hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02956
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CSTF2T | Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64) | UniProt NCBI |
| INTS6L | Integrator complex subunit 6-like (Protein DDX26B) | UniProt NCBI |
| CSTF1 | Cleavage stimulation factor subunit 1 (CF-1 50 kDa subunit) (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50) | UniProt NCBI |
| MTPN | Myotrophin (Protein V-1) | UniProt NCBI |
| CSTF2 | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | UniProt NCBI |
| CSTF3 | Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1146 | 2.25356268047e-09 | 0.5 | CSTF1 CSTF2 CSTF3 | Cleavage stimulation factor |
| REAC:R-HSA-77595 | 4.64286129501e-09 | 0.666666666667 | CSTF1 CSTF3 CSTF2T CSTF2 | Processing of Intronless Pre-mRNAs |
| CORUM:2211 | 2.25288169953e-08 | 0.5 | CSTF1 CSTF2 CSTF3 | BARD1-BRCA1-CSTF complex |
| REAC:R-HSA-75067 | 2.45022188621e-08 | 0.666666666667 | CSTF1 CSTF3 CSTF2T CSTF2 | Processing of Capped Intronless Pre-mRNA |
| CORUM:1147 | 7.88270302729e-08 | 0.5 | CSTF1 CSTF2 CSTF3 | Polyadenylation complex (CSTF1, CSTF2, CSTF3, SYMPK CPSF1, CPSF2, CPSF3) |
| REAC:R-HSA-72187 | 3.77396371829e-07 | 0.666666666667 | CSTF1 CSTF3 CSTF2T CSTF2 | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 7.10144453825e-07 | 0.666666666667 | CSTF1 CSTF3 CSTF2T CSTF2 | RNA Polymerase II Transcription Termination |
| KEGG:03015 | 7.82992754787e-07 | 0.666666666667 | CSTF1 CSTF3 CSTF2T CSTF2 | mRNA surveillance pathway |
| WP:WP411 | 2.89292770966e-06 | 0.666666666667 | CSTF1 CSTF3 CSTF2T CSTF2 | mRNA Processing |
| GO:0031123 | 1.62912393021e-05 | 0.833333333333 | CSTF2 CSTF1 CSTF3 CSTF2T INTS6L | RNA 3'-end processing |
| GO:0006369 | 1.90965027829e-05 | 0.666666666667 | CSTF1 CSTF3 CSTF2T CSTF2 | termination of RNA polymerase II transcription |
| REAC:R-HSA-72163 | 4.76078002862e-05 | 0.666666666667 | CSTF1 CSTF3 CSTF2T CSTF2 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 5.67951064007e-05 | 0.666666666667 | CSTF1 CSTF3 CSTF2T CSTF2 | mRNA Splicing |
| REAC:R-HSA-72203 | 0.000144935124655 | 0.666666666667 | CSTF1 CSTF3 CSTF2T CSTF2 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0006353 | 0.000395345440439 | 0.666666666667 | CSTF1 CSTF3 CSTF2T CSTF2 | DNA-templated transcription, termination |
| GO:0031124 | 0.001058235898 | 0.666666666667 | CSTF1 CSTF3 CSTF2T CSTF2 | mRNA 3'-end processing |
| GO:0006379 | 0.00147880241807 | 0.5 | CSTF3 CSTF2T CSTF2 | mRNA cleavage |
| GO:0005849 | 0.00175581235783 | 0.5 | CSTF1 CSTF2T CSTF2 | mRNA cleavage factor complex |
| REAC:R-HSA-8953854 | 0.00833913786065 | 0.666666666667 | CSTF1 CSTF3 CSTF2T CSTF2 | Metabolism of RNA |
| GO:0090501 | 0.0312028564126 | 0.5 | CSTF3 CSTF2T CSTF2 | RNA phosphodiester bond hydrolysis |
| MIRNA:hsa-miR-5581-3p | 0.0388499553328 | 0.333333333333 | MTPN CSTF2T | hsa-miR-5581-3p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CSTF2 | CSTF3 | 0.996 | 0.927 | hein_WMM bioplex_WMM youn_WMM Malo fraction treiber_WMM |
| CSTF2 | CSTF2T | 0.987 | 0.901 | hein_WMM bioplex (CSTF2T) bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| CSTF2T | CSTF3 | 0.617 | 0.674 | hein_WMM bioplex (CSTF2T) bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| CSTF2 | CSTF1 | 0.399 | 0.559 | hein_WMM bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| MTPN | CSTF3 | 0.09 | 0.355 | youn_WMM fraction |
| CSTF2 | INTS6L | 0.042 | 0.269 | fraction |
| CSTF1 | CSTF3 | 0.025 | 0.216 | hein_WMM bioplex_WMM youn_WMM Malo fraction treiber_WMM |
| CSTF1 | CSTF2T | 0.024 | 0.214 | hein_WMM bioplex (CSTF2T) bioplex_WMM Guru youn_WMM Malo fraction |
| CSTF2 | MTPN | 0.012 | 0.147 | youn_WMM gupta_WMM fraction |
| CSTF1 | MTPN | 0.005 | 0.005 | bioplex_WMM fraction |
| CSTF2T | MTPN | 0.0 | 0.017 | youn_WMM gupta_WMM fraction |
| INTS6L | CSTF2T | 0.0 | 0.016 | fraction |
Images
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Complex HuMAP2_02956 has an average edge precision of 0.358 which is ranked 3784 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CSTF2T | HuMAP2_02956 HuMAP2_06228 |
| INTS6L | HuMAP2_01150 HuMAP2_02956 HuMAP2_06201 |
| CSTF1 | HuMAP2_01150 HuMAP2_01726 HuMAP2_02956 |
| MTPN | HuMAP2_02956 HuMAP2_05296 |
| CSTF2 | HuMAP2_01150 HuMAP2_02956 HuMAP2_06228 |
| CSTF3 | HuMAP2_02956 HuMAP2_06228 |