hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03006
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CAMKMT | Calmodulin-lysine N-methyltransferase (CLNMT) (CaM KMT) (EC 2.1.1.60) | UniProt NCBI |
| ERAL1 | GTPase Era, mitochondrial (H-ERA) (hERA) (Conserved ERA-like GTPase) (CEGA) (ERA-W) (ERA-like protein 1) | UniProt NCBI |
| COL1A2 | Collagen alpha-2(I) chain (Alpha-2 type I collagen) | UniProt NCBI |
| COL3A1 | Collagen alpha-1(III) chain | UniProt NCBI |
| COL1A1 | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP453 | 8.93109592424e-07 | 0.6 | COL1A2 COL1A1 COL3A1 | Inflammatory Response Pathway |
| REAC:R-HSA-3000480 | 1.84639431008e-06 | 0.6 | COL1A2 COL1A1 COL3A1 | Scavenging by Class A Receptors |
| REAC:R-HSA-3000170 | 7.0533398358e-06 | 0.6 | COL1A2 COL1A1 COL3A1 | Syndecan interactions |
| REAC:R-HSA-8874081 | 8.88541585136e-06 | 0.6 | COL1A2 COL1A1 COL3A1 | MET activates PTK2 signaling |
| HP:0001075 | 1.65480236581e-05 | 0.6 | COL1A2 COL1A1 COL3A1 | Atrophic scars |
| REAC:R-HSA-2173782 | 1.77393158174e-05 | 0.6 | COL1A2 COL1A1 COL3A1 | Binding and Uptake of Ligands by Scavenger Receptors |
| REAC:R-HSA-8875878 | 2.10552596086e-05 | 0.6 | COL1A2 COL1A1 COL3A1 | MET promotes cell motility |
| REAC:R-HSA-8948216 | 2.47599987196e-05 | 0.6 | COL1A2 COL1A1 COL3A1 | Collagen chain trimerization |
| HP:0005897 | 4.64766403483e-05 | 0.4 | COL1A2 COL1A1 | Severe generalized osteoporosis |
| HP:0003321 | 4.64766403483e-05 | 0.4 | COL1A2 COL1A1 | Biconcave flattened vertebrae |
| HP:0005005 | 4.64766403483e-05 | 0.4 | COL1A2 COL1A1 | Femoral bowing present at birth, straightening with time |
| HP:0005623 | 4.64766403483e-05 | 0.4 | COL1A2 COL1A1 | Absent ossification of calvaria |
| KEGG:04974 | 5.79822076286e-05 | 0.6 | COL1A2 COL1A1 COL3A1 | Protein digestion and absorption |
| REAC:R-HSA-2022090 | 7.49721357414e-05 | 0.6 | COL1A2 COL1A1 COL3A1 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-3000171 | 7.91292628349e-05 | 0.6 | COL1A2 COL1A1 COL3A1 | Non-integrin membrane-ECM interactions |
| KEGG:05146 | 8.47258888416e-05 | 0.6 | COL1A2 COL1A1 COL3A1 | Amoebiasis |
| REAC:R-HSA-1442490 | 9.25148000407e-05 | 0.6 | COL1A2 COL1A1 COL3A1 | Collagen degradation |
| REAC:R-HSA-1650814 | 0.00010222685444 | 0.6 | COL1A2 COL1A1 COL3A1 | Collagen biosynthesis and modifying enzymes |
| KEGG:04933 | 0.000104147822452 | 0.6 | COL1A2 COL1A1 COL3A1 | AGE-RAGE signaling pathway in diabetic complications |
| REAC:R-HSA-3000178 | 0.000123638575202 | 0.6 | COL1A2 COL1A1 COL3A1 | ECM proteoglycans |
| GO:0098643 | 0.000149729915117 | 0.6 | COL1A2 COL1A1 COL3A1 | banded collagen fibril |
| GO:0005583 | 0.000149729915117 | 0.6 | COL1A2 COL1A1 COL3A1 | fibrillar collagen trimer |
| GO:0048407 | 0.000149729915117 | 0.6 | COL1A2 COL1A1 COL3A1 | platelet-derived growth factor binding |
| REAC:R-HSA-6806834 | 0.000167928044622 | 0.6 | COL1A2 COL1A1 COL3A1 | Signaling by MET |
| REAC:R-HSA-216083 | 0.00018227939524 | 0.6 | COL1A2 COL1A1 COL3A1 | Integrin cell surface interactions |
| KEGG:04611 | 0.000189775187446 | 0.6 | COL1A2 COL1A1 COL3A1 | Platelet activation |
| REAC:R-HSA-198933 | 0.00023017619861 | 0.6 | COL1A2 COL1A1 COL3A1 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| KEGG:04926 | 0.000240055495634 | 0.6 | COL1A2 COL1A1 COL3A1 | Relaxin signaling pathway |
| REAC:R-HSA-1474290 | 0.00025697910325 | 0.6 | COL1A2 COL1A1 COL3A1 | Collagen formation |
| HP:0003023 | 0.000278784943944 | 0.4 | COL1A2 COL1A1 | Bowing of limbs due to multiple fractures |
| HP:0000444 | 0.000287298458388 | 0.6 | COL1A2 COL1A1 COL3A1 | Convex nasal ridge |
| REAC:R-HSA-430116 | 0.000377631329325 | 0.4 | COL1A2 COL1A1 | GP1b-IX-V activation signalling |
| WP:WP3967 | 0.000399978956636 | 0.4 | COL3A1 COL1A1 | miR-509-3p alteration of YAP1/ECM axis |
| HP:0000592 | 0.000445635390561 | 0.6 | COL1A2 COL1A1 COL3A1 | Blue sclerae |
| HP:0004334 | 0.000445635390561 | 0.6 | COL1A2 COL1A1 COL3A1 | Dermal atrophy |
| HP:0005758 | 0.00046457916755 | 0.4 | COL1A2 COL1A1 | Basilar impression |
| HP:0000362 | 0.00046457916755 | 0.4 | COL1A2 COL1A1 | Otosclerosis |
| HP:0001634 | 0.000466156074572 | 0.6 | COL1A2 COL1A1 COL3A1 | Mitral valve prolapse |
| HP:0000963 | 0.000466156074572 | 0.6 | COL1A2 COL1A1 COL3A1 | Thin skin |
| REAC:R-HSA-75892 | 0.000485460775426 | 0.4 | COL1A2 COL1A1 | Platelet Adhesion to exposed collagen |
| HP:0000923 | 0.000696775152219 | 0.4 | COL1A2 COL1A1 | Beaded ribs |
| HP:0100823 | 0.000696775152219 | 0.4 | COL3A1 COL1A1 | Genital hernia |
| HP:0006367 | 0.000696775152219 | 0.4 | COL1A2 COL1A1 | Crumpled long bones |
| WP:WP2911 | 0.000699493021643 | 0.4 | COL1A2 COL3A1 | miRNA targets in ECM and membrane receptors |
| HP:0001633 | 0.000734739321212 | 0.6 | COL1A2 COL1A1 COL3A1 | Abnormal mitral valve morphology |
| GO:0098644 | 0.000739960245213 | 0.6 | COL1A2 COL1A1 COL3A1 | complex of collagen trimers |
| HP:0000591 | 0.00079256546738 | 0.6 | COL1A2 COL1A1 COL3A1 | Abnormal sclera morphology |
| REAC:R-HSA-1474228 | 0.000916592958714 | 0.6 | COL1A2 COL1A1 COL3A1 | Degradation of the extracellular matrix |
| HP:0000703 | 0.00097535418756 | 0.4 | COL1A2 COL1A1 | Dentinogenesis imperfecta |
| HP:0005294 | 0.00130029756695 | 0.4 | COL3A1 COL1A1 | Arterial dissection |
| HP:0008628 | 0.00130029756695 | 0.4 | COL1A2 COL1A1 | Abnormality of the stapes |
| HP:0010299 | 0.00130029756695 | 0.4 | COL1A2 COL1A1 | Abnormality of dentin |
| HP:0006705 | 0.00141044232307 | 0.6 | COL1A2 COL1A1 COL3A1 | Abnormal atrioventricular valve morphology |
| REAC:R-HSA-2214320 | 0.00141478632427 | 0.4 | COL1A2 COL1A1 | Anchoring fibril formation |
| HP:0008921 | 0.00167158658755 | 0.4 | COL1A2 COL1A1 | Neonatal short-limb short stature |
| WP:WP3932 | 0.00181204447901 | 0.6 | COL1A2 COL1A1 COL3A1 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| HP:0001622 | 0.00189129875245 | 0.6 | COL1A2 COL1A1 COL3A1 | Premature birth |
| HP:0008067 | 0.00194462919809 | 0.6 | COL1A2 COL1A1 COL3A1 | Abnormally lax or hyperextensible skin |
| HP:0000987 | 0.00205426749297 | 0.6 | COL1A2 COL1A1 COL3A1 | Atypical scarring of skin |
| REAC:R-HSA-2243919 | 0.00206071490935 | 0.4 | COL1A2 COL1A1 | Crosslinking of collagen fibrils |
| HP:0003179 | 0.00208920255027 | 0.4 | COL1A2 COL1A1 | Protrusio acetabuli |
| HP:0005474 | 0.00208920255027 | 0.4 | COL1A2 COL1A1 | Decreased calvarial ossification |
| HP:0000978 | 0.00211059325497 | 0.6 | COL1A2 COL1A1 COL3A1 | Bruising susceptibility |
| HP:0010547 | 0.0030633405246 | 0.4 | COL1A2 COL1A1 | Muscle flaccidity |
| HP:0004452 | 0.0030633405246 | 0.4 | COL1A2 COL1A1 | Abnormality of the middle ear ossicles |
| HP:0100699 | 0.00308244473231 | 0.6 | COL1A2 COL1A1 COL3A1 | Scarring |
| HP:0040160 | 0.00361982515692 | 0.4 | COL1A2 COL1A1 | Generalized osteoporosis |
| GO:0005581 | 0.00367721278555 | 0.6 | COL1A2 COL1A1 COL3A1 | collagen trimer |
| HP:0002691 | 0.00422256197273 | 0.4 | COL1A2 COL1A1 | Platybasia |
| HP:0001790 | 0.00422256197273 | 0.4 | COL1A2 COL1A1 | Nonimmune hydrops fetalis |
| HP:0005855 | 0.00422256197273 | 0.4 | COL1A2 COL1A1 | Multiple prenatal fractures |
| GO:0005584 | 0.00450823411379 | 0.4 | COL1A2 COL1A1 | collagen type I trimer |
| HP:0008065 | 0.00459288028975 | 0.6 | COL1A2 COL1A1 COL3A1 | Aplasia/Hypoplasia of the skin |
| HP:0008609 | 0.00487153229182 | 0.4 | COL1A2 COL1A1 | Morphological abnormality of the middle ear |
| HP:0010647 | 0.00498434077123 | 0.6 | COL1A2 COL1A1 COL3A1 | Abnormal elasticity of skin |
| REAC:R-HSA-114604 | 0.00508433997358 | 0.4 | COL1A2 COL1A1 | GPVI-mediated activation cascade |
| GO:0030199 | 0.00541762673764 | 0.6 | COL1A2 COL1A1 COL3A1 | collagen fibril organization |
| HP:0004970 | 0.00556671743772 | 0.4 | COL3A1 COL1A1 | Ascending tubular aorta aneurysm |
| REAC:R-HSA-76009 | 0.00584945327803 | 0.4 | COL1A2 COL1A1 | Platelet Aggregation (Plug Formation) |
| HP:0005743 | 0.00630809873773 | 0.4 | COL1A2 COL1A1 | Avascular necrosis of the capital femoral epiphysis |
| HP:0100541 | 0.00630809873773 | 0.4 | COL1A2 COL1A1 | Femoral hernia |
| HP:0000015 | 0.00630809873773 | 0.4 | COL1A2 COL3A1 | Bladder diverticulum |
| HP:0004586 | 0.00630809873773 | 0.4 | COL1A2 COL1A1 | Biconcave vertebral bodies |
| GO:0030020 | 0.00646290954968 | 0.6 | COL1A2 COL1A1 COL3A1 | extracellular matrix structural constituent conferring tensile strength |
| HP:0005692 | 0.00702033217347 | 0.6 | COL1A2 COL1A1 COL3A1 | Joint hyperflexibility |
| GO:0044420 | 0.00703245670927 | 0.6 | COL1A2 COL1A1 COL3A1 | extracellular matrix component |
| HP:0010444 | 0.00709565752293 | 0.4 | COL1A2 COL1A1 | Pulmonary insufficiency |
| HP:0001623 | 0.00709565752293 | 0.4 | COL1A2 COL1A1 | Breech presentation |
| HP:0009124 | 0.00780468270807 | 0.6 | COL1A2 COL1A1 COL3A1 | Abnormal adipose tissue morphology |
| HP:0001197 | 0.0079005654453 | 0.8 | COL1A2 COL1A1 CAMKMT COL3A1 | Abnormality of prenatal development or birth |
| REAC:R-HSA-1474244 | 0.00830412575866 | 0.6 | COL1A2 COL1A1 COL3A1 | Extracellular matrix organization |
| HP:0011119 | 0.00879065778809 | 0.6 | COL1A2 COL1A1 COL3A1 | Abnormality of the nasal dorsum |
| HP:0002827 | 0.00923728902624 | 0.6 | COL1A2 COL1A1 COL3A1 | Hip dislocation |
| HP:0001933 | 0.00923728902624 | 0.6 | COL1A2 COL1A1 COL3A1 | Subcutaneous hemorrhage |
| HP:0000023 | 0.00985583118217 | 0.6 | COL1A2 COL1A1 COL3A1 | Inguinal hernia |
| HP:0001030 | 0.0107072942689 | 0.4 | COL1A2 COL3A1 | Fragile skin |
| HP:0000278 | 0.0113465056889 | 0.6 | COL1A2 COL1A1 COL3A1 | Retrognathia |
| MIRNA:hsa-miR-29c-3p | 0.0115508476381 | 0.6 | COL1A2 COL1A1 COL3A1 | hsa-miR-29c-3p |
| HP:0000977 | 0.011725460578 | 0.4 | COL1A2 COL1A1 | Soft skin |
| HP:0002982 | 0.011725460578 | 0.4 | COL1A2 COL1A1 | Tibial bowing |
| KEGG:04512 | 0.0127624438559 | 0.4 | COL1A2 COL1A1 | ECM-receptor interaction |
| HP:0100323 | 0.0127896924378 | 0.4 | COL1A2 COL1A1 | Juvenile aseptic necrosis |
| WP:WP615 | 0.0129250833235 | 0.4 | COL3A1 COL1A1 | Senescence and Autophagy in Cancer |
| HP:0000422 | 0.0134266053844 | 0.8 | COL1A2 COL1A1 CAMKMT COL3A1 | Abnormality of the nasal bridge |
| GO:0043589 | 0.0135228859698 | 0.4 | COL1A2 COL1A1 | skin morphogenesis |
| HP:0002107 | 0.0138999712057 | 0.4 | COL3A1 COL1A1 | Pneumothorax |
| HP:0000119 | 0.0146823604681 | 1.0 | COL1A2 COL3A1 CAMKMT COL1A1 ERAL1 | Abnormality of the genitourinary system |
| HP:0001654 | 0.0147605976923 | 0.6 | COL1A2 COL1A1 COL3A1 | Abnormal heart valve morphology |
| HP:0030311 | 0.0153884218008 | 0.6 | COL1A2 COL1A1 COL3A1 | Lower extremity joint dislocation |
| HP:0004331 | 0.0188011826397 | 0.4 | COL1A2 COL1A1 | Decreased skull ossification |
| HP:0001384 | 0.0190366563871 | 0.6 | COL1A2 COL1A1 COL3A1 | Abnormality of the hip joint |
| HP:0001382 | 0.0192819219746 | 0.6 | COL1A2 COL1A1 COL3A1 | Joint hypermobility |
| HP:0005262 | 0.0207975055827 | 0.6 | COL1A2 COL1A1 COL3A1 | Abnormality of the synovia |
| HP:0011061 | 0.0215839586173 | 0.6 | COL1A2 COL1A1 COL3A1 | Abnormality of dental structure |
| HP:0003100 | 0.0229596708254 | 0.4 | COL1A2 COL1A1 | Slender long bone |
| HP:0010318 | 0.0244376541782 | 0.4 | COL3A1 COL1A1 | Aplasia/Hypoplasia of the abdominal wall musculature |
| HP:0002980 | 0.0259615168254 | 0.4 | COL1A2 COL1A1 | Femoral bowing |
| HP:0010529 | 0.0259615168254 | 0.4 | COL1A2 COL1A1 | Echolalia |
| HP:0002703 | 0.0275312401623 | 0.4 | COL1A2 COL1A1 | Abnormality of skull ossification |
| REAC:R-HSA-9006934 | 0.0291077226575 | 0.6 | COL1A2 COL1A1 COL3A1 | Signaling by Receptor Tyrosine Kinases |
| HP:0005293 | 0.0291468055875 | 0.4 | COL3A1 COL1A1 | Venous insufficiency |
| HP:0000492 | 0.0300073830984 | 0.8 | COL1A2 COL1A1 CAMKMT COL3A1 | Abnormal eyelid morphology |
| HP:0002300 | 0.0325153883173 | 0.4 | COL1A2 COL1A1 | Mutism |
| HP:0011218 | 0.0336572505221 | 0.6 | COL1A2 CAMKMT COL1A1 | Abnormal shape of the frontal region |
| HP:0002007 | 0.0336572505221 | 0.6 | COL1A2 CAMKMT COL1A1 | Frontal bossing |
| HP:0001373 | 0.0354679667682 | 0.6 | COL1A2 COL1A1 COL3A1 | Joint dislocation |
| HP:0025487 | 0.0360671162807 | 0.4 | COL1A2 COL3A1 | Abnormality of bladder morphology |
| HP:0001001 | 0.0379116132621 | 0.4 | COL1A2 COL1A1 | Abnormality of subcutaneous fat tissue |
| HP:0002812 | 0.0379116132621 | 0.4 | COL1A2 COL1A1 | Coxa vara |
| HP:0002645 | 0.0398018408038 | 0.4 | COL1A2 COL1A1 | Wormian bones |
| HP:0010574 | 0.0398018408038 | 0.4 | COL1A2 COL1A1 | Abnormality of the epiphysis of the femoral head |
| HP:0000974 | 0.0437194132729 | 0.4 | COL1A2 COL1A1 | Hyperextensible skin |
| HP:0006499 | 0.0437194132729 | 0.4 | COL1A2 COL1A1 | Abnormality of femoral epiphysis |
| HP:0006500 | 0.0457467210618 | 0.4 | COL1A2 COL1A1 | Abnormality of lower limb epiphysis morphology |
| HP:0010991 | 0.0457467210618 | 0.4 | COL3A1 COL1A1 | Abnormal morphology of the abdominal musculature |
| HP:0002758 | 0.0478196851342 | 0.4 | COL3A1 COL1A1 | Osteoarthritis |
| HP:0002381 | 0.0478196851342 | 0.4 | COL1A2 COL1A1 | Aphasia |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| COL1A2 | CAMKMT | 0.775 | 0.752 | bioplex (CAMKMT) bioplex_WMM |
| COL1A2 | ERAL1 | 0.588 | 0.662 | bioplex (ERAL1) bioplex_WMM |
| COL1A1 | ERAL1 | 0.081 | 0.351 | bioplex (ERAL1) bioplex_WMM |
| COL1A1 | CAMKMT | 0.072 | 0.353 | bioplex (CAMKMT) bioplex_WMM |
| COL3A1 | ERAL1 | 0.071 | 0.353 | bioplex (ERAL1) bioplex_WMM |
| COL1A2 | COL1A1 | 0.014 | 0.144 | bioplex_WMM boldt boldt_WMM treiber_WMM |
| COL1A2 | COL3A1 | 0.01 | 0.099 | bioplex_WMM WMM_only |
| COL3A1 | COL1A1 | 0.009 | 0.111 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_03006 has an average edge precision of 0.353 which is ranked 3886 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CAMKMT | HuMAP2_00097 HuMAP2_00824 HuMAP2_02515 HuMAP2_03006 HuMAP2_04189 |
| ERAL1 | HuMAP2_00097 HuMAP2_02515 HuMAP2_03006 HuMAP2_03686 HuMAP2_03923 |
| COL1A2 | HuMAP2_00097 HuMAP2_00824 HuMAP2_02515 HuMAP2_03006 HuMAP2_04189 |
| COL3A1 | HuMAP2_00097 HuMAP2_03006 HuMAP2_04189 |
| COL1A1 | HuMAP2_00097 HuMAP2_03006 HuMAP2_04189 |