hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02988
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PFDN2 | Prefoldin subunit 2 | UniProt NCBI |
| PFDN6 | Prefoldin subunit 6 (Protein Ke2) | UniProt NCBI |
| PFDN5 | Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1) | UniProt NCBI |
| TIPARP | Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) (TCDD-inducible poly [ADP-ribose] polymerase) | UniProt NCBI |
| PFDN1 | Prefoldin subunit 1 | UniProt NCBI |
| PFDN4 | Prefoldin subunit 4 (Protein C-1) | UniProt NCBI |
| VBP1 | Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1) | UniProt NCBI |
| MARCH9 | E3 ubiquitin-protein ligase MARCH9 (EC 2.3.2.27) (Membrane-associated RING finger protein 9) (Membrane-associated RING-CH protein IX) (MARCH-IX) (RING finger protein 179) (RING-type E3 ubiquitin transferase MARCH9) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:33 | 8.55866679422e-20 | 0.75 | VBP1 PFDN4 PFDN6 PFDN5 PFDN1 PFDN2 | Prefoldin complex |
| CORUM:112 | 8.55866679422e-20 | 0.75 | VBP1 PFDN4 PFDN6 PFDN5 PFDN1 PFDN2 | Prefoldin complex |
| REAC:R-HSA-389957 | 9.67913056005e-14 | 0.75 | VBP1 PFDN4 PFDN6 PFDN5 PFDN1 PFDN2 | Prefoldin mediated transfer of substrate to CCT/TriC |
| REAC:R-HSA-389958 | 2.40643017581e-13 | 0.75 | VBP1 PFDN4 PFDN6 PFDN5 PFDN1 PFDN2 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| GO:0016272 | 4.58747963637e-13 | 0.625 | PFDN5 PFDN6 VBP1 PFDN2 PFDN4 | prefoldin complex |
| REAC:R-HSA-390466 | 2.02110741528e-10 | 0.75 | VBP1 PFDN4 PFDN6 PFDN5 PFDN1 PFDN2 | Chaperonin-mediated protein folding |
| REAC:R-HSA-391251 | 3.00725951744e-10 | 0.75 | VBP1 PFDN4 PFDN6 PFDN5 PFDN1 PFDN2 | Protein folding |
| REAC:R-HSA-392499 | 0.0127115854598 | 0.75 | VBP1 PFDN4 PFDN6 PFDN5 PFDN1 PFDN2 | Metabolism of proteins |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PFDN2 | PFDN4 | 1.0 | 0.949 | hein_WMM bioplex (PFDN2,PFDN4) bioplex_WMM Guru boldt youn_WMM hein (PFDN2) gupta_WMM fraction boldt_WMM |
| PFDN2 | VBP1 | 1.0 | 0.949 | hein_WMM bioplex (PFDN2,VBP1) bioplex_WMM Guru boldt youn_WMM hein (PFDN2,VBP1) gupta_WMM fraction boldt_WMM |
| PFDN4 | PFDN5 | 1.0 | 0.949 | hein_WMM bioplex (PFDN4) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| VBP1 | PFDN1 | 1.0 | 0.949 | hein_WMM bioplex (VBP1) bioplex_WMM Guru boldt youn_WMM hein (VBP1) gupta_WMM fraction boldt_WMM |
| PFDN2 | PFDN5 | 1.0 | 0.949 | hein_WMM bioplex (PFDN2) bioplex_WMM Guru boldt youn_WMM hein (PFDN2) gupta_WMM fraction boldt_WMM |
| VBP1 | PFDN4 | 1.0 | 0.949 | hein_WMM bioplex (PFDN4,VBP1) bioplex_WMM Guru boldt youn_WMM hein (VBP1) gupta_WMM fraction boldt_WMM |
| VBP1 | PFDN5 | 1.0 | 0.949 | hein_WMM bioplex (VBP1) bioplex_WMM Guru boldt youn_WMM hein (VBP1) gupta_WMM fraction boldt_WMM |
| PFDN4 | PFDN6 | 1.0 | 0.949 | hein_WMM bioplex (PFDN4) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| PFDN5 | PFDN6 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| PFDN2 | PFDN1 | 1.0 | 0.949 | hein_WMM bioplex (PFDN2) bioplex_WMM Guru boldt youn_WMM hein (PFDN2) gupta_WMM fraction boldt_WMM |
| PFDN2 | PFDN6 | 1.0 | 0.949 | hein_WMM bioplex (PFDN2) bioplex_WMM Guru boldt youn_WMM hein (PFDN2) Malo gupta_WMM fraction boldt_WMM |
| VBP1 | PFDN6 | 1.0 | 0.949 | hein_WMM bioplex (VBP1) bioplex_WMM Guru boldt youn_WMM hein (VBP1) gupta_WMM fraction boldt_WMM |
| PFDN1 | PFDN5 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| PFDN1 | PFDN6 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| PFDN4 | PFDN1 | 0.999 | 0.949 | hein_WMM bioplex (PFDN4) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| PFDN4 | MARCH9 | 0.1 | 0.362 | bioplex (PFDN4) bioplex_WMM |
| PFDN2 | TIPARP | 0.051 | 0.296 | bioplex (PFDN2) bioplex_WMM youn_WMM |
| TIPARP | PFDN5 | 0.008 | 0.024 | bioplex_WMM youn_WMM WMM_only |
| TIPARP | VBP1 | 0.008 | 0.016 | bioplex_WMM youn_WMM WMM_only |
| TIPARP | PFDN1 | 0.008 | 0.016 | bioplex_WMM WMM_only |
| PFDN5 | MARCH9 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| TIPARP | PFDN4 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| TIPARP | PFDN6 | 0.007 | 0.013 | bioplex_WMM WMM_only |
| VBP1 | MARCH9 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| PFDN1 | MARCH9 | 0.007 | 0.013 | bioplex_WMM WMM_only |
| PFDN6 | MARCH9 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| PFDN2 | MARCH9 | 0.007 | 0.008 | bioplex (MARCH9) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_02988 has an average edge precision of 0.556 which is ranked 2161 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PFDN2 | HuMAP2_01751 HuMAP2_02328 HuMAP2_02428 HuMAP2_02665 HuMAP2_02988 HuMAP2_03507 |
| PFDN6 | HuMAP2_02428 HuMAP2_02665 HuMAP2_02988 |
| PFDN5 | HuMAP2_02428 HuMAP2_02665 HuMAP2_02988 HuMAP2_05617 |
| TIPARP | HuMAP2_01751 HuMAP2_02428 HuMAP2_02988 HuMAP2_03507 |
| PFDN1 | HuMAP2_02428 HuMAP2_02665 HuMAP2_02988 |
| PFDN4 | HuMAP2_02428 HuMAP2_02665 HuMAP2_02988 HuMAP2_06252 |
| VBP1 | HuMAP2_02428 HuMAP2_02665 HuMAP2_02988 |
| MARCH9 | HuMAP2_02428 HuMAP2_02988 HuMAP2_06252 |