hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03002

Confidence: High

Genename	Protein Name	Links
AP2A2	AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)	UniProt NCBI
AP2S1	AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)	UniProt NCBI
AP2M1	AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)	UniProt NCBI
STON2	Stonin-2 (Stoned B)	UniProt NCBI
AAK1	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)	UniProt NCBI
CCDC32	Coiled-coil domain-containing protein 32	UniProt NCBI
FCHO2	F-BAR domain only protein 2	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8856825	4.46966038931e-11	0.857142857143	AP2M1 STON2 AP2S1 AAK1 AP2A2 FCHO2	Cargo recognition for clathrin-mediated endocytosis
REAC:R-HSA-8856828	4.36501226558e-10	0.857142857143	AP2M1 STON2 AP2S1 AAK1 AP2A2 FCHO2	Clathrin-mediated endocytosis
GO:0072583	2.91448618104e-08	0.714285714286	FCHO2 AP2M1 AP2A2 AP2S1 AAK1	clathrin-dependent endocytosis
REAC:R-HSA-182218	2.12490255518e-07	0.428571428571	AP2M1 AP2S1 AP2A2	Nef Mediated CD8 Down-regulation
REAC:R-HSA-167590	8.91919699889e-07	0.428571428571	AP2M1 AP2S1 AP2A2	Nef Mediated CD4 Down-regulation
REAC:R-HSA-8866427	2.33456820519e-06	0.428571428571	AP2M1 AP2S1 AP2A2	VLDLR internalisation and degradation
REAC:R-HSA-5140745	3.0343270142e-06	0.428571428571	AP2M1 AP2S1 AP2A2	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
REAC:R-HSA-177504	3.0343270142e-06	0.428571428571	AP2M1 AP2S1 AP2A2	Retrograde neurotrophin signalling
REAC:R-HSA-5099900	3.861092404e-06	0.428571428571	AP2M1 AP2S1 AP2A2	WNT5A-dependent internalization of FZD4
REAC:R-HSA-199991	3.8900451489e-06	0.857142857143	AP2M1 STON2 AP2S1 AAK1 AP2A2 FCHO2	Membrane Trafficking
REAC:R-HSA-5653656	5.36316718014e-06	0.857142857143	AP2M1 STON2 AP2S1 AAK1 AP2A2 FCHO2	Vesicle-mediated transport
REAC:R-HSA-164938	8.64865911977e-06	0.428571428571	AP2M1 AP2S1 AP2A2	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
WP:WP4159	9.84327665897e-06	0.428571428571	AP2M1 AP2S1 AP2A2	GABA receptor Signaling
REAC:R-HSA-8964038	1.02682123619e-05	0.428571428571	AP2M1 AP2S1 AP2A2	LDL clearance
REAC:R-HSA-164952	2.14261301225e-05	0.428571428571	AP2M1 AP2S1 AP2A2	The role of Nef in HIV-1 replication and disease pathogenesis
GO:0005905	3.47762626669e-05	0.571428571429	AP2M1 AP2A2 AP2S1 FCHO2	clathrin-coated pit
REAC:R-HSA-8964043	3.86423784685e-05	0.428571428571	AP2M1 AP2S1 AP2A2	Plasma lipoprotein clearance
GO:0030136	4.48890323453e-05	0.714285714286	FCHO2 AP2M1 AP2A2 AP2S1 AAK1	clathrin-coated vesicle
GO:0006897	4.73476306304e-05	0.857142857143	AP2M1 STON2 AP2S1 AAK1 AP2A2 FCHO2	endocytosis
WP:WP2267	5.08886364153e-05	0.428571428571	AP2M1 AP2S1 AP2A2	Synaptic Vesicle Pathway
KEGG:04961	6.46895232318e-05	0.428571428571	AP2M1 AP2S1 AP2A2	Endocrine and other factor-regulated calcium reabsorption
REAC:R-HSA-437239	0.000149580766655	0.428571428571	AP2M1 AP2S1 AP2A2	Recycling pathway of L1
KEGG:04721	0.000157567942176	0.428571428571	AP2M1 AP2S1 AP2A2	Synaptic vesicle cycle
REAC:R-HSA-3928665	0.000159984341908	0.428571428571	AP2M1 AP2S1 AP2A2	EPH-ephrin mediated repulsion of cells
GO:0030122	0.000177825159425	0.428571428571	AP2M1 AP2S1 AP2A2	AP-2 adaptor complex
GO:0030128	0.000177825159425	0.428571428571	AP2M1 AP2S1 AP2A2	clathrin coat of endocytic vesicle
GO:0098657	0.00024451746594	0.857142857143	AP2M1 STON2 AP2S1 AAK1 AP2A2 FCHO2	import into cell
GO:0035615	0.000266683990267	0.428571428571	AP2M1 AP2S1 AP2A2	clathrin adaptor activity
GO:0030132	0.000266683990267	0.428571428571	AP2M1 AP2S1 AP2A2	clathrin coat of coated pit
GO:0006898	0.000280524408965	0.714285714286	FCHO2 AP2M1 AP2A2 AP2S1 AAK1	receptor-mediated endocytosis
REAC:R-HSA-174824	0.000291556160225	0.428571428571	AP2M1 AP2S1 AP2A2	Plasma lipoprotein assembly, remodeling, and clearance
GO:0140312	0.000380900357231	0.428571428571	AP2M1 AP2S1 AP2A2	cargo adaptor activity
GO:0036020	0.000523632447094	0.428571428571	AP2M1 AP2S1 AP2A2	endolysosome membrane
GO:0030135	0.000532417273347	0.714285714286	FCHO2 AP2M1 AP2A2 AP2S1 AAK1	coated vesicle
REAC:R-HSA-187037	0.000651928894468	0.428571428571	AP2M1 AP2S1 AP2A2	Signaling by NTRK1 (TRKA)
GO:0030131	0.000907263777246	0.428571428571	AP2M1 AP2S1 AP2A2	clathrin adaptor complex
REAC:R-HSA-2682334	0.00106989745097	0.428571428571	AP2M1 AP2S1 AP2A2	EPH-Ephrin signaling
REAC:R-HSA-166520	0.00126876263254	0.428571428571	AP2M1 AP2S1 AP2A2	Signaling by NTRKs
REAC:R-HSA-4086400	0.00126876263254	0.428571428571	AP2M1 AP2S1 AP2A2	PCP/CE pathway
GO:0032802	0.00144279242783	0.428571428571	AP2M1 AP2S1 AP2A2	low-density lipoprotein particle receptor catabolic process
GO:0061024	0.00166727147917	0.857142857143	AP2M1 STON2 AP2S1 AAK1 AP2A2 FCHO2	membrane organization
GO:0036019	0.001775386605	0.428571428571	AP2M1 AP2S1 AP2A2	endolysosome
REAC:R-HSA-373760	0.00230723415657	0.428571428571	AP2M1 AP2S1 AP2A2	L1CAM interactions
GO:0030125	0.00258594907681	0.428571428571	AP2M1 AP2S1 AP2A2	clathrin vesicle coat
REAC:R-HSA-2132295	0.00263372684234	0.428571428571	AP2M1 AP2S1 AP2A2	MHC class II antigen presentation
KEGG:05016	0.00287377243439	0.428571428571	AP2M1 AP2S1 AP2A2	Huntington disease
REAC:R-HSA-162909	0.00306414297155	0.428571428571	AP2M1 AP2S1 AP2A2	Host Interactions of HIV factors
REAC:R-HSA-3858494	0.00433767078452	0.428571428571	AP2M1 AP2S1 AP2A2	Beta-catenin independent WNT signaling
GO:0032799	0.00487641079113	0.428571428571	AP2M1 AP2S1 AP2A2	low-density lipoprotein receptor particle metabolic process
KEGG:04144	0.00645172813212	0.428571428571	AP2M1 AP2S1 AP2A2	Endocytosis
GO:0030118	0.00727854676446	0.428571428571	AP2M1 AP2S1 AP2A2	clathrin coat
GO:0050690	0.00822626332948	0.428571428571	AP2M1 AP2S1 AP2A2	regulation of defense response to virus by virus
GO:0030669	0.0115540711621	0.428571428571	AP2M1 AP2S1 AP2A2	clathrin-coated endocytic vesicle membrane
GO:0030119	0.0115540711621	0.428571428571	AP2M1 AP2S1 AP2A2	AP-type membrane coat adaptor complex
GO:0032801	0.0142076090165	0.428571428571	AP2M1 AP2S1 AP2A2	receptor catabolic process
GO:0034383	0.0142076090165	0.428571428571	AP2M1 AP2S1 AP2A2	low-density lipoprotein particle clearance
REAC:R-HSA-162906	0.0185410541022	0.428571428571	AP2M1 AP2S1 AP2A2	HIV Infection
GO:0030276	0.0336257766492	0.428571428571	AP2M1 AP2S1 AP2A2	clathrin binding
GO:0045334	0.0362050681854	0.428571428571	AP2M1 AP2S1 AP2A2	clathrin-coated endocytic vesicle
GO:0034381	0.0447246492298	0.428571428571	AP2M1 AP2S1 AP2A2	plasma lipoprotein particle clearance
REAC:R-HSA-195721	0.0491203268289	0.428571428571	AP2M1 AP2S1 AP2A2	Signaling by WNT
CORUM:3231	0.0499886427319	0.142857142857	STON2	Eps15-stonin2 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
AAK1	AP2M1	1.0	0.949	hein_WMM bioplex (AP2M1) bioplex_WMM youn_WMM gupta_WMM
AP2M1	AP2A2	1.0	0.949	bioplex (AP2M1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM
AP2M1	AP2S1	0.999	0.949	hein_WMM bioplex (AP2M1,AP2S1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM
AP2M1	STON2	0.998	0.938	hein_WMM bioplex (AP2M1) bioplex_WMM youn_WMM gupta_WMM
CCDC32	AP2S1	0.987	0.901	bioplex (AP2S1) bioplex_WMM
AP2A2	AP2S1	0.971	0.883	bioplex (AP2S1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM
FCHO2	AP2M1	0.919	0.841	hein_WMM bioplex (AP2M1) bioplex_WMM youn_WMM gupta_WMM
AAK1	AP2S1	0.776	0.752	hein_WMM bioplex (AP2S1) bioplex_WMM youn_WMM
AP2S1	STON2	0.657	0.696	hein_WMM bioplex (AP2S1) bioplex_WMM youn_WMM
FCHO2	AP2S1	0.625	0.678	hein_WMM bioplex (AP2S1) bioplex_WMM gupta_WMM
FCHO2	STON2	0.012	0.15	hein_WMM bioplex_WMM WMM_only
AAK1	AP2A2	0.011	0.143	bioplex_WMM youn_WMM gupta_WMM WMM_only
FCHO2	AP2A2	0.01	0.13	bioplex_WMM youn_WMM gupta_WMM WMM_only
AP2A2	STON2	0.01	0.12	bioplex_WMM youn_WMM WMM_only
FCHO2	AAK1	0.01	0.116	hein_WMM bioplex_WMM gupta_WMM WMM_only
AAK1	STON2	0.01	0.097	hein_WMM bioplex_WMM gupta_WMM WMM_only
CCDC32	AP2A2	0.009	0.097	bioplex_WMM WMM_only
CCDC32	AP2M1	0.008	0.081	bioplex_WMM WMM_only
CCDC32	AAK1	0.008	0.046	bioplex_WMM WMM_only
FCHO2	CCDC32	0.008	0.04	bioplex_WMM WMM_only
CCDC32	STON2	0.008	0.034	bioplex_WMM WMM_only

Images

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Complex HuMAP2_03002 has an average edge precision of 0.457 which is ranked 2823 out of all 6965 complexes.

Related Complexes

Genename	Complexes
AP2A2	HuMAP2_01005 HuMAP2_02595 HuMAP2_03002 HuMAP2_03623 HuMAP2_04081 HuMAP2_06613 HuMAP2_06848
AP2S1	HuMAP2_02111 HuMAP2_02595 HuMAP2_03002 HuMAP2_04081 HuMAP2_06613 HuMAP2_06626 HuMAP2_06848
AP2M1	HuMAP2_01005 HuMAP2_01114 HuMAP2_03002 HuMAP2_03989 HuMAP2_06613 HuMAP2_06848
STON2	HuMAP2_02565 HuMAP2_02595 HuMAP2_03002 HuMAP2_06613 HuMAP2_06848
AAK1	HuMAP2_00998 HuMAP2_01005 HuMAP2_01114 HuMAP2_02595 HuMAP2_03002 HuMAP2_06069 HuMAP2_06613
CCDC32	HuMAP2_00989 HuMAP2_02111 HuMAP2_02595 HuMAP2_03002 HuMAP2_04081 HuMAP2_06613 HuMAP2_06626
FCHO2	HuMAP2_00137 HuMAP2_00532 HuMAP2_01298 HuMAP2_03002 HuMAP2_04526

hu.MAP 2.0: Complex View

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Complex: HuMAP2_03002