hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02995
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SYNRG | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | UniProt NCBI |
| AP1S2 | AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin) | UniProt NCBI |
| AP1G2 | AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad) | UniProt NCBI |
| AP1M2 | AP-1 complex subunit mu-2 (AP-mu chain family member mu1B) (Adaptor protein complex AP-1 subunit mu-2) (Adaptor-related protein complex 1 subunit mu-2) (Clathrin assembly protein complex 1 mu-2 medium chain 2) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Mu-adaptin 2) (Mu1B-adaptin) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:36 | 3.78034162849e-08 | 0.75 | AP1S2 AP1G2 AP1M2 | AP1 adaptor complex |
| CORUM:144 | 5.67022676981e-08 | 0.75 | AP1S2 AP1G2 AP1M2 | Gamma-BAR-AP1 complex |
| REAC:R-HSA-432720 | 8.82452886806e-06 | 0.75 | AP1S2 AP1G2 AP1M2 | Lysosome Vesicle Biogenesis |
| KEGG:04142 | 7.14089641582e-05 | 0.75 | AP1S2 AP1G2 AP1M2 | Lysosome |
| REAC:R-HSA-199992 | 8.02616571278e-05 | 0.75 | AP1S2 AP1G2 AP1M2 | trans-Golgi Network Vesicle Budding |
| KEGG:05170 | 0.000344687561831 | 0.75 | AP1S2 AP1G2 AP1M2 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-164940 | 0.000361772624521 | 0.5 | AP1S2 AP1M2 | Nef mediated downregulation of MHC class I complex cell surface expression |
| GO:0030119 | 0.00132566605022 | 0.75 | AP1S2 AP1G2 SYNRG | AP-type membrane coat adaptor complex |
| REAC:R-HSA-164938 | 0.00153629461685 | 0.5 | AP1S2 AP1M2 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| REAC:R-HSA-164952 | 0.00276986547413 | 0.5 | AP1S2 AP1M2 | The role of Nef in HIV-1 replication and disease pathogenesis |
| REAC:R-HSA-432722 | 0.0143225711665 | 0.5 | AP1S2 AP1M2 | Golgi Associated Vesicle Biogenesis |
| GO:0030117 | 0.0225145500348 | 0.75 | AP1S2 AP1G2 SYNRG | membrane coat |
| GO:0048475 | 0.0225145500348 | 0.75 | AP1S2 AP1G2 SYNRG | coated membrane |
| GO:0030121 | 0.0270421395626 | 0.5 | SYNRG AP1G2 | AP-1 adaptor complex |
| REAC:R-HSA-199991 | 0.0426366599823 | 0.75 | AP1S2 AP1G2 AP1M2 | Membrane Trafficking |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SYNRG | AP1S2 | 1.0 | 0.949 | hein_WMM bioplex (AP1S2) bioplex_WMM youn_WMM hein (AP1S2) |
| AP1S2 | AP1G2 | 0.998 | 0.941 | hein_WMM bioplex (AP1S2) bioplex_WMM hein (AP1S2) |
| AP1M2 | AP1S2 | 0.994 | 0.92 | bioplex (AP1M2) bioplex_WMM |
| AP1M2 | AP1G2 | 0.827 | 0.774 | bioplex (AP1M2) bioplex_WMM |
| SYNRG | AP1G2 | 0.042 | 0.27 | hein_WMM bioplex (AP1G2) bioplex_WMM |
Images
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Complex HuMAP2_02995 has an average edge precision of 0.771 which is ranked 1051 out of all 6965 complexes.
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