hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02954
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SNRNP200 | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | UniProt NCBI |
| SNRNP40 | U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57) | UniProt NCBI |
| EFTUD2 | 116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa) | UniProt NCBI |
| PRPF8 | Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72165 | 2.455200129e-08 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | mRNA Splicing - Minor Pathway |
| CORUM:1181 | 6.46811126422e-08 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | C complex spliceosome |
| KEGG:03040 | 2.052638918e-07 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | Spliceosome |
| CORUM:1335 | 4.58833350325e-07 | 0.75 | SNRNP200 PRPF8 EFTUD2 | SNW1 complex |
| CORUM:351 | 6.95120006013e-07 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | Spliceosome |
| REAC:R-HSA-72163 | 3.66683425084e-06 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 4.37825325788e-06 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | mRNA Splicing |
| GO:0097525 | 9.63649068965e-06 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | spliceosomal snRNP complex |
| REAC:R-HSA-72203 | 1.12324610099e-05 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0030532 | 1.45315820527e-05 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | small nuclear ribonucleoprotein complex |
| GO:0120114 | 2.80701671762e-05 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | Sm-like protein family complex |
| GO:0071013 | 4.48297714516e-05 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | catalytic step 2 spliceosome |
| GO:0005684 | 6.52012849586e-05 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | U2-type spliceosomal complex |
| WP:WP411 | 7.12553605747e-05 | 0.75 | SNRNP40 PRPF8 EFTUD2 | mRNA Processing |
| GO:0005682 | 0.000203300410527 | 0.75 | SNRNP200 PRPF8 SNRNP40 | U5 snRNP |
| GO:0005681 | 0.000657808747052 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | spliceosomal complex |
| REAC:R-HSA-8953854 | 0.000676603019954 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | Metabolism of RNA |
| GO:0071007 | 0.00147288799354 | 0.75 | SNRNP40 PRPF8 EFTUD2 | U2-type catalytic step 2 spliceosome |
| GO:0046540 | 0.00147288799354 | 0.75 | SNRNP200 PRPF8 EFTUD2 | U4/U6 x U5 tri-snRNP complex |
| GO:0097526 | 0.00147288799354 | 0.75 | SNRNP200 PRPF8 EFTUD2 | spliceosomal tri-snRNP complex |
| GO:0030623 | 0.00270494046827 | 0.5 | EFTUD2 PRPF8 | U5 snRNA binding |
| HPA:014020_13 | 0.00593145808864 | 0.75 | SNRNP40 PRPF8 EFTUD2 | endometrium 2; glandular cells[Supported,High] |
| GO:0071005 | 0.00710332146687 | 0.75 | SNRNP200 PRPF8 EFTUD2 | U2-type precatalytic spliceosome |
| HPA:009010_13 | 0.00743886355825 | 0.75 | SNRNP40 PRPF8 EFTUD2 | cervix, uterine; glandular cells[Supported,High] |
| GO:0071011 | 0.00754689803038 | 0.75 | SNRNP200 PRPF8 EFTUD2 | precatalytic spliceosome |
| HP:0000405 | 0.00862487853069 | 0.75 | SNRNP200 PRPF8 EFTUD2 | Conductive hearing impairment |
| HP:0011452 | 0.00892789465924 | 0.75 | SNRNP200 PRPF8 EFTUD2 | Functional abnormality of the middle ear |
| GO:0000398 | 0.00944788787297 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | mRNA splicing, via spliceosome |
| GO:0000377 | 0.00944788787297 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 0.00981835447646 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | RNA splicing, via transesterification reactions |
| HPA:044010_13 | 0.0100254167787 | 0.75 | SNRNP40 PRPF8 EFTUD2 | skin 2; epidermal cells[Supported,High] |
| HPA:008030_13 | 0.0129586703655 | 0.75 | SNRNP40 PRPF8 EFTUD2 | cerebral cortex; neuronal cells[Supported,High] |
| HPA:053020_13 | 0.017188862818 | 0.75 | SNRNP40 PRPF8 EFTUD2 | testis; cells in seminiferous ducts[Supported,High] |
| GO:0008380 | 0.0187431053955 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | RNA splicing |
| HPA:057010_13 | 0.0188187097484 | 0.75 | SNRNP40 PRPF8 EFTUD2 | urinary bladder; urothelial cells[Supported,High] |
| HPA:001040_13 | 0.0188187097484 | 0.75 | SNRNP40 PRPF8 EFTUD2 | adrenal gland; glandular cells[Supported,High] |
| HPA:029010_13 | 0.0210601377494 | 0.75 | SNRNP40 PRPF8 EFTUD2 | nasopharynx; respiratory epithelial cells[Supported,High] |
| HPA:005010_13 | 0.0211895818928 | 0.75 | SNRNP40 PRPF8 EFTUD2 | bronchus; respiratory epithelial cells[Supported,High] |
| GO:0006397 | 0.0251226492241 | 1.0 | SNRNP200 PRPF8 EFTUD2 SNRNP40 | mRNA processing |
| HPA:035020_13 | 0.025175887812 | 0.75 | SNRNP40 PRPF8 EFTUD2 | placenta; trophoblastic cells[Supported,High] |
| HPA:009010_03 | 0.026657319863 | 0.75 | SNRNP40 PRPF8 EFTUD2 | cervix, uterine; glandular cells[Uncertain,High] |
| HPA:014020_03 | 0.0269603482222 | 0.75 | SNRNP40 PRPF8 EFTUD2 | endometrium 2; glandular cells[Uncertain,High] |
| HP:0000370 | 0.0278183273244 | 0.75 | SNRNP200 PRPF8 EFTUD2 | Abnormality of the middle ear |
| HPA:037010_13 | 0.0296284087039 | 0.75 | SNRNP40 PRPF8 EFTUD2 | rectum; glandular cells[Supported,High] |
| HPA:019010_13 | 0.0338599256539 | 0.75 | SNRNP40 PRPF8 EFTUD2 | gallbladder; glandular cells[Supported,High] |
| HPA:008020_12 | 0.0340369984952 | 0.75 | SNRNP40 PRPF8 EFTUD2 | cerebral cortex; glial cells[Supported,Medium] |
| HPA:044010_03 | 0.0394415317177 | 0.75 | SNRNP40 PRPF8 EFTUD2 | skin 2; epidermal cells[Uncertain,High] |
| HP:0000463 | 0.0418131938681 | 0.75 | SNRNP200 PRPF8 EFTUD2 | Anteverted nares |
| HPA:007030_12 | 0.0447431662559 | 0.75 | SNRNP40 PRPF8 EFTUD2 | cerebellum; cells in molecular layer[Supported,Medium] |
| HP:0005288 | 0.0453169017901 | 0.75 | SNRNP200 PRPF8 EFTUD2 | Abnormality of the nares |
| HPA:032020_12 | 0.0460298167372 | 0.75 | SNRNP40 PRPF8 EFTUD2 | pancreas; islets of Langerhans[Supported,Medium] |
| HPA:043010_12 | 0.0462466007541 | 0.75 | SNRNP40 PRPF8 EFTUD2 | skin 1; Langerhans[Supported,Medium] |
| HPA:006020_12 | 0.0462466007541 | 0.75 | SNRNP40 PRPF8 EFTUD2 | caudate; neuronal cells[Supported,Medium] |
| HPA:028010_12 | 0.0466821853682 | 0.75 | SNRNP40 PRPF8 EFTUD2 | lymph node; germinal center cells[Supported,Medium] |
| CORUM:1195 | 0.0499140284799 | 0.25 | PRPF8 | Exon junction complex (mRNA splicing-dependent) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EFTUD2 | SNRNP200 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SNRNP200 | PRPF8 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| EFTUD2 | PRPF8 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM |
| SNRNP40 | PRPF8 | 1.0 | 0.949 | hein_WMM bioplex (SNRNP40) bioplex_WMM Guru gupta_WMM fraction boldt_WMM |
| SNRNP40 | SNRNP200 | 1.0 | 0.949 | hein_WMM bioplex (SNRNP40) bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM |
| SNRNP40 | EFTUD2 | 1.0 | 0.949 | hein_WMM bioplex (SNRNP40) bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_02954 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SNRNP200 | HuMAP2_02954 HuMAP2_03739 HuMAP2_04421 HuMAP2_06826 |
| SNRNP40 | HuMAP2_00104 HuMAP2_02036 HuMAP2_02954 HuMAP2_04421 HuMAP2_05096 HuMAP2_05156 HuMAP2_06826 |
| EFTUD2 | HuMAP2_02837 HuMAP2_02954 HuMAP2_06826 |
| PRPF8 | HuMAP2_02954 HuMAP2_06826 |