0.316	0.51	bioplex (PIP4K2A) bioplex_WMM
PIP4K2A	AFF3	0.316	0.51	bioplex (PIP4K2A) bioplex_WMM
PIP4K2A	PNISR	0.161	0.417	bioplex (PIP4K2A) bioplex_WMM youn_WMM gupta_WMM
GPALPP1	PIP4K2A	0.091	0.354	bioplex (PIP4K2A) bioplex_WMM youn_WMM gupta_WMM fraction
STRADA	PIP4K2A	0.042	0.27	bioplex (PIP4K2A) bioplex_WMM
PIP4K2A	PPRC1	0.033	0.25	bioplex (PIP4K2A) bioplex_WMM
PIP4K2A	CHD9	0.024	0.213	bioplex (PIP4K2A) bioplex_WMM
NHP2	PIP4K2C	0.021	0.194	youn_WMM fraction
PIP4K2A	RFWD3	0.021	0.189	bioplex (PIP4K2A) bioplex_WMM
PNISR	CHD9	0.009	0.104	hein_WMM bioplex_WMM youn_WMM WMM_only
DIP2C	GRM3	0.009	0.095	bioplex_WMM WMM_only
PNISR	PIP4K2C	0.009	0.095	bioplex_WMM youn_WMM gupta_WMM WMM_only
DIP2C	MEX3C	0.008	0.091	bioplex_WMM WMM_only
DIP2C	PNISR	0.008	0.091	bioplex_WMM WMM_only
DIP2C	AFF3	0.008	0.091	bioplex_WMM WMM_only
GRM3	AFF3	0.008	0.091	bioplex_WMM WMM_only
DIP2C	PPRC1	0.008	0.091	bioplex_WMM WMM_only
GRM3	PNISR	0.008	0.091	bioplex_WMM WMM_only
GRM3	MEX3C	0.008	0.091	bioplex_WMM WMM_only
GRM3	PPRC1	0.008	0.091	bioplex_WMM WMM_only
PIP4K2B	DIP2C	0.008	0.085	bioplex_WMM WMM_only
PIP4K2B	GRM3	0.008	0.085	bioplex_WMM WMM_only
PNISR	PPRC1	0.008	0.085	bioplex_WMM WMM_only
PNISR	AFF3	0.008	0.085	bioplex_WMM WMM_only
PPRC1	MEX3C	0.008	0.085	bioplex_WMM WMM_only
AFF3	PPRC1	0.008	0.085	bioplex_WMM WMM_only
AFF3	MEX3C	0.008	0.085	bioplex_WMM WMM_only
PNISR	MEX3C	0.008	0.085	bioplex_WMM WMM_only
GRM3	CHD9	0.008	0.082	bioplex_WMM WMM_only
DIP2C	CHD9	0.008	0.082	bioplex_WMM WMM_only
PIP4K2B	PNISR	0.008	0.081	bioplex_WMM youn_WMM gupta_WMM WMM_only
GPALPP1	PNISR	0.008	0.072	bioplex_WMM youn_WMM gupta_WMM WMM_only
STRADA	GRM3	0.008	0.067	bioplex_WMM WMM_only
STRADA	DIP2C	0.008	0.067	bioplex_WMM WMM_only
PNISR	HDGFL2	0.008	0.069	bioplex_WMM youn_WMM gupta_WMM WMM_only
PIP4K2B	MEX3C	0.008	0.062	bioplex_WMM WMM_only
PIP4K2B	AFF3	0.008	0.062	bioplex_WMM WMM_only
PIP4K2B	PPRC1	0.008	0.062	bioplex_WMM WMM_only
DIP2C	RFWD3	0.008	0.06	bioplex_WMM WMM_only
GRM3	RFWD3	0.008	0.06	bioplex_WMM WMM_only
CHD9	MEX3C	0.008	0.046	bioplex_WMM WMM_only
AFF3	CHD9	0.008	0.046	bioplex_WMM WMM_only
PIP4K2C	CHD9	0.008	0.041	bioplex_WMM youn_WMM WMM_only
STRADA	AFF3	0.008	0.04	bioplex_WMM WMM_only
STRADA	PNISR	0.008	0.04	bioplex_WMM WMM_only
STRADA	MEX3C	0.008	0.04	bioplex_WMM WMM_only
STRADA	PPRC1	0.008	0.04	bioplex_WMM WMM_only
GPALPP1	PIP4K2B	0.008	0.03	bioplex_WMM youn_WMM gupta_WMM WMM_only
GRM3	PIP4K2C	0.008	0.029	bioplex_WMM WMM_only
DIP2C	PIP4K2C	0.008	0.029	bioplex_WMM WMM_only
GPALPP1	DIP2C	0.008	0.026	bioplex_WMM WMM_only
GPALPP1	GRM3	0.008	0.026	bioplex_WMM WMM_only
PNISR	RFWD3	0.008	0.025	bioplex_WMM WMM_only
RFWD3	PPRC1	0.008	0.025	bioplex_WMM WMM_only
RFWD3	MEX3C	0.008	0.025	bioplex_WMM WMM_only
AFF3	RFWD3	0.008	0.025	bioplex_WMM WMM_only
PIP4K2B	CHD9	0.008	0.028	bioplex_WMM WMM_only
DIP2C	HDGFL2	0.008	0.027	bioplex_WMM WMM_only
GRM3	HDGFL2	0.008	0.027	bioplex_WMM WMM_only
PPRC1	CHD9	0.008	0.019	hein_WMM bioplex_WMM WMM_only
STRADA	PIP4K2B	0.008	0.016	bioplex_WMM WMM_only
GPALPP1	PIP4K2C	0.008	0.01	bioplex_WMM youn_WMM gupta_WMM WMM_only
PIP4K2C	PPRC1	0.007	0.01	bioplex_WMM WMM_only
PIP4K2C	MEX3C	0.007	0.01	bioplex_WMM WMM_only
AFF3	PIP4K2C	0.007	0.01	bioplex_WMM WMM_only
STRADA	CHD9	0.007	0.01	bioplex_WMM WMM_only
GPALPP1	MEX3C	0.007	0.007	bioplex_WMM WMM_only
GPALPP1	AFF3	0.007	0.007	bioplex_WMM WMM_only
GPALPP1	PPRC1	0.007	0.007	bioplex_WMM WMM_only
PIP4K2B	RFWD3	0.007	0.006	bioplex_WMM WMM_only
AFF3	HDGFL2	0.007	0.008	bioplex_WMM WMM_only
HDGFL2	MEX3C	0.007	0.008	bioplex_WMM WMM_only
PPRC1	HDGFL2	0.007	0.008	bioplex_WMM WMM_only
RFWD3	CHD9	0.007	0.009	bioplex_WMM WMM_only
GPALPP1	HDGFL2	0.007	0.009	bioplex_WMM youn_WMM gupta_WMM WMM_only
STRADA	RFWD3	0.007	0.004	bioplex_WMM WMM_only
PIP4K2B	HDGFL2	0.007	0.007	bioplex_WMM youn_WMM gupta_WMM WMM_only
GPALPP1	CHD9	0.007	0.005	bioplex_WMM youn_WMM WMM_only
STRADA	PIP4K2C	0.007	0.003	bioplex_WMM WMM_only
HDGFL2	CHD9	0.007	0.0	bioplex_WMM youn_WMM WMM_only
STRADA	GPALPP1	0.007	0.006	bioplex_WMM WMM_only
STRADA	HDGFL2	0.007	0.0	bioplex_WMM WMM_only
RFWD3	PIP4K2C	0.007	0.002	bioplex_WMM WMM_only
GPALPP1	RFWD3	0.007	0.001	bioplex_WMM WMM_only
NHP2	GPALPP1	0.007	0.002	youn_WMM WMM_only
NHP2	HDGFL2	0.007	0.003	youn_WMM WMM_only
NHP2	PNISR	0.007	0.001	youn_WMM WMM_only
RFWD3	HDGFL2	0.007	0.005	bioplex_WMM WMM_only
PIP4K2C	HDGFL2	0.007	0.003	bioplex_WMM youn_WMM gupta_WMM WMM_only

Images

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Complex HuMAP2_02924 has an average edge precision of 0.111 which is ranked 6907 out of all 6965 complexes.

Related Complexes

Genename	Complexes
PNISR	HuMAP2_02924 HuMAP2_06218 HuMAP2_06806
CHD9	HuMAP2_02924 HuMAP2_03761 HuMAP2_04112
HDGFL2	HuMAP2_02924 HuMAP2_05709
GPALPP1	HuMAP2_01410 HuMAP2_02590 HuMAP2_02924 HuMAP2_06325 HuMAP2_06977
MEX3C	HuMAP2_02924 HuMAP2_06931
STRADA	HuMAP2_00480 HuMAP2_01236 HuMAP2_02924 HuMAP2_03685 HuMAP2_03829 HuMAP2_04879 HuMAP2_05382 HuMAP2_06034 HuMAP2_06078 HuMAP2_06088
GRM3	HuMAP2_02924
NHP2	HuMAP2_00762 HuMAP2_02643 HuMAP2_02924 HuMAP2_04574
PIP4K2A	HuMAP2_02924 HuMAP2_03783 HuMAP2_06570
DIP2C	HuMAP2_02924
PIP4K2B	HuMAP2_01753 HuMAP2_02385 HuMAP2_02924 HuMAP2_03783 HuMAP2_04594 HuMAP2_06570
AFF3	HuMAP2_02924 HuMAP2_04784 HuMAP2_04903
RFWD3	HuMAP2_02924 HuMAP2_05878
PIP4K2C	HuMAP2_02924 HuMAP2_03783 HuMAP2_04594 HuMAP2_06570
PPRC1	HuMAP2_02924 HuMAP2_03597 HuMAP2_04905 HuMAP2_05911

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02924