hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03001

Confidence: Medium

Genename	Protein Name	Links
LIN7B	Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)	UniProt NCBI
ARHGEF26	Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor)	UniProt NCBI
LIN7C	Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)	UniProt NCBI
APBA1	Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1)	UniProt NCBI
EFNB3	Ephrin-B3 (EPH-related receptor transmembrane ligand ELK-L3) (EPH-related receptor tyrosine kinase ligand 8) (LERK-8)	UniProt NCBI
LIN7A	Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1)	UniProt NCBI
ABLIM2	Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2)	UniProt NCBI
AMOTL2	Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP)	UniProt NCBI
CRB3	Protein crumbs homolog 3	UniProt NCBI
MPP5	MAGUK p55 subfamily member 5	UniProt NCBI
MPDZ	Multiple PDZ domain protein (Multi-PDZ domain protein 1)	UniProt NCBI
MPP6	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1)	UniProt NCBI
MPP2	MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2)	UniProt NCBI
CASK	Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)	UniProt NCBI
MPP3	MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3)	UniProt NCBI
DLG1	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)	UniProt NCBI
MPP7	MAGUK p55 subfamily member 7	UniProt NCBI
KIF26B	Kinesin-like protein KIF26B	UniProt NCBI
PATJ		NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:3207	6.16945601133e-11	0.222222222222	DLG1 CASK APBA1 LIN7A	LIN2-LIN7-SAP97-MINT1 complex
GO:0097025	7.01884384365e-11	0.277777777778	LIN7C DLG1 LIN7A LIN7B MPP7	MPP7-DLG1-LIN7 complex
REAC:R-HSA-9609736	9.456061804e-10	0.333333333333	LIN7C APBA1 LIN7A DLG1 CASK LIN7B	Assembly and cell surface presentation of NMDA receptors
CORUM:848	2.15444056267e-09	0.222222222222	MPDZ MPP7 MPP5 AMOTL2	RICH1/AMOT polarity complex, Flag-Amot precipitated
REAC:R-HSA-212676	8.06698855393e-09	0.277777777778	LIN7A LIN7C CASK LIN7B APBA1	Dopamine Neurotransmitter Release Cycle
CORUM:6260	6.12462463098e-08	0.166666666667	DLG1 LIN7A MPP7	MPP7-DLG1-LIN7A complex
CORUM:617	6.12462463098e-08	0.166666666667	LIN7C APBA1 CASK	CASK-LIN7C-APBA1 complex
CORUM:1448	6.12462463098e-08	0.166666666667	DLG1 LIN7A CASK	LIN2-LIN7-SAP97 complex
CORUM:6263	6.12462463098e-08	0.166666666667	LIN7C DLG1 MPP7	MPP7-DLG1-LIN7C complex
GO:0097016	7.46504177371e-08	0.222222222222	LIN7A DLG1 LIN7B LIN7C	L27 domain binding
REAC:R-HSA-6794362	1.07901119593e-07	0.333333333333	LIN7C APBA1 LIN7A DLG1 CASK LIN7B	Protein-protein interactions at synapses
REAC:R-HSA-442755	1.34863611391e-07	0.333333333333	LIN7C APBA1 LIN7A DLG1 CASK LIN7B	Activation of NMDA receptors and postsynaptic events
REAC:R-HSA-112310	2.25274733477e-07	0.277777777778	LIN7A LIN7C CASK LIN7B APBA1	Neurotransmitter release cycle
REAC:R-HSA-6794361	1.11141270333e-06	0.277777777778	LIN7A LIN7C CASK LIN7B APBA1	Neurexins and neuroligins
REAC:R-HSA-112314	1.13937274585e-05	0.333333333333	LIN7C APBA1 LIN7A DLG1 CASK LIN7B	Neurotransmitter receptors and postsynaptic signal transmission
GO:0005911	2.08553109369e-05	0.444444444444	LIN7C AMOTL2 MPP5 LIN7A DLG1 CASK MPP7 LIN7B	cell-cell junction
KEGG:04530	3.5196353927e-05	0.277777777778	MPDZ DLG1 CRB3 MPP5 AMOTL2	Tight junction
REAC:R-HSA-112315	5.3399739109e-05	0.333333333333	LIN7C APBA1 LIN7A DLG1 CASK LIN7B	Transmission across Chemical Synapses
CORUM:3209	5.70049437529e-05	0.111111111111	DLG1 CASK	LIN2-SAP97 complex
CORUM:1089	5.70049437529e-05	0.111111111111	MPP6 LIN7A	VAM1-VELI1 complex
CORUM:3208	5.70049437529e-05	0.111111111111	LIN7A CASK	LIN2-LIN7 complex
REAC:R-HSA-112316	0.00057942416542	0.333333333333	LIN7C APBA1 LIN7A DLG1 CASK LIN7B	Neuronal System
GO:0007163	0.00104219646626	0.333333333333	LIN7C AMOTL2 LIN7A DLG1 MPP7 LIN7B	establishment or maintenance of cell polarity
GO:0030054	0.00150014875413	0.5	LIN7C AMOTL2 MPP5 LIN7A DLG1 CASK MPP7 CRB3 LIN7B	cell junction
GO:0045197	0.00200614748589	0.222222222222	LIN7A DLG1 LIN7B LIN7C	establishment or maintenance of epithelial cell apical/basal polarity
GO:1903361	0.00258594907681	0.166666666667	LIN7C LIN7B LIN7A	protein localization to basolateral plasma membrane
GO:0035088	0.00298873667437	0.222222222222	LIN7A DLG1 LIN7B LIN7C	establishment or maintenance of apical/basal cell polarity
GO:0061245	0.00298873667437	0.222222222222	LIN7A DLG1 LIN7B LIN7C	establishment or maintenance of bipolar cell polarity
GO:0099643	0.00342110879509	0.277777777778	LIN7A LIN7C CASK LIN7B APBA1	signal release from synapse
GO:0007269	0.00342110879509	0.277777777778	LIN7A LIN7C CASK LIN7B APBA1	neurotransmitter secretion
GO:0045199	0.00413439262839	0.166666666667	LIN7C LIN7B LIN7A	maintenance of epithelial cell apical/basal polarity
GO:0035090	0.00413439262839	0.166666666667	LIN7C LIN7B LIN7A	maintenance of apical/basal cell polarity
GO:0007268	0.006682770142	0.388888888889	LIN7C APBA1 LIN7A DLG1 CASK MPP2 LIN7B	chemical synaptic transmission
GO:0098916	0.006682770142	0.388888888889	LIN7C APBA1 LIN7A DLG1 CASK MPP2 LIN7B	anterograde trans-synaptic signaling
GO:0070830	0.00735218495702	0.222222222222	DLG1 CRB3 MPP5 MPP7	bicellular tight junction assembly
GO:0099537	0.00746121300813	0.388888888889	LIN7C APBA1 LIN7A DLG1 CASK MPP2 LIN7B	trans-synaptic signaling
GO:0120192	0.00811998132117	0.222222222222	DLG1 CRB3 MPP5 MPP7	tight junction assembly
GO:0099536	0.00958108434933	0.388888888889	LIN7C APBA1 LIN7A DLG1 CASK MPP2 LIN7B	synaptic signaling
GO:0120193	0.00983325643627	0.222222222222	DLG1 CRB3 MPP5 MPP7	tight junction organization
GO:0043297	0.0140521906578	0.222222222222	DLG1 CRB3 MPP5 MPP7	apical junction assembly
GO:0019904	0.0169416023101	0.388888888889	LIN7C MPP5 LIN7A DLG1 MPP7 CRB3 LIN7B	protein domain specific binding
GO:0030011	0.0210352917967	0.166666666667	LIN7C LIN7B LIN7A	maintenance of cell polarity
CORUM:0000000	0.0236602751626	0.611111111111	LIN7C APBA1 MPDZ AMOTL2 MPP3 MPP5 LIN7A DLG1 CASK MPP7 MPP6	CORUM root
GO:0005912	0.0286017565191	0.388888888889	LIN7C MPP5 LIN7A DLG1 CASK MPP7 LIN7B	adherens junction
GO:0006836	0.0315711294725	0.277777777778	LIN7A LIN7C CASK LIN7B APBA1	neurotransmitter transport
GO:0070161	0.0335871118596	0.388888888889	LIN7C MPP5 LIN7A DLG1 CASK MPP7 LIN7B	anchoring junction
REAC:R-HSA-420029	0.0410019697936	0.111111111111	CRB3 MPP5	Tight junction interactions

Edges

Protein 1	Protein 2	Score	Precision	Evidence
LIN7C	MPDZ	1.0	0.949	hein_WMM bioplex (LIN7C) bioplex_WMM hein (LIN7C)
LIN7C	DLG1	1.0	0.949	hein_WMM bioplex (LIN7C) bioplex_WMM hein (LIN7C) gupta_WMM
LIN7C	PATJ	1.0	0.949	hein_WMM bioplex (LIN7C) bioplex_WMM hein (LIN7C)
LIN7C	MPP7	1.0	0.949	hein_WMM bioplex (LIN7C) bioplex_WMM hein (LIN7C)
LIN7C	MPP2	1.0	0.949	bioplex (LIN7C,MPP2) bioplex_WMM
LIN7C	CASK	1.0	0.949	hein_WMM bioplex (LIN7C) bioplex_WMM hein (LIN7C)
LIN7C	MPP5	1.0	0.949	hein_WMM bioplex (LIN7C,MPP5) bioplex_WMM hein (LIN7C) gupta_WMM
LIN7C	MPP6	1.0	0.949	hein_WMM bioplex (LIN7C) bioplex_WMM hein (LIN7C,MPP6)
LIN7C	APBA1	1.0	0.949	bioplex (LIN7C) bioplex_WMM
LIN7B	LIN7C	1.0	0.949	bioplex (LIN7C) bioplex_WMM
LIN7B	MPP2	0.963	0.871	bioplex (MPP2) bioplex_WMM
MPDZ	MPP5	0.916	0.84	hein_WMM bioplex (MPP5) bioplex_WMM fraction
LIN7C	ABLIM2	0.855	0.793	bioplex (LIN7C) bioplex_WMM
PATJ	MPP5	0.823	0.774	hein_WMM bioplex (MPP5) bioplex_WMM
LIN7C	KIF26B	0.821	0.773	hein_WMM bioplex (LIN7C) bioplex_WMM hein (KIF26B)
CRB3	MPP5	0.782	0.756	bioplex (MPP5) bioplex_WMM
LIN7C	MPP3	0.664	0.698	bioplex (LIN7C) bioplex_WMM
MPP2	DLG1	0.601	0.671	bioplex (MPP2) bioplex_WMM
LIN7B	MPP5	0.592	0.665	bioplex (MPP5) bioplex_WMM
AMOTL2	MPP5	0.587	0.662	hein_WMM bioplex (MPP5) bioplex_WMM
LIN7C	ARHGEF26	0.484	0.614	bioplex (LIN7C) bioplex_WMM
LIN7A	MPP2	0.456	0.596	bioplex (MPP2) bioplex_WMM
MPP7	EFNB3	0.146	0.408	bioplex (EFNB3) bioplex_WMM
MPP6	MPP2	0.024	0.213	bioplex (MPP2) bioplex_WMM
MPP5	LIN7A	0.021	0.189	bioplex (MPP5) bioplex_WMM
MPP6	LIN7A	0.012	0.149	bioplex_WMM WMM_only
DLG1	MPP7	0.012	0.152	hein_WMM bioplex_WMM youn_WMM WMM_only
LIN7C	LIN7A	0.011	0.148	bioplex_WMM WMM_only
MPP7	CASK	0.011	0.138	hein_WMM bioplex_WMM youn_WMM WMM_only
LIN7B	DLG1	0.011	0.141	bioplex_WMM WMM_only
LIN7B	MPDZ	0.011	0.141	bioplex_WMM WMM_only
MPDZ	PATJ	0.011	0.141	hein_WMM bioplex_WMM WMM_only
DLG1	CASK	0.01	0.139	hein_WMM bioplex_WMM youn_WMM WMM_only
LIN7B	PATJ	0.01	0.139	bioplex_WMM WMM_only
AMOTL2	LIN7C	0.01	0.122	hein_WMM bioplex_WMM hein (LIN7C)
ABLIM2	MPP3	0.01	0.105	bioplex_WMM WMM_only
ABLIM2	KIF26B	0.01	0.105	bioplex_WMM WMM_only
KIF26B	MPP3	0.01	0.105	bioplex_WMM WMM_only
MPP5	MPP7	0.009	0.111	hein_WMM bioplex_WMM WMM_only
MPP5	DLG1	0.009	0.114	hein_WMM bioplex_WMM gupta_WMM WMM_only
APBA1	MPP3	0.009	0.104	bioplex_WMM WMM_only
APBA1	ABLIM2	0.009	0.104	bioplex_WMM WMM_only
APBA1	KIF26B	0.009	0.104	bioplex_WMM WMM_only
LIN7B	MPP6	0.009	0.11	bioplex_WMM WMM_only
CASK	MPP3	0.009	0.107	bioplex_WMM WMM_only
ABLIM2	CASK	0.009	0.107	bioplex_WMM WMM_only
ABLIM2	MPP7	0.009	0.107	bioplex_WMM WMM_only
DLG1	MPP3	0.009	0.107	bioplex_WMM WMM_only
DLG1	ABLIM2	0.009	0.107	bioplex_WMM WMM_only
MPP7	MPP3	0.009	0.107	bioplex_WMM WMM_only
MPDZ	MPP3	0.009	0.107	bioplex_WMM WMM_only
MPDZ	KIF26B	0.009	0.107	bioplex_WMM WMM_only
MPDZ	ABLIM2	0.009	0.107	bioplex_WMM WMM_only
LIN7B	ABLIM2	0.009	0.102	bioplex_WMM WMM_only
LIN7B	MPP3	0.009	0.102	bioplex_WMM WMM_only
LIN7B	KIF26B	0.009	0.102	bioplex_WMM WMM_only
MPP5	CASK	0.009	0.108	hein_WMM bioplex_WMM WMM_only
LIN7B	LIN7A	0.009	0.109	bioplex_WMM WMM_only
PATJ	MPP3	0.009	0.107	bioplex_WMM WMM_only
PATJ	KIF26B	0.009	0.107	bioplex_WMM WMM_only
PATJ	ABLIM2	0.009	0.107	bioplex_WMM WMM_only
ARHGEF26	MPP3	0.009	0.108	bioplex_WMM WMM_only
ABLIM2	ARHGEF26	0.009	0.108	bioplex_WMM WMM_only
ARHGEF26	KIF26B	0.009	0.108	bioplex_WMM WMM_only
MPP5	ABLIM2	0.009	0.101	bioplex_WMM WMM_only
MPP2	KIF26B	0.009	0.101	bioplex_WMM WMM_only
MPP5	KIF26B	0.009	0.101	bioplex_WMM WMM_only
MPP5	MPP3	0.009	0.101	bioplex_WMM WMM_only
MPP2	ABLIM2	0.009	0.101	bioplex_WMM WMM_only
MPP2	MPP3	0.009	0.101	bioplex_WMM WMM_only
MPP6	MPP7	0.009	0.101	hein_WMM bioplex_WMM WMM_only
MPDZ	MPP7	0.009	0.102	hein_WMM bioplex_WMM WMM_only
APBA1	CASK	0.009	0.099	bioplex_WMM WMM_only
MPDZ	APBA1	0.009	0.103	bioplex_WMM WMM_only
APBA1	DLG1	0.009	0.103	bioplex_WMM WMM_only
APBA1	MPP7	0.009	0.103	bioplex_WMM WMM_only
LIN7B	APBA1	0.009	0.092	bioplex_WMM WMM_only
LIN7B	CASK	0.009	0.095	bioplex_WMM WMM_only
PATJ	APBA1	0.009	0.094	bioplex_WMM WMM_only
LIN7B	MPP7	0.009	0.094	bioplex_WMM WMM_only
MPDZ	DLG1	0.009	0.095	hein_WMM bioplex_WMM WMM_only
APBA1	ARHGEF26	0.009	0.095	bioplex_WMM WMM_only
MPP5	MPP6	0.009	0.095	hein_WMM bioplex_WMM WMM_only
MPP2	APBA1	0.009	0.099	bioplex_WMM WMM_only
MPP5	APBA1	0.009	0.099	bioplex_WMM WMM_only
AMOTL2	MPDZ	0.009	0.096	hein_WMM bioplex_WMM WMM_only
PATJ	MPP7	0.009	0.099	hein_WMM bioplex_WMM WMM_only
ARHGEF26	CASK	0.009	0.097	bioplex_WMM WMM_only
MPDZ	ARHGEF26	0.009	0.098	bioplex_WMM WMM_only
DLG1	ARHGEF26	0.009	0.098	bioplex_WMM WMM_only
MPP7	ARHGEF26	0.009	0.098	bioplex_WMM WMM_only
LIN7B	ARHGEF26	0.009	0.096	bioplex_WMM WMM_only
MPP2	CASK	0.009	0.092	bioplex_WMM WMM_only
MPDZ	MPP2	0.008	0.094	bioplex_WMM WMM_only
MPP2	MPP7	0.008	0.094	bioplex_WMM WMM_only
MPP6	CASK	0.008	0.094	hein_WMM bioplex_WMM WMM_only
MPDZ	CASK	0.008	0.094	hein_WMM bioplex_WMM WMM_only
CRB3	MPDZ	0.008	0.093	bioplex_WMM WMM_only
CRB3	AMOTL2	0.008	0.091	bioplex_WMM WMM_only
PATJ	ARHGEF26	0.008	0.088	bioplex_WMM WMM_only
PATJ	DLG1	0.008	0.085	hein_WMM bioplex_WMM WMM_only
MPP6	KIF26B	0.008	0.087	bioplex_WMM WMM_only
MPP6	ABLIM2	0.008	0.087	bioplex_WMM WMM_only
MPP6	MPP3	0.008	0.087	bioplex_WMM WMM_only
PATJ	MPP2	0.008	0.089	bioplex_WMM WMM_only
MPP2	ARHGEF26	0.008	0.091	bioplex_WMM WMM_only
MPP5	ARHGEF26	0.008	0.091	bioplex_WMM WMM_only
CRB3	PATJ	0.008	0.087	bioplex_WMM WMM_only
LIN7B	CRB3	0.008	0.087	bioplex_WMM WMM_only
MPP5	MPP2	0.008	0.084	bioplex_WMM WMM_only
PATJ	CASK	0.008	0.086	hein_WMM bioplex_WMM WMM_only
AMOTL2	PATJ	0.008	0.085	hein_WMM bioplex_WMM WMM_only
MPDZ	MPP6	0.008	0.079	hein_WMM bioplex_WMM WMM_only
MPP6	APBA1	0.008	0.08	bioplex_WMM WMM_only
CRB3	LIN7A	0.008	0.068	bioplex_WMM WMM_only
LIN7B	AMOTL2	0.008	0.067	bioplex_WMM WMM_only
CRB3	LIN7C	0.008	0.07	bioplex_WMM WMM_only
LIN7A	DLG1	0.008	0.047	bioplex_WMM gupta_WMM WMM_only
PATJ	MPP6	0.008	0.044	hein_WMM bioplex_WMM WMM_only
MPP6	ARHGEF26	0.008	0.043	bioplex_WMM WMM_only
MPDZ	LIN7A	0.008	0.044	bioplex_WMM WMM_only
AMOTL2	LIN7A	0.008	0.046	bioplex_WMM WMM_only
MPP6	DLG1	0.008	0.029	hein_WMM bioplex_WMM fraction
PATJ	LIN7A	0.008	0.019	bioplex_WMM WMM_only
AMOTL2	MPP7	0.008	0.012	hein_WMM WMM_only
AMOTL2	MPP6	0.008	0.012	hein_WMM WMM_only
AMOTL2	DLG1	0.007	0.008	hein_WMM WMM_only
AMOTL2	CASK	0.007	0.001	hein_WMM WMM_only
DLG1	EFNB3	0.005	0.013	bioplex (EFNB3) bioplex_WMM
MPP7	KIF26B	0.004	0.012	hein_WMM bioplex_WMM hein (KIF26B)
DLG1	KIF26B	0.004	0.017	hein_WMM bioplex_WMM hein (KIF26B)
LIN7C	EFNB3	0.003	0.01	bioplex (EFNB3) bioplex_WMM
KIF26B	CASK	0.003	0.011	hein_WMM bioplex_WMM hein (KIF26B)

Images

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Complex HuMAP2_03001 has an average edge precision of 0.216 which is ranked 5917 out of all 6965 complexes.

Related Complexes

Genename	Complexes
LIN7B	HuMAP2_01171 HuMAP2_01555 HuMAP2_02238 HuMAP2_03001
ARHGEF26	HuMAP2_03001 HuMAP2_04362 HuMAP2_05173
LIN7C	HuMAP2_01171 HuMAP2_02238 HuMAP2_03001
APBA1	HuMAP2_02083 HuMAP2_03001 HuMAP2_05182 HuMAP2_05226
EFNB3	HuMAP2_03001 HuMAP2_03371
LIN7A	HuMAP2_01555 HuMAP2_02238 HuMAP2_03001
ABLIM2	HuMAP2_03001
AMOTL2	HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_04011 HuMAP2_04805
CRB3	HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_04805
MPP5	HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_04805
MPDZ	HuMAP2_01171 HuMAP2_02238 HuMAP2_03001
MPP6	HuMAP2_01555 HuMAP2_02238 HuMAP2_03001
MPP2	HuMAP2_01555 HuMAP2_02238 HuMAP2_03001
CASK	HuMAP2_03001
MPP3	HuMAP2_03001
DLG1	HuMAP2_03001 HuMAP2_03840 HuMAP2_06395
MPP7	HuMAP2_03001 HuMAP2_03371
KIF26B	HuMAP2_03001
PATJ	HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_03401

hu.MAP 2.0: Complex View

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Complex: HuMAP2_03001