hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03018
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AURKA | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A) | UniProt NCBI |
| MTMR3 | Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) (Zinc finger FYVE domain-containing protein 10) | UniProt NCBI |
| MTMR4 | Myotubularin-related protein 4 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Zinc finger FYVE domain-containing protein 11) | UniProt NCBI |
| SNX18 | Sorting nexin-18 (SH3 and PX domain-containing protein 3B) (Sorting nexin-associated Golgi protein 1) | UniProt NCBI |
| ITPKC | Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase C) (IP3 3-kinase C) (IP3K C) (InsP 3-kinase C) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00562 | 4.90975651011e-05 | 0.6 | MTMR3 ITPKC MTMR4 | Inositol phosphate metabolism |
| KEGG:04070 | 0.00010764753353 | 0.6 | MTMR3 ITPKC MTMR4 | Phosphatidylinositol signaling system |
| WP:WP1984 | 0.0337317416567 | 0.4 | AURKA ITPKC | Integrated Breast Cancer Pathway |
| KEGG:04140 | 0.0370300962025 | 0.4 | MTMR3 MTMR4 | Autophagy - animal |
| REAC:R-HSA-1483255 | 0.0401214552357 | 0.4 | MTMR3 MTMR4 | PI Metabolism |
| GO:0060304 | 0.0450641792523 | 0.4 | MTMR3 MTMR4 | regulation of phosphatidylinositol dephosphorylation |
| CORUM:6412 | 0.0499494897235 | 0.2 | AURKA | AURKA-HDAC6 cilia-disassembly complex |
| CORUM:6740 | 0.0499494897235 | 0.2 | AURKA | AURKA-INPP5E complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AURKA | SNX18 | 0.314 | 0.508 | bioplex (AURKA) bioplex_WMM |
| ITPKC | AURKA | 0.23 | 0.468 | bioplex (AURKA) bioplex_WMM |
| AURKA | MTMR3 | 0.171 | 0.43 | bioplex (AURKA) bioplex_WMM youn_WMM |
| AURKA | MTMR4 | 0.062 | 0.344 | bioplex (AURKA) bioplex_WMM |
| MTMR3 | MTMR4 | 0.015 | 0.152 | bioplex_WMM WMM_only |
| ITPKC | SNX18 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| ITPKC | MTMR4 | 0.008 | 0.07 | bioplex_WMM WMM_only |
| ITPKC | MTMR3 | 0.008 | 0.033 | bioplex_WMM WMM_only |
| MTMR4 | SNX18 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| MTMR3 | SNX18 | 0.007 | 0.006 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_03018 has an average edge precision of 0.21 which is ranked 6033 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AURKA | HuMAP2_02352 HuMAP2_03018 HuMAP2_06553 |
| MTMR3 | HuMAP2_02352 HuMAP2_03018 |
| MTMR4 | HuMAP2_02352 HuMAP2_03018 HuMAP2_05088 |
| SNX18 | HuMAP2_02352 HuMAP2_03018 HuMAP2_03175 |
| ITPKC | HuMAP2_00194 HuMAP2_02352 HuMAP2_03018 |