hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02994
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ORC3 | Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) | UniProt NCBI |
| ORC6 | Origin recognition complex subunit 6 | UniProt NCBI |
| ORC2 | Origin recognition complex subunit 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:389 | 4.50712536095e-09 | 1.0 | ORC6 ORC3 ORC2 | ORC complex (origin recognition complex) |
| CORUM:1031 | 4.50712536095e-09 | 1.0 | ORC6 ORC3 ORC2 | ORC complex (origin recognition complex) |
| CORUM:5251 | 4.50712536095e-09 | 1.0 | ORC6 ORC3 ORC2 | Ku-ORC complex |
| CORUM:1033 | 4.50712536095e-09 | 1.0 | ORC6 ORC3 ORC2 | ORC complex (origin recognition complex) |
| REAC:R-HSA-68616 | 8.99193822011e-09 | 1.0 | ORC6 ORC3 ORC2 | Assembly of the ORC complex at the origin of replication |
| REAC:R-HSA-113507 | 3.77661405245e-08 | 1.0 | ORC6 ORC3 ORC2 | E2F-enabled inhibition of pre-replication complex formation |
| REAC:R-HSA-68689 | 7.41834903159e-08 | 1.0 | ORC6 ORC3 ORC2 | CDC6 association with the ORC:origin complex |
| REAC:R-HSA-113510 | 6.92379242949e-07 | 1.0 | ORC6 ORC3 ORC2 | E2F mediated regulation of DNA replication |
| WP:WP466 | 7.39430675706e-07 | 1.0 | ORC6 ORC3 ORC2 | DNA Replication |
| REAC:R-HSA-68962 | 2.45300074645e-06 | 1.0 | ORC6 ORC3 ORC2 | Activation of the pre-replicative complex |
| WP:WP45 | 2.55779891663e-06 | 1.0 | ORC6 ORC3 ORC2 | G1 to S cell cycle control |
| REAC:R-HSA-176187 | 3.49336799851e-06 | 1.0 | ORC6 ORC3 ORC2 | Activation of ATR in response to replication stress |
| GO:0005664 | 5.08584025729e-06 | 1.0 | ORC6 ORC3 ORC2 | nuclear origin of replication recognition complex |
| GO:0000808 | 5.08584025729e-06 | 1.0 | ORC6 ORC3 ORC2 | origin recognition complex |
| KEGG:04110 | 8.44552612263e-06 | 1.0 | ORC6 ORC3 ORC2 | Cell cycle |
| CORUM:1032 | 1.00675659188e-05 | 0.666666666667 | ORC3 ORC2 | ORC 2-4 complex (origin recognition 2-4 complex) |
| REAC:R-HSA-68827 | 1.46159459799e-05 | 1.0 | ORC6 ORC3 ORC2 | CDT1 association with the CDC6:ORC:origin complex |
| WP:WP179 | 1.63254441694e-05 | 1.0 | ORC6 ORC3 ORC2 | Cell Cycle |
| CORUM:1034 | 2.01342304124e-05 | 0.666666666667 | ORC3 ORC2 | ORC 2-5 complex (origin recognition 2-5 complex) |
| REAC:R-HSA-68867 | 2.2531998792e-05 | 1.0 | ORC6 ORC3 ORC2 | Assembly of the pre-replicative complex |
| REAC:R-HSA-68949 | 2.56967114485e-05 | 1.0 | ORC6 ORC3 ORC2 | Orc1 removal from chromatin |
| CORUM:1038 | 3.35555483123e-05 | 0.666666666667 | ORC3 ORC2 | ORC 1-5 complex (origin recognition 1-5 complex) |
| REAC:R-HSA-69002 | 4.44066869e-05 | 1.0 | ORC6 ORC3 ORC2 | DNA Replication Pre-Initiation |
| REAC:R-HSA-69052 | 5.10580236014e-05 | 1.0 | ORC6 ORC3 ORC2 | Switching of origins to a post-replicative state |
| REAC:R-HSA-69239 | 0.000120004609098 | 1.0 | ORC6 ORC3 ORC2 | Synthesis of DNA |
| REAC:R-HSA-69306 | 0.000146343794532 | 1.0 | ORC6 ORC3 ORC2 | DNA Replication |
| REAC:R-HSA-69206 | 0.000160847790881 | 1.0 | ORC6 ORC3 ORC2 | G1/S Transition |
| GO:0003688 | 0.000183816797871 | 1.0 | ORC6 ORC3 ORC2 | DNA replication origin binding |
| REAC:R-HSA-453279 | 0.000233190181847 | 1.0 | ORC6 ORC3 ORC2 | Mitotic G1-G1/S phases |
| REAC:R-HSA-69242 | 0.000295546575822 | 1.0 | ORC6 ORC3 ORC2 | S Phase |
| REAC:R-HSA-69481 | 0.00034275245309 | 1.0 | ORC6 ORC3 ORC2 | G2/M Checkpoints |
| GO:0006270 | 0.000368723418654 | 1.0 | ORC6 ORC3 ORC2 | DNA replication initiation |
| REAC:R-HSA-69620 | 0.00175293114833 | 1.0 | ORC6 ORC3 ORC2 | Cell Cycle Checkpoints |
| REAC:R-HSA-69278 | 0.0102351006549 | 1.0 | ORC6 ORC3 ORC2 | Cell Cycle, Mitotic |
| REAC:R-HSA-1640170 | 0.0176005573074 | 1.0 | ORC6 ORC3 ORC2 | Cell Cycle |
| GO:0006261 | 0.0302766427817 | 1.0 | ORC6 ORC3 ORC2 | DNA-dependent DNA replication |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ORC6 | ORC2 | 0.702 | 0.723 | bioplex (ORC6) bioplex_WMM |
| ORC3 | ORC2 | 0.109 | 0.378 | bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| ORC6 | ORC3 | 0.009 | 0.107 | Guru fraction |
Images
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Complex HuMAP2_02994 has an average edge precision of 0.403 which is ranked 3286 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ORC3 | HuMAP2_00864 HuMAP2_01115 HuMAP2_02994 HuMAP2_04533 HuMAP2_04597 |
| ORC6 | HuMAP2_00864 HuMAP2_02994 HuMAP2_04398 HuMAP2_04533 |
| ORC2 | HuMAP2_00864 HuMAP2_02994 HuMAP2_04398 HuMAP2_04533 HuMAP2_04597 |