hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03015
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PBK | Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) | UniProt NCBI |
| DAG1 | Dystroglycan (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] | UniProt NCBI |
| LGALS9B | Galectin-9B (Gal-9B) (Galectin-9-like protein A) | UniProt NCBI |
| LGALS9 | Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21) | UniProt NCBI |
| LGALS9C | Galectin-9C (Gal-9C) (Galectin-9-like protein B) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016936 | 9.08185760231e-07 | 0.6 | LGALS9B LGALS9 LGALS9C | galactoside binding |
| GO:2001181 | 1.81582264982e-05 | 0.6 | LGALS9B LGALS9 LGALS9C | positive regulation of interleukin-10 secretion |
| GO:2000562 | 1.81582264982e-05 | 0.6 | LGALS9B LGALS9 LGALS9C | negative regulation of CD4-positive, alpha-beta T cell proliferation |
| GO:2001179 | 3.17736949706e-05 | 0.6 | LGALS9B LGALS9 LGALS9C | regulation of interleukin-10 secretion |
| GO:0046642 | 5.0832789986e-05 | 0.6 | LGALS9B LGALS9 LGALS9C | negative regulation of alpha-beta T cell proliferation |
| GO:2000561 | 7.62415024416e-05 | 0.6 | LGALS9B LGALS9 LGALS9C | regulation of CD4-positive, alpha-beta T cell proliferation |
| GO:0072608 | 7.62415024416e-05 | 0.6 | LGALS9B LGALS9 LGALS9C | interleukin-10 secretion |
| GO:0035739 | 7.62415024416e-05 | 0.6 | LGALS9B LGALS9 LGALS9C | CD4-positive, alpha-beta T cell proliferation |
| GO:0032733 | 0.000616695699567 | 0.6 | LGALS9B LGALS9 LGALS9C | positive regulation of interleukin-10 production |
| GO:2000515 | 0.000739960245213 | 0.6 | LGALS9B LGALS9 LGALS9C | negative regulation of CD4-positive, alpha-beta T cell activation |
| GO:0046633 | 0.000878614215261 | 0.6 | LGALS9B LGALS9 LGALS9C | alpha-beta T cell proliferation |
| GO:0046640 | 0.000878614215261 | 0.6 | LGALS9B LGALS9 LGALS9C | regulation of alpha-beta T cell proliferation |
| GO:0032689 | 0.00103355958129 | 0.6 | LGALS9B LGALS9 LGALS9C | negative regulation of interferon-gamma production |
| GO:2000778 | 0.00139593056214 | 0.6 | LGALS9B LGALS9 LGALS9C | positive regulation of interleukin-6 secretion |
| GO:0046636 | 0.00139593056214 | 0.6 | LGALS9B LGALS9 LGALS9C | negative regulation of alpha-beta T cell activation |
| GO:0032653 | 0.00265002518516 | 0.6 | LGALS9B LGALS9 LGALS9C | regulation of interleukin-10 production |
| WP:WP3945 | 0.00272401961957 | 0.4 | LGALS9B LGALS9C | TYROBP Causal Network |
| GO:0042130 | 0.00296772889435 | 0.6 | LGALS9B LGALS9 LGALS9C | negative regulation of T cell proliferation |
| GO:0032613 | 0.00367721278555 | 0.6 | LGALS9B LGALS9 LGALS9C | interleukin-10 production |
| GO:0072604 | 0.00407078924856 | 0.6 | LGALS9B LGALS9 LGALS9C | interleukin-6 secretion |
| GO:0050672 | 0.0049400991777 | 0.6 | LGALS9B LGALS9 LGALS9C | negative regulation of lymphocyte proliferation |
| GO:0032945 | 0.0049400991777 | 0.6 | LGALS9B LGALS9 LGALS9C | negative regulation of mononuclear cell proliferation |
| GO:0070664 | 0.00646290954968 | 0.6 | LGALS9B LGALS9 LGALS9C | negative regulation of leukocyte proliferation |
| GO:2000514 | 0.00763446836913 | 0.6 | LGALS9B LGALS9 LGALS9C | regulation of CD4-positive, alpha-beta T cell activation |
| GO:0046634 | 0.0177162705742 | 0.6 | LGALS9B LGALS9 LGALS9C | regulation of alpha-beta T cell activation |
| GO:0035710 | 0.0199719657189 | 0.6 | LGALS9B LGALS9 LGALS9C | CD4-positive, alpha-beta T cell activation |
| GO:0032649 | 0.0211681462149 | 0.6 | LGALS9B LGALS9 LGALS9C | regulation of interferon-gamma production |
| GO:0032755 | 0.0237016209836 | 0.6 | LGALS9B LGALS9 LGALS9C | positive regulation of interleukin-6 production |
| GO:0050868 | 0.0250406933376 | 0.6 | LGALS9B LGALS9 LGALS9C | negative regulation of T cell activation |
| GO:0032609 | 0.0278679504637 | 0.6 | LGALS9B LGALS9 LGALS9C | interferon-gamma production |
| GO:1903038 | 0.0394222084305 | 0.6 | LGALS9B LGALS9 LGALS9C | negative regulation of leukocyte cell-cell adhesion |
| GO:0046631 | 0.0452171392335 | 0.6 | LGALS9B LGALS9 LGALS9C | alpha-beta T cell activation |
| GO:0051250 | 0.0493791608738 | 0.6 | LGALS9B LGALS9 LGALS9C | negative regulation of lymphocyte activation |
| CORUM:422 | 0.0499494897235 | 0.2 | DAG1 | Beta-dystroglycan-caveolin-3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LGALS9B | LGALS9 | 1.0 | 0.949 | bioplex (LGALS9) bioplex_WMM |
| PBK | LGALS9 | 0.984 | 0.899 | bioplex (PBK) bioplex_WMM |
| DAG1 | LGALS9 | 0.92 | 0.844 | bioplex (LGALS9) bioplex_WMM |
| LGALS9 | LGALS9C | 0.912 | 0.835 | bioplex (LGALS9C) bioplex_WMM |
| DAG1 | LGALS9B | 0.008 | 0.022 | bioplex_WMM WMM_only |
| DAG1 | LGALS9C | 0.005 | 0.01 | bioplex (LGALS9C) bioplex_WMM |
| PBK | LGALS9B | 0.0 | 0.003 | bioplex (PBK) bioplex_WMM |
Images
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Complex HuMAP2_03015 has an average edge precision of 0.509 which is ranked 2454 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PBK | HuMAP2_03015 HuMAP2_05221 |
| DAG1 | HuMAP2_03015 HuMAP2_05221 |
| LGALS9B | HuMAP2_03015 HuMAP2_05221 |
| LGALS9 | HuMAP2_03015 HuMAP2_05221 |
| LGALS9C | HuMAP2_03015 HuMAP2_05221 |