hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02944
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SNX9 | Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A) | UniProt NCBI |
| RABIF | Guanine nucleotide exchange factor MSS4 (Rab-interacting factor) | UniProt NCBI |
| DNM3 | Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin) | UniProt NCBI |
| DNM2 | Dynamin-2 (EC 3.6.5.5) | UniProt NCBI |
| DNM1 | Dynamin-1 (EC 3.6.5.5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-177504 | 7.76884875116e-07 | 0.6 | DNM2 DNM3 DNM1 | Retrograde neurotrophin signalling |
| GO:0098844 | 3.6323771075e-06 | 0.6 | DNM2 DNM3 DNM1 | postsynaptic endocytic zone membrane |
| REAC:R-HSA-8856828 | 3.99365490063e-06 | 0.8 | DNM2 DNM3 DNM1 SNX9 | Clathrin-mediated endocytosis |
| GO:0044327 | 9.08002798436e-06 | 0.6 | DNM2 DNM3 DNM1 | dendritic spine head |
| WP:WP2267 | 1.01678610147e-05 | 0.6 | DNM2 DNM3 DNM1 | Synaptic Vesicle Pathway |
| KEGG:04961 | 1.68726386421e-05 | 0.6 | DNM2 DNM3 DNM1 | Endocrine and other factor-regulated calcium reabsorption |
| GO:0098884 | 1.81582264982e-05 | 0.6 | DNM2 DNM3 DNM1 | postsynaptic neurotransmitter receptor internalization |
| GO:0016185 | 1.81582264982e-05 | 0.6 | DNM2 DNM3 DNM1 | synaptic vesicle budding from presynaptic endocytic zone membrane |
| GO:0140239 | 1.81582264982e-05 | 0.6 | DNM2 DNM3 DNM1 | postsynaptic endocytosis |
| GO:0098843 | 3.17736949706e-05 | 0.6 | DNM2 DNM3 DNM1 | postsynaptic endocytic zone |
| GO:0070142 | 3.17736949706e-05 | 0.6 | DNM2 DNM3 DNM1 | synaptic vesicle budding |
| REAC:R-HSA-437239 | 3.84212387398e-05 | 0.6 | DNM2 DNM3 DNM1 | Recycling pathway of L1 |
| KEGG:04721 | 4.11682217947e-05 | 0.6 | DNM2 DNM3 DNM1 | Synaptic vesicle cycle |
| KEGG:05100 | 5.34171113368e-05 | 0.6 | DNM2 DNM3 DNM1 | Bacterial invasion of epithelial cells |
| GO:0099590 | 0.000108905457596 | 0.6 | DNM2 DNM3 DNM1 | neurotransmitter receptor internalization |
| REAC:R-HSA-187037 | 0.000167928044622 | 0.6 | DNM2 DNM3 DNM1 | Signaling by NTRK1 (TRKA) |
| KEGG:04072 | 0.000278060757653 | 0.6 | DNM2 DNM3 DNM1 | Phospholipase D signaling pathway |
| REAC:R-HSA-166520 | 0.000327410819085 | 0.6 | DNM2 DNM3 DNM1 | Signaling by NTRKs |
| REAC:R-HSA-373760 | 0.000596598643168 | 0.6 | DNM2 DNM3 DNM1 | L1CAM interactions |
| REAC:R-HSA-2132295 | 0.000681366686347 | 0.6 | DNM2 DNM3 DNM1 | MHC class II antigen presentation |
| REAC:R-HSA-166016 | 0.000717394603045 | 0.6 | DNM2 DNM3 DNM1 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-196025 | 0.000741476933235 | 0.4 | DNM2 DNM1 | Formation of annular gap junctions |
| REAC:R-HSA-190873 | 0.000889652787086 | 0.4 | DNM2 DNM1 | Gap junction degradation |
| REAC:R-HSA-168898 | 0.00120028939708 | 0.6 | DNM2 DNM3 DNM1 | Toll-like Receptor Cascades |
| REAC:R-HSA-199991 | 0.00166286547268 | 0.8 | DNM2 DNM3 DNM1 SNX9 | Membrane Trafficking |
| KEGG:04144 | 0.00171388219445 | 0.6 | DNM2 DNM3 DNM1 | Endocytosis |
| REAC:R-HSA-5653656 | 0.0020580612036 | 0.8 | DNM2 DNM3 DNM1 SNX9 | Vesicle-mediated transport |
| GO:0099637 | 0.00235581550516 | 0.6 | DNM2 DNM3 DNM1 | neurotransmitter receptor transport |
| GO:0099072 | 0.00265002518516 | 0.6 | DNM2 DNM3 DNM1 | regulation of postsynaptic membrane neurotransmitter receptor levels |
| GO:0000266 | 0.00330982532021 | 0.6 | DNM2 DNM3 DNM1 | mitochondrial fission |
| GO:0048489 | 0.00541762673764 | 0.6 | DNM2 DNM3 DNM1 | synaptic vesicle transport |
| GO:0006898 | 0.00558300460276 | 0.8 | DNM2 DNM3 DNM1 SNX9 | receptor-mediated endocytosis |
| GO:0140238 | 0.005924931483 | 0.6 | DNM2 DNM3 DNM1 | presynaptic endocytosis |
| GO:0048488 | 0.005924931483 | 0.6 | DNM2 DNM3 DNM1 | synaptic vesicle endocytosis |
| GO:0061024 | 0.00600585321961 | 1.0 | DNM2 RABIF DNM3 DNM1 SNX9 | membrane organization |
| REAC:R-HSA-190828 | 0.0075397219523 | 0.4 | DNM2 DNM1 | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.00799559968784 | 0.4 | DNM2 DNM1 | Gap junction trafficking and regulation |
| GO:0097479 | 0.00893946499793 | 0.6 | DNM2 DNM3 DNM1 | synaptic vesicle localization |
| GO:0036465 | 0.0111628079368 | 0.6 | DNM2 DNM3 DNM1 | synaptic vesicle recycling |
| REAC:R-HSA-432722 | 0.019180674733 | 0.4 | DNM2 SNX9 | Golgi Associated Vesicle Biogenesis |
| WP:WP4549 | 0.0215596505176 | 0.4 | DNM2 DNM1 | Fragile X Syndrome |
| REAC:R-HSA-9006934 | 0.0291077226575 | 0.6 | DNM2 DNM3 DNM1 | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-199992 | 0.0341769281663 | 0.4 | DNM2 SNX9 | trans-Golgi Network Vesicle Budding |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DNM2 | DNM3 | 0.994 | 0.921 | bioplex (DNM3) bioplex_WMM |
| DNM1 | DNM3 | 0.955 | 0.862 | bioplex (DNM3) bioplex_WMM |
| SNX9 | DNM1 | 0.134 | 0.406 | bioplex (SNX9) bioplex_WMM youn_WMM |
| SNX9 | DNM3 | 0.057 | 0.321 | bioplex (SNX9) bioplex_WMM |
| RABIF | DNM1 | 0.024 | 0.214 | bioplex_WMM fraction |
| DNM2 | DNM1 | 0.011 | 0.148 | bioplex_WMM youn_WMM WMM_only |
| SNX9 | DNM2 | 0.009 | 0.104 | bioplex (SNX9) bioplex_WMM youn_WMM gupta_WMM |
| RABIF | DNM3 | 0.003 | 0.011 | bioplex_WMM fraction |
| DNM2 | RABIF | 0.0 | 0.007 | bioplex_WMM fraction |
Images
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Complex HuMAP2_02944 has an average edge precision of 0.333 which is ranked 4202 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SNX9 | HuMAP2_00829 HuMAP2_00958 HuMAP2_02944 HuMAP2_03306 HuMAP2_06076 |
| RABIF | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 |
| DNM3 | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 HuMAP2_03916 |
| DNM2 | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 HuMAP2_03916 |
| DNM1 | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 HuMAP2_03916 |