hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03022
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NCKAP5L | Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169) | UniProt NCBI |
| EXOC4 | Exocyst complex component 4 (Exocyst complex component Sec8) | UniProt NCBI |
| EXOC1 | Exocyst complex component 1 (Exocyst complex component Sec3) | UniProt NCBI |
| EXOC6B | Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2) | UniProt NCBI |
| EXOC6 | Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1) | UniProt NCBI |
| EXOC2 | Exocyst complex component 2 (Exocyst complex component Sec5) | UniProt NCBI |
| EXOC5 | Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10) | UniProt NCBI |
| EXOC7 | Exocyst complex component 7 (Exocyst complex component Exo70) | UniProt NCBI |
| EXOC3 | Exocyst complex component 3 (Exocyst complex component Sec6) | UniProt NCBI |
| IL1R2 | Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)] | UniProt NCBI |
| DIP2B | Disco-interacting protein 2 homolog B (DIP2 homolog B) | UniProt NCBI |
| EXOC8 | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6167 | 5.12255321314e-25 | 0.666666666667 | EXOC7 EXOC5 EXOC6 EXOC3 EXOC8 EXOC1 EXOC4 EXOC2 | Exocyst complex |
| CORUM:89 | 5.12255321314e-25 | 0.666666666667 | EXOC7 EXOC5 EXOC6 EXOC3 EXOC8 EXOC1 EXOC4 EXOC2 | Exocyst Sec6/8 complex |
| REAC:R-HSA-5620916 | 1.50358517696e-19 | 0.666666666667 | EXOC7 EXOC5 EXOC6 EXOC3 EXOC8 EXOC1 EXOC4 EXOC2 | VxPx cargo-targeting to cilium |
| GO:0000145 | 5.30739345401e-19 | 0.666666666667 | EXOC3 EXOC5 EXOC6 EXOC6B EXOC8 EXOC1 EXOC4 EXOC2 | exocyst |
| REAC:R-HSA-264876 | 1.46135623797e-18 | 0.666666666667 | EXOC7 EXOC5 EXOC6 EXOC3 EXOC8 EXOC1 EXOC4 EXOC2 | Insulin processing |
| REAC:R-HSA-5620920 | 6.21387710574e-16 | 0.666666666667 | EXOC7 EXOC5 EXOC6 EXOC3 EXOC8 EXOC1 EXOC4 EXOC2 | Cargo trafficking to the periciliary membrane |
| REAC:R-HSA-1445148 | 1.45337756294e-14 | 0.666666666667 | EXOC7 EXOC5 EXOC6 EXOC3 EXOC8 EXOC1 EXOC4 EXOC2 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-2980736 | 1.64359042844e-14 | 0.666666666667 | EXOC7 EXOC5 EXOC6 EXOC3 EXOC8 EXOC1 EXOC4 EXOC2 | Peptide hormone metabolism |
| WP:WP4352 | 2.88755886737e-13 | 0.75 | EXOC7 EXOC5 EXOC6 EXOC6B EXOC3 EXOC8 EXOC1 EXOC4 EXOC2 | Ciliary landscape |
| GO:0099023 | 5.79795000913e-13 | 0.666666666667 | EXOC3 EXOC5 EXOC6 EXOC6B EXOC8 EXOC1 EXOC4 EXOC2 | vesicle tethering complex |
| REAC:R-HSA-5617833 | 7.22763375935e-11 | 0.666666666667 | EXOC7 EXOC5 EXOC6 EXOC3 EXOC8 EXOC1 EXOC4 EXOC2 | Cilium Assembly |
| GO:0006893 | 1.21244232335e-10 | 0.583333333333 | EXOC2 EXOC5 EXOC6 EXOC6B EXOC8 EXOC1 EXOC4 | Golgi to plasma membrane transport |
| GO:0044448 | 1.00047614581e-09 | 0.666666666667 | EXOC3 EXOC5 EXOC6 EXOC6B EXOC8 EXOC1 EXOC4 EXOC2 | cell cortex part |
| REAC:R-HSA-1852241 | 1.53761702181e-09 | 0.666666666667 | EXOC7 EXOC5 EXOC6 EXOC3 EXOC8 EXOC1 EXOC4 EXOC2 | Organelle biogenesis and maintenance |
| GO:0098876 | 2.39158477368e-09 | 0.583333333333 | EXOC2 EXOC5 EXOC6 EXOC6B EXOC8 EXOC1 EXOC4 | vesicle-mediated transport to the plasma membrane |
| GO:0006892 | 1.13545823885e-08 | 0.583333333333 | EXOC2 EXOC5 EXOC6 EXOC6B EXOC8 EXOC1 EXOC4 | post-Golgi vesicle-mediated transport |
| GO:0005938 | 2.00261487296e-08 | 0.666666666667 | EXOC3 EXOC5 EXOC6 EXOC6B EXOC8 EXOC1 EXOC4 EXOC2 | cell cortex |
| CORUM:6169 | 2.47891894852e-08 | 0.25 | EXOC5 EXOC7 EXOC6 | Exocyst EXOC5-EXOC6-EXOC7 subcomplex |
| REAC:R-HSA-199991 | 5.32445859995e-07 | 0.666666666667 | EXOC7 EXOC5 EXOC6 EXOC3 EXOC8 EXOC1 EXOC4 EXOC2 | Membrane Trafficking |
| GO:0099568 | 5.40181531883e-07 | 0.666666666667 | EXOC3 EXOC5 EXOC6 EXOC6B EXOC8 EXOC1 EXOC4 EXOC2 | cytoplasmic region |
| REAC:R-HSA-5653656 | 8.13235200545e-07 | 0.666666666667 | EXOC7 EXOC5 EXOC6 EXOC3 EXOC8 EXOC1 EXOC4 EXOC2 | Vesicle-mediated transport |
| GO:0017160 | 1.20360142292e-05 | 0.333333333333 | EXOC5 EXOC8 EXOC2 EXOC4 | Ral GTPase binding |
| CORUM:6168 | 3.69160609814e-05 | 0.166666666667 | EXOC5 EXOC6 | Exocyst EXOC5-EXOC6 subcomplex |
| GO:0048193 | 9.04812191156e-05 | 0.583333333333 | EXOC2 EXOC5 EXOC6 EXOC6B EXOC8 EXOC1 EXOC4 | Golgi vesicle transport |
| WP:WP2290 | 0.00263124287192 | 0.166666666667 | EXOC8 EXOC2 | RalA downstream regulated genes |
| REAC:R-HSA-392499 | 0.00354745382445 | 0.666666666667 | EXOC7 EXOC5 EXOC6 EXOC3 EXOC8 EXOC1 EXOC4 EXOC2 | Metabolism of proteins |
| GO:0006887 | 0.0166236540646 | 0.583333333333 | EXOC3 EXOC5 EXOC6 EXOC6B EXOC1 EXOC4 EXOC2 | exocytosis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EXOC7 | EXOC6 | 1.0 | 0.949 | bioplex (EXOC6) bioplex_WMM boldt (EXOC6,EXOC7) Malo fraction boldt_WMM |
| EXOC1 | EXOC2 | 1.0 | 0.949 | bioplex (EXOC1) bioplex_WMM boldt (EXOC1,EXOC2) Malo fraction boldt_WMM |
| EXOC8 | EXOC6 | 1.0 | 0.949 | bioplex (EXOC6,EXOC8) bioplex_WMM boldt (EXOC6,EXOC8) Malo fraction boldt_WMM |
| EXOC8 | EXOC7 | 1.0 | 0.949 | bioplex (EXOC8) bioplex_WMM boldt (EXOC8) Malo fraction boldt_WMM |
| EXOC4 | EXOC2 | 1.0 | 0.949 | bioplex_WMM boldt (EXOC2,EXOC4) youn_WMM Malo fraction boldt_WMM treiber_WMM |
| EXOC5 | EXOC6 | 1.0 | 0.949 | bioplex (EXOC6) bioplex_WMM boldt (EXOC5,EXOC6) Malo fraction boldt_WMM |
| EXOC1 | EXOC4 | 0.999 | 0.949 | bioplex (EXOC1) bioplex_WMM boldt (EXOC1,EXOC4) Malo fraction boldt_WMM |
| EXOC8 | EXOC6B | 0.998 | 0.944 | bioplex (EXOC8) bioplex_WMM boldt (EXOC6B,EXOC8) Malo fraction boldt_WMM |
| EXOC4 | EXOC3 | 0.998 | 0.943 | bioplex (EXOC3) bioplex_WMM boldt (EXOC3,EXOC4) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| EXOC7 | EXOC6B | 0.992 | 0.911 | bioplex_WMM boldt (EXOC6B,EXOC7) Malo fraction boldt_WMM |
| EXOC2 | EXOC3 | 0.99 | 0.909 | bioplex (EXOC3) bioplex_WMM boldt (EXOC2,EXOC3) Malo fraction boldt_WMM treiber_WMM |
| EXOC1 | EXOC3 | 0.988 | 0.902 | bioplex (EXOC1,EXOC3) bioplex_WMM boldt (EXOC1,EXOC3) Malo fraction boldt_WMM |
| EXOC5 | EXOC7 | 0.979 | 0.895 | bioplex_WMM boldt (EXOC5,EXOC7) Malo fraction boldt_WMM |
| EXOC4 | EXOC7 | 0.959 | 0.865 | bioplex_WMM boldt (EXOC4,EXOC7) fraction boldt_WMM |
| EXOC4 | EXOC6 | 0.939 | 0.851 | bioplex (EXOC6) bioplex_WMM boldt (EXOC4,EXOC6) youn_WMM fraction boldt_WMM |
| EXOC7 | EXOC3 | 0.763 | 0.749 | bioplex (EXOC3) bioplex_WMM boldt (EXOC3) fraction boldt_WMM |
| EXOC8 | EXOC5 | 0.708 | 0.729 | bioplex (EXOC8) bioplex_WMM boldt (EXOC5,EXOC8) Malo fraction boldt_WMM |
| EXOC2 | EXOC6B | 0.685 | 0.712 | bioplex_WMM boldt (EXOC6B) fraction boldt_WMM |
| EXOC5 | EXOC6B | 0.653 | 0.69 | bioplex_WMM boldt (EXOC5,EXOC6B) Malo fraction boldt_WMM |
| EXOC1 | NCKAP5L | 0.617 | 0.675 | bioplex (EXOC1) bioplex_WMM boldt (EXOC1) boldt_WMM |
| IL1R2 | EXOC6B | 0.603 | 0.671 | bioplex (IL1R2) bioplex_WMM |
| EXOC1 | EXOC7 | 0.466 | 0.604 | bioplex (EXOC1) bioplex_WMM boldt (EXOC1) fraction boldt_WMM |
| EXOC4 | EXOC5 | 0.385 | 0.551 | bioplex_WMM boldt (EXOC4,EXOC5) youn_WMM gupta_WMM fraction boldt_WMM |
| EXOC1 | EXOC6 | 0.305 | 0.501 | bioplex (EXOC1,EXOC6) bioplex_WMM boldt (EXOC1) fraction boldt_WMM |
| EXOC8 | EXOC4 | 0.256 | 0.479 | bioplex (EXOC8) bioplex_WMM boldt (EXOC4,EXOC8) fraction boldt_WMM |
| EXOC2 | EXOC7 | 0.232 | 0.47 | bioplex_WMM boldt fraction boldt_WMM |
| EXOC4 | EXOC6B | 0.166 | 0.422 | bioplex_WMM boldt (EXOC4,EXOC6B) fraction boldt_WMM |
| EXOC8 | EXOC3 | 0.15 | 0.41 | bioplex (EXOC3,EXOC8) bioplex_WMM boldt fraction boldt_WMM |
| EXOC2 | EXOC6 | 0.128 | 0.398 | bioplex (EXOC6) bioplex_WMM boldt (EXOC6) fraction boldt_WMM |
| EXOC1 | EXOC8 | 0.126 | 0.4 | bioplex (EXOC1,EXOC8) bioplex_WMM boldt (EXOC8) fraction boldt_WMM |
| IL1R2 | EXOC6 | 0.119 | 0.392 | bioplex (IL1R2) bioplex_WMM |
| EXOC3 | EXOC6 | 0.077 | 0.352 | bioplex (EXOC3,EXOC6) bioplex_WMM boldt fraction boldt_WMM |
| EXOC3 | EXOC6B | 0.056 | 0.312 | bioplex (EXOC3) bioplex_WMM boldt fraction boldt_WMM |
| EXOC7 | DIP2B | 0.05 | 0.296 | fraction |
| EXOC1 | EXOC5 | 0.047 | 0.29 | bioplex (EXOC1) bioplex_WMM boldt (EXOC1,EXOC5) fraction boldt_WMM |
| EXOC5 | IL1R2 | 0.036 | 0.266 | bioplex (IL1R2) bioplex_WMM |
| EXOC1 | EXOC6B | 0.029 | 0.231 | bioplex (EXOC1) bioplex_WMM boldt (EXOC6B) fraction boldt_WMM |
| IL1R2 | EXOC7 | 0.027 | 0.225 | bioplex (IL1R2) bioplex_WMM |
| EXOC8 | EXOC2 | 0.021 | 0.187 | bioplex (EXOC8) bioplex_WMM boldt fraction boldt_WMM |
| EXOC5 | EXOC3 | 0.02 | 0.186 | bioplex (EXOC3) bioplex_WMM boldt (EXOC5) fraction boldt_WMM |
| EXOC5 | EXOC2 | 0.018 | 0.178 | bioplex_WMM boldt (EXOC5) fraction boldt_WMM |
| EXOC6B | EXOC6 | 0.017 | 0.173 | bioplex_WMM boldt boldt_WMM |
| EXOC8 | IL1R2 | 0.012 | 0.147 | bioplex (IL1R2) bioplex_WMM |
| EXOC8 | DIP2B | 0.011 | 0.148 | fraction |
| EXOC2 | IL1R2 | 0.011 | 0.135 | bioplex (IL1R2) bioplex_WMM |
| EXOC1 | IL1R2 | 0.011 | 0.142 | bioplex (IL1R2) bioplex_WMM |
| IL1R2 | EXOC3 | 0.01 | 0.122 | bioplex (IL1R2) bioplex_WMM |
| EXOC6B | DIP2B | 0.01 | 0.105 | fraction |
| NCKAP5L | EXOC6B | 0.008 | 0.081 | bioplex_WMM WMM_only |
| NCKAP5L | EXOC4 | 0.008 | 0.068 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| NCKAP5L | EXOC2 | 0.008 | 0.044 | bioplex_WMM boldt boldt_WMM |
| NCKAP5L | EXOC3 | 0.008 | 0.046 | bioplex_WMM boldt boldt_WMM |
| NCKAP5L | EXOC6 | 0.008 | 0.042 | bioplex_WMM boldt youn_WMM boldt_WMM |
| NCKAP5L | EXOC5 | 0.008 | 0.04 | bioplex_WMM boldt youn_WMM boldt_WMM |
| NCKAP5L | EXOC7 | 0.008 | 0.028 | bioplex_WMM boldt boldt_WMM |
| NCKAP5L | EXOC8 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| EXOC4 | IL1R2 | 0.007 | 0.004 | bioplex (IL1R2) bioplex_WMM |
| EXOC4 | DIP2B | 0.003 | 0.016 | youn_WMM fraction |
| EXOC6 | DIP2B | 0.003 | 0.02 | fraction |
| EXOC2 | DIP2B | 0.0 | 0.01 | fraction |
| EXOC1 | DIP2B | 0.0 | 0.01 | fraction |
| EXOC3 | DIP2B | 0.0 | 0.0 | fraction |
Images
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Complex HuMAP2_03022 has an average edge precision of 0.429 which is ranked 3030 out of all 6965 complexes.
Related Complexes