hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03016
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DICER1 | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) | UniProt NCBI |
| TARBP2 | RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5381 | 5.02777038712e-06 | 1.0 | TARBP2 DICER1 | RNA-induced silencing complex, RISC |
| CORUM:5377 | 5.02777038712e-06 | 1.0 | TARBP2 DICER1 | RNA-induced silencing complex, RISC |
| WP:WP2338 | 5.58871997577e-06 | 1.0 | TARBP2 DICER1 | miRNA Biogenesis |
| CORUM:3032 | 1.00555407742e-05 | 1.0 | TARBP2 DICER1 | RNA-induced silencing complex, RISC |
| CORUM:5378 | 2.51388519356e-05 | 1.0 | TARBP2 DICER1 | TRBP containing complex (DICER, TRBP, AGO2, RPL7A, EIF6, MOV10) |
| REAC:R-HSA-426486 | 6.03332446455e-05 | 1.0 | TARBP2 DICER1 | Small interfering RNA (siRNA) biogenesis |
| REAC:R-HSA-203927 | 0.000462554875615 | 1.0 | TARBP2 DICER1 | MicroRNA (miRNA) biogenesis |
| WP:WP4549 | 0.00244227062941 | 1.0 | TARBP2 DICER1 | Fragile X Syndrome |
| GO:0030423 | 0.00270494046827 | 1.0 | TARBP2 DICER1 | targeting of mRNA for destruction involved in RNA interference |
| GO:0035087 | 0.00270494046827 | 1.0 | TARBP2 DICER1 | siRNA loading onto RISC involved in RNA interference |
| GO:0035197 | 0.00676235117068 | 1.0 | TARBP2 DICER1 | siRNA binding |
| GO:0070883 | 0.00676235117068 | 1.0 | TARBP2 DICER1 | pre-miRNA binding |
| GO:0035280 | 0.00946729163895 | 1.0 | TARBP2 DICER1 | miRNA loading onto RISC involved in gene silencing by miRNA |
| WP:WP2943 | 0.0110973349652 | 0.5 | DICER1 | Hypoxia-mediated EMT and Stemness |
| REAC:R-HSA-211000 | 0.0144900342557 | 1.0 | TARBP2 DICER1 | Gene Silencing by RNA |
| GO:0070922 | 0.0162296428096 | 1.0 | TARBP2 DICER1 | small RNA loading onto RISC |
| GO:0070578 | 0.0162296428096 | 1.0 | TARBP2 DICER1 | RISC-loading complex |
| GO:0030422 | 0.020287053512 | 1.0 | TARBP2 DICER1 | production of siRNA involved in RNA interference |
| WP:WP2805 | 0.0332875339197 | 0.5 | DICER1 | exRNA mechanism of action and biogenesis |
| GO:0031332 | 0.0351642260875 | 1.0 | TARBP2 DICER1 | RNAi effector complex |
| GO:0016442 | 0.0351642260875 | 1.0 | TARBP2 DICER1 | RISC complex |
| GO:0031054 | 0.0473364581948 | 1.0 | TARBP2 DICER1 | pre-miRNA processing |
| GO:0016246 | 0.0473364581948 | 1.0 | TARBP2 DICER1 | RNA interference |
| HP:0000866 | 0.0497341708567 | 0.5 | DICER1 | Euthyroid multinodular goiter |
| HP:0030983 | 0.0497341708567 | 0.5 | DICER1 | Ovarian thecoma |
| HP:0031918 | 0.0497341708567 | 0.5 | DICER1 | Ovarian sex cord-stromal tumor |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DICER1 | TARBP2 | 0.994 | 0.923 | hein_WMM bioplex_WMM boldt youn_WMM hein (DICER1) boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_03016 has an average edge precision of 0.923 which is ranked 461 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DICER1 | HuMAP2_03016 HuMAP2_03926 HuMAP2_06846 |
| TARBP2 | HuMAP2_03016 HuMAP2_03926 HuMAP2_06846 |