hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03038
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)] | UniProt NCBI |
| TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5531 | 1.00555407742e-05 | 1.0 | TNFRSF1A TRADD | Tumor necrosis factor receptor 1 signaling complex |
| CORUM:6347 | 1.67592346237e-05 | 1.0 | TNFRSF1A TRADD | TNF-R1 signaling complex |
| WP:WP2513 | 2.45903678934e-05 | 1.0 | TNFRSF1A TRADD | Nanoparticle triggered regulated necrosis |
| REAC:R-HSA-5357786 | 0.000110610948517 | 1.0 | TNFRSF1A TRADD | TNFR1-induced proapoptotic signaling |
| CORUM:6344 | 0.000175971963549 | 1.0 | TNFRSF1A TRADD | TNF-R1-associated signaling complex |
| KEGG:04920 | 0.000294129448977 | 1.0 | TNFRSF1A TRADD | Adipocytokine signaling pathway |
| KEGG:04064 | 0.000449510333482 | 1.0 | TNFRSF1A TRADD | NF-kappa B signaling pathway |
| KEGG:04668 | 0.000624149693812 | 1.0 | TNFRSF1A TRADD | TNF signaling pathway |
| REAC:R-HSA-5357956 | 0.000680424925724 | 1.0 | TNFRSF1A TRADD | TNFR1-induced NFkappaB signaling pathway |
| REAC:R-HSA-5357905 | 0.000729026706133 | 1.0 | TNFRSF1A TRADD | Regulation of TNFR1 signaling |
| KEGG:04071 | 0.000858752944782 | 1.0 | TNFRSF1A TRADD | Sphingolipid signaling pathway |
| WP:WP254 | 0.000979143739755 | 1.0 | TNFRSF1A TRADD | Apoptosis |
| KEGG:04210 | 0.00113070596705 | 1.0 | TNFRSF1A TRADD | Apoptosis |
| WP:WP1772 | 0.00120716351477 | 1.0 | TNFRSF1A TRADD | Apoptosis Modulation and Signaling |
| REAC:R-HSA-75893 | 0.00130722030065 | 1.0 | TNFRSF1A TRADD | TNF signaling |
| KEGG:05160 | 0.00133933945516 | 1.0 | TNFRSF1A TRADD | Hepatitis C |
| WP:WP231 | 0.00142624133782 | 1.0 | TNFRSF1A TRADD | TNF alpha Signaling Pathway |
| KEGG:05164 | 0.00158707348511 | 1.0 | TNFRSF1A TRADD | Influenza A |
| KEGG:05152 | 0.00163040505571 | 1.0 | TNFRSF1A TRADD | Tuberculosis |
| KEGG:04217 | 0.0016743202165 | 1.0 | TNFRSF1A TRADD | Necroptosis |
| KEGG:05167 | 0.00197399377215 | 1.0 | TNFRSF1A TRADD | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:05130 | 0.00227250014745 | 1.0 | TNFRSF1A TRADD | Pathogenic Escherichia coli infection |
| KEGG:05170 | 0.00287432751701 | 1.0 | TNFRSF1A TRADD | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.0029618660435 | 1.0 | TNFRSF1A TRADD | Human cytomegalovirus infection |
| KEGG:04010 | 0.00476209584058 | 1.0 | TNFRSF1A TRADD | MAPK signaling pathway |
| KEGG:05165 | 0.00707836525128 | 1.0 | TNFRSF1A TRADD | Human papillomavirus infection |
| KEGG:05168 | 0.010450786984 | 1.0 | TNFRSF1A TRADD | Herpes simplex virus 1 infection |
| GO:0071550 | 0.0126230555186 | 1.0 | TNFRSF1A TRADD | death-inducing signaling complex assembly |
| REAC:R-HSA-73887 | 0.0131978972662 | 1.0 | TNFRSF1A TRADD | Death Receptor Signalling |
| HP:0012280 | 0.0497341708567 | 0.5 | TNFRSF1A | Hepatic amyloidosis |
| HP:0100536 | 0.0497341708567 | 0.5 | TNFRSF1A | Abnormality of the fascia |
| HP:0100537 | 0.0497341708567 | 0.5 | TNFRSF1A | Fasciitis |
| CORUM:5540 | 0.0499173803268 | 0.5 | TRADD | TRAF2-TRADD complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TNFRSF1A | TRADD | 0.702 | 0.723 | bioplex (TNFRSF1A) bioplex_WMM |
Images
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Complex HuMAP2_03038 has an average edge precision of 0.723 which is ranked 1301 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TNFRSF1A | HuMAP2_03038 HuMAP2_03973 |
| TRADD | HuMAP2_03038 HuMAP2_03973 |