hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03004
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SAE1 | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | UniProt NCBI |
| UBA2 | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | UniProt NCBI |
| EEF1AKNMT | eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5756 | 3.35600554376e-06 | 0.666666666667 | UBA2 SAE1 | SUA1-UBA2 complex |
| CORUM:5755 | 1.00675659188e-05 | 0.666666666667 | UBA2 SAE1 | SUMO1-SUA1-UBA2 complex |
| REAC:R-HSA-3065676 | 6.69449800487e-05 | 0.666666666667 | UBA2 SAE1 | SUMO is conjugated to E1 (UBA2:SAE1) |
| REAC:R-HSA-3065678 | 0.000140571869389 | 0.666666666667 | UBA2 SAE1 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| REAC:R-HSA-3215018 | 0.000301184970683 | 0.666666666667 | UBA2 SAE1 | Processing and activation of SUMO |
| GO:0019948 | 0.00135247023414 | 0.666666666667 | UBA2 SAE1 | SUMO activating enzyme activity |
| KEGG:04120 | 0.00373360278335 | 0.666666666667 | UBA2 SAE1 | Ubiquitin mediated proteolysis |
| GO:0031510 | 0.00405722906526 | 0.666666666667 | UBA2 SAE1 | SUMO activating enzyme complex |
| GO:0044388 | 0.0135228859698 | 0.666666666667 | UBA2 SAE1 | small protein activating enzyme binding |
| GO:0008641 | 0.0486736709081 | 0.666666666667 | UBA2 SAE1 | ubiquitin-like modifier activating enzyme activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SAE1 | UBA2 | 0.988 | 0.901 | hein_WMM bioplex (UBA2) bioplex_WMM Guru youn_WMM hein (SAE1) gupta_WMM fraction |
| SAE1 | EEF1AKNMT | 0.179 | 0.438 | bioplex_WMM fraction |
| EEF1AKNMT | UBA2 | 0.004 | 0.012 | fraction |
Images
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Complex HuMAP2_03004 has an average edge precision of 0.45 which is ranked 2870 out of all 6965 complexes.
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