hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02992

Confidence: High

Genename	Protein Name	Links
GTF2E2	Transcription initiation factor IIE subunit beta (TFIIE-beta) (General transcription factor IIE subunit 2)	UniProt NCBI
GTF2E1	General transcription factor IIE subunit 1 (General transcription factor IIE 56 kDa subunit) (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha)	UniProt NCBI
GTF2F2	General transcription factor IIF subunit 2 (EC 3.6.4.12) (ATP-dependent helicase GTF2F2) (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30)	UniProt NCBI
GTF2F1	General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74)	UniProt NCBI
SIN3A	Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:103	1.92670151163e-09	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA polymerase II holoenzyme complex
CORUM:2825	2.71043564135e-09	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	BRCA1-RNA polymerase II complex
KEGG:03022	1.29762871113e-08	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	Basal transcription factors
REAC:R-HSA-76042	6.49889456043e-08	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA Polymerase II Transcription Initiation And Promoter Clearance
REAC:R-HSA-75953	6.49889456043e-08	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA Polymerase II Transcription Initiation
REAC:R-HSA-73776	6.49889456043e-08	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA Polymerase II Promoter Escape
REAC:R-HSA-167162	6.49889456043e-08	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA Polymerase II HIV Promoter Escape
REAC:R-HSA-167161	6.49889456043e-08	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	HIV Transcription Initiation
REAC:R-HSA-73779	6.49889456043e-08	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
REAC:R-HSA-167172	3.53566687566e-07	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	Transcription of the HIV genome
REAC:R-HSA-6807505	4.18631702235e-07	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA polymerase II transcribes snRNA genes
REAC:R-HSA-674695	6.36085103797e-07	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA Polymerase II Pre-transcription Events
REAC:R-HSA-162599	4.51796469523e-06	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	Late Phase of HIV Life Cycle
REAC:R-HSA-162587	6.58288761159e-06	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	HIV Life Cycle
CORUM:153	6.70868171695e-06	0.4	GTF2F2 GTF2F1	TFIIF complex (transcription factor IIF)
CORUM:152	6.70868171695e-06	0.4	GTF2E1 GTF2E2	TFIIE complex
WP:WP405	7.14388071161e-06	0.6	GTF2E1 GTF2E2 GTF2F2	Eukaryotic Transcription Initiation
REAC:R-HSA-162906	3.61955824501e-05	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	HIV Infection
GO:0042795	0.000111444253056	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	snRNA transcription by RNA polymerase II
GO:0009301	0.000118091273647	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	snRNA transcription
GO:0016591	0.000125031076937	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA polymerase II, holoenzyme
REAC:R-HSA-1643685	0.000155670343335	1.0	GTF2F2 GTF2E1 GTF2F1 SIN3A GTF2E2	Disease
REAC:R-HSA-5663205	0.000241108816086	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	Infectious disease
GO:0016251	0.000259479548289	0.6	GTF2E1 GTF2E2 GTF2F1	RNA polymerase II general transcription initiation factor activity
GO:0055029	0.000403202499238	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	nuclear DNA-directed RNA polymerase complex
REAC:R-HSA-73857	0.000412889072144	1.0	GTF2F2 GTF2E1 GTF2F1 SIN3A GTF2E2	RNA Polymerase II Transcription
GO:0000428	0.00042052183524	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	DNA-directed RNA polymerase complex
GO:0030880	0.000475835425563	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA polymerase complex
GO:0098781	0.000495430747346	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	ncRNA transcription
CORUM:3064	0.000703182488552	0.4	GTF2E1 GTF2F1	RNA polymerase II complex, chromatin structure modifying
REAC:R-HSA-74160	0.000713316403356	1.0	GTF2F2 GTF2E1 GTF2F1 SIN3A GTF2E2	Gene expression (Transcription)
GO:0140223	0.000739960245213	0.6	GTF2E1 GTF2E2 GTF2F1	general transcription initiation factor activity
CORUM:2685	0.000910544014226	0.4	GTF2F2 GTF2F1	RNA polymerase II (RNAPII)
GO:0090575	0.00219868446227	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA polymerase II transcription factor complex
REAC:R-HSA-8851708	0.00230284247734	0.4	GTF2F2 GTF2F1	Signaling by FGFR2 IIIa TM
REAC:R-HSA-167242	0.00340529843133	0.4	GTF2F2 GTF2F1	Abortive elongation of HIV-1 transcript in the absence of Tat
REAC:R-HSA-1839126	0.0040368179849	0.4	GTF2F2 GTF2F1	FGFR2 mutant receptor activation
GO:0006367	0.00406013264988	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	transcription initiation from RNA polymerase II promoter
REAC:R-HSA-6803529	0.00437263170532	0.4	GTF2F2 GTF2F1	FGFR2 alternative splicing
GO:0005673	0.00450823411379	0.4	GTF2E1 GTF2E2	transcription factor TFIIE complex
GO:0005674	0.00450823411379	0.4	GTF2F2 GTF2F1	transcription factor TFIIF complex
GO:0044798	0.00456271095818	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	nuclear transcription factor complex
REAC:R-HSA-77075	0.00472180750517	0.4	GTF2F2 GTF2F1	RNA Pol II CTD phosphorylation and interaction with CE
REAC:R-HSA-167160	0.00472180750517	0.4	GTF2F2 GTF2F1	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
GO:0005669	0.00541762673764	0.6	GTF2E1 GTF2E2 GTF2F1	transcription factor TFIID complex
REAC:R-HSA-72086	0.00546022370076	0.4	GTF2F2 GTF2F1	mRNA Capping
REAC:R-HSA-167238	0.00666792835349	0.4	GTF2F2 GTF2F1	Pausing and recovery of Tat-mediated HIV elongation
REAC:R-HSA-167243	0.00666792835349	0.4	GTF2F2 GTF2F1	Tat-mediated HIV elongation arrest and recovery
REAC:R-HSA-113418	0.00709716303977	0.4	GTF2F2 GTF2F1	Formation of the Early Elongation Complex
REAC:R-HSA-167158	0.00709716303977	0.4	GTF2F2 GTF2F1	Formation of the HIV-1 Early Elongation Complex
REAC:R-HSA-5655253	0.0075397219523	0.4	GTF2F2 GTF2F1	Signaling by FGFR2 in disease
REAC:R-HSA-167287	0.0075397219523	0.4	GTF2F2 GTF2F1	HIV elongation arrest and recovery
REAC:R-HSA-167290	0.0075397219523	0.4	GTF2F2 GTF2F1	Pausing and recovery of HIV elongation
GO:0006352	0.00931766010107	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	DNA-templated transcription, initiation
REAC:R-HSA-168325	0.0104745816743	0.4	GTF2F2 GTF2F1	Viral Messenger RNA Synthesis
GO:0061695	0.0120893245383	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	transferase complex, transferring phosphorus-containing groups
REAC:R-HSA-167200	0.0126969553517	0.4	GTF2F2 GTF2F1	Formation of HIV-1 elongation complex containing HIV-1 Tat
REAC:R-HSA-167169	0.0126969553517	0.4	GTF2F2 GTF2F1	HIV Transcription Elongation
REAC:R-HSA-167246	0.0126969553517	0.4	GTF2F2 GTF2F1	Tat-mediated elongation of the HIV-1 transcript
REAC:R-HSA-167152	0.0138877528683	0.4	GTF2F2 GTF2F1	Formation of HIV elongation complex in the absence of HIV Tat
REAC:R-HSA-72165	0.017778070678	0.4	GTF2F2 GTF2F1	mRNA Splicing - Minor Pathway
REAC:R-HSA-1226099	0.0184727645209	0.4	GTF2F2 GTF2F1	Signaling by FGFR in disease
GO:0005667	0.0200611173853	0.8	GTF2E1 GTF2F1 GTF2E2 GTF2F2	transcription factor complex
REAC:R-HSA-5654738	0.0221443716613	0.4	GTF2F2 GTF2F1	Signaling by FGFR2
REAC:R-HSA-112382	0.0229182830201	0.4	GTF2F2 GTF2F1	Formation of RNA Pol II elongation complex
REAC:R-HSA-75955	0.0229182830201	0.4	GTF2F2 GTF2F1	RNA Polymerase II Transcription Elongation
REAC:R-HSA-6796648	0.0253191001807	0.4	GTF2F2 GTF2F1	TP53 Regulates Transcription of DNA Repair Genes
GO:0001097	0.0270421395626	0.4	GTF2E1 GTF2E2	TFIIH-class transcription factor complex binding
REAC:R-HSA-190236	0.0295837500362	0.4	GTF2F2 GTF2F1	Signaling by FGFR
GO:0044451	0.0442638282809	1.0	GTF2F2 GTF2E1 GTF2F1 SIN3A GTF2E2	nucleoplasm part
CORUM:0000000	0.0474603483533	1.0	GTF2F2 GTF2E1 GTF2F1 SIN3A GTF2E2	CORUM root
CORUM:720	0.0499494897235	0.2	SIN3A	PU.1-SIN3A-HDAC complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
GTF2E2	GTF2E1	1.0	0.949	hein_WMM bioplex (GTF2E2) bioplex_WMM Guru youn_WMM hein (GTF2E2) gupta_WMM fraction
GTF2F2	GTF2F1	1.0	0.949	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM
GTF2E2	GTF2F1	0.988	0.901	youn_WMM gupta_WMM fraction
GTF2E1	GTF2F1	0.987	0.902	youn_WMM gupta_WMM fraction
GTF2F1	SIN3A	0.942	0.854	youn_WMM gupta_WMM fraction
GTF2E1	GTF2F2	0.909	0.832	youn_WMM gupta_WMM fraction
GTF2E2	GTF2F2	0.718	0.73	youn_WMM gupta_WMM fraction
GTF2E2	SIN3A	0.596	0.666	youn_WMM gupta_WMM fraction
GTF2E1	SIN3A	0.585	0.663	youn_WMM gupta_WMM fraction
GTF2F2	SIN3A	0.248	0.472	youn_WMM gupta_WMM fraction

Images

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Complex HuMAP2_02992 has an average edge precision of 0.792 which is ranked 954 out of all 6965 complexes.

Related Complexes

Genename	Complexes
GTF2E2	HuMAP2_00481 HuMAP2_00694 HuMAP2_02992 HuMAP2_04413 HuMAP2_04857 HuMAP2_05709 HuMAP2_06800
GTF2E1	HuMAP2_00481 HuMAP2_00694 HuMAP2_02992 HuMAP2_04413 HuMAP2_04857 HuMAP2_06800
GTF2F2	HuMAP2_00481 HuMAP2_00694 HuMAP2_02992 HuMAP2_04857
GTF2F1	HuMAP2_00481 HuMAP2_00694 HuMAP2_02992 HuMAP2_04857
SIN3A	HuMAP2_01845 HuMAP2_02992 HuMAP2_03416

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_02992