hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02943
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CTNNB1 | Catenin beta-1 (Beta-catenin) | UniProt NCBI |
| CTNNA1 | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | UniProt NCBI |
| CDH10 | Cadherin-10 (T2-cadherin) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-418990 | 1.31507096469e-06 | 1.0 | CTNNA1 CTNNB1 CDH10 | Adherens junctions interactions |
| CORUM:4096 | 3.35600554376e-06 | 0.666666666667 | CTNNA1 CTNNB1 | CTNNA1-CTNNB1 complex |
| REAC:R-HSA-421270 | 5.95446148936e-06 | 1.0 | CTNNA1 CTNNB1 CDH10 | Cell-cell junction organization |
| WP:WP4541 | 1.10592549668e-05 | 1.0 | CTNNA1 CTNNB1 CDH10 | Hippo-Merlin Signaling Dysregulation |
| REAC:R-HSA-446728 | 2.56967114485e-05 | 1.0 | CTNNA1 CTNNB1 CDH10 | Cell junction organization |
| REAC:R-HSA-1500931 | 7.95116633082e-05 | 1.0 | CTNNA1 CTNNB1 CDH10 | Cell-Cell communication |
| GO:0016342 | 0.000139860607076 | 1.0 | CTNNA1 CTNNB1 CDH10 | catenin complex |
| KEGG:05213 | 0.00071298933464 | 0.666666666667 | CTNNA1 CTNNB1 | Endometrial cancer |
| WP:WP4534 | 0.000785169744646 | 0.666666666667 | CTNNA1 CTNNB1 | Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms |
| KEGG:04520 | 0.00104747631534 | 0.666666666667 | CTNNA1 CTNNB1 | Adherens junction |
| KEGG:05412 | 0.0011410864499 | 0.666666666667 | CTNNA1 CTNNB1 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| KEGG:05100 | 0.00117317704338 | 0.666666666667 | CTNNA1 CTNNB1 | Bacterial invasion of epithelial cells |
| KEGG:04670 | 0.0017077231529 | 0.666666666667 | CTNNA1 CTNNB1 | Leukocyte transendothelial migration |
| WP:WP4155 | 0.0018089728338 | 0.666666666667 | CTNNA1 CTNNB1 | Endometrial cancer |
| REAC:R-HSA-525793 | 0.00200655101382 | 0.666666666667 | CTNNA1 CTNNB1 | Myogenesis |
| REAC:R-HSA-5218920 | 0.00217366618564 | 0.666666666667 | CTNNA1 CTNNB1 | VEGFR2 mediated vascular permeability |
| WP:WP2118 | 0.00224353083145 | 0.666666666667 | CTNNA1 CTNNB1 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| REAC:R-HSA-5626467 | 0.00252791438215 | 0.666666666667 | CTNNA1 CTNNB1 | RHO GTPases activate IQGAPs |
| WP:WP4540 | 0.00357470816736 | 0.666666666667 | CDH10 CTNNB1 | Pathways Regulating Hippo Signaling |
| KEGG:05226 | 0.00379131738697 | 0.666666666667 | CTNNA1 CTNNB1 | Gastric cancer |
| KEGG:04390 | 0.00445520604942 | 0.666666666667 | CTNNA1 CTNNB1 | Hippo signaling pathway |
| GO:0071681 | 0.0135228859698 | 0.666666666667 | CTNNA1 CTNNB1 | cellular response to indole-3-methanol |
| GO:0071680 | 0.0135228859698 | 0.666666666667 | CTNNA1 CTNNB1 | response to indole-3-methanol |
| GO:0034332 | 0.0185411572066 | 1.0 | CTNNA1 CTNNB1 CDH10 | adherens junction organization |
| WP:WP3888 | 0.0226746026379 | 0.666666666667 | CTNNA1 CTNNB1 | VEGFA-VEGFR2 Signaling Pathway |
| CORUM:6680 | 0.0249904952816 | 0.333333333333 | CTNNB1 | CTNNB1-GLIS2 complex |
| REAC:R-HSA-4420097 | 0.0273084129672 | 0.666666666667 | CTNNA1 CTNNB1 | VEGFA-VEGFR2 Pathway |
| GO:0019897 | 0.0281650200706 | 1.0 | CTNNA1 CTNNB1 CDH10 | extrinsic component of plasma membrane |
| REAC:R-HSA-194138 | 0.0323383341591 | 0.666666666667 | CTNNA1 CTNNB1 | Signaling by VEGF |
| KEGG:05200 | 0.0473113658041 | 0.666666666667 | CTNNA1 CTNNB1 | Pathways in cancer |
| CORUM:6336 | 0.0499776345577 | 0.333333333333 | CTNNB1 | CTNNB1-DNMT1 complex |
| CORUM:6339 | 0.0499776345577 | 0.333333333333 | CTNNB1 | beta-catenin-B-cell lymphoma 9 protein complex |
| CORUM:6359 | 0.0499776345577 | 0.333333333333 | CTNNB1 | RHAMM-beta-catenin complex |
| CORUM:6364 | 0.0499776345577 | 0.333333333333 | CTNNB1 | OVOL2-beta-catenin-TCF4 complex |
| CORUM:5281 | 0.0499776345577 | 0.333333333333 | CTNNB1 | Cell-cell junction complex (CDH1-CTNNB1) |
| CORUM:6961 | 0.0499776345577 | 0.333333333333 | CTNNB1 | CTNNB1-GID8 complex |
| CORUM:7312 | 0.0499776345577 | 0.333333333333 | CTNNB1 | CTNNB1-ESR1 complex |
| CORUM:5274 | 0.0499776345577 | 0.333333333333 | CTNNA1 | Cell-cell junction complex (ARHGAP10-CTNNA1) |
| CORUM:5262 | 0.0499776345577 | 0.333333333333 | CTNNB1 | TCF4-CTNNB1 complex |
| CORUM:4095 | 0.0499776345577 | 0.333333333333 | CTNNB1 | CTNNAL1-CTNNB1 complex |
| CORUM:3155 | 0.0499776345577 | 0.333333333333 | CTNNB1 | TFC4-CTNNB1 complex |
| CORUM:6269 | 0.0499776345577 | 0.333333333333 | CTNNB1 | DLL1-CTNNB1-CDH2 complex |
| CORUM:6334 | 0.0499776345577 | 0.333333333333 | CTNNB1 | Afadin-beta-catenin complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CTNNB1 | CTNNA1 | 0.25 | 0.474 | hein_WMM bioplex_WMM Guru boldt hein (CTNNB1) gupta_WMM fraction boldt_WMM treiber_WMM |
| CTNNB1 | CDH10 | 0.232 | 0.47 | hein_WMM bioplex_WMM hein (CTNNB1) |
| CTNNA1 | CDH10 | 0.009 | 0.092 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02943 has an average edge precision of 0.345 which is ranked 4055 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CTNNB1 | HuMAP2_00343 HuMAP2_01868 HuMAP2_02943 HuMAP2_05814 |
| CTNNA1 | HuMAP2_00343 HuMAP2_01868 HuMAP2_02943 HuMAP2_06526 |
| CDH10 | HuMAP2_00343 HuMAP2_00625 HuMAP2_02943 |