hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03046
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| JUP | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | UniProt NCBI |
| DSP | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0004791 | 2.00365960613e-05 | 1.0 | DSP JUP | Esophageal ulceration |
| HP:0100792 | 7.01280862145e-05 | 1.0 | DSP JUP | Acantholysis |
| HP:0011663 | 0.000120219576368 | 1.0 | DSP JUP | Right ventricular cardiomyopathy |
| HP:0006682 | 0.00015027447046 | 1.0 | DSP JUP | Ventricular extrasystoles |
| HP:0200097 | 0.000220402556674 | 1.0 | DSP JUP | Oral mucosal blisters |
| KEGG:05412 | 0.00037291412281 | 1.0 | DSP JUP | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| HP:0200041 | 0.000400731921226 | 1.0 | DSP JUP | Skin erosion |
| HP:0002224 | 0.000571042987746 | 1.0 | DSP JUP | Woolly hair |
| HP:0000695 | 0.000701280862145 | 1.0 | DSP JUP | Natal tooth |
| HP:0001030 | 0.000771408948359 | 1.0 | DSP JUP | Fragile skin |
| WP:WP2118 | 0.00087407580421 | 1.0 | DSP JUP | Arrhythmogenic Right Ventricular Cardiomyopathy |
| HP:0006288 | 0.00135580966681 | 1.0 | DSP JUP | Advanced eruption of teeth |
| HP:0025092 | 0.00210384258643 | 1.0 | DSP JUP | Epidermal acanthosis |
| HP:0004756 | 0.00273833479504 | 1.0 | DSP JUP | Ventricular tachycardia |
| WP:WP4239 | 0.00336999814539 | 1.0 | DSP JUP | Epithelial to mesenchymal transition in colorectal cancer |
| HP:0001279 | 0.00442808772954 | 1.0 | DSP JUP | Syncope |
| GO:0086083 | 0.00450823411379 | 1.0 | DSP JUP | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication |
| HP:0001798 | 0.00460173822874 | 1.0 | DSP JUP | Anonychia |
| HP:0011124 | 0.0053297345523 | 1.0 | DSP JUP | Abnormality of epidermal morphology |
| HP:0000535 | 0.00571376931014 | 1.0 | DSP JUP | Sparse and thin eyebrow |
| GO:0086073 | 0.00676235117068 | 1.0 | DSP JUP | bundle of His cell-Purkinje myocyte adhesion involved in cell communication |
| GO:0002934 | 0.00676235117068 | 1.0 | DSP JUP | desmosome organization |
| HP:0045074 | 0.00716308309191 | 1.0 | DSP JUP | Thin eyebrow |
| REAC:R-HSA-6809371 | 0.00796566421667 | 1.0 | DSP JUP | Formation of the cornified envelope |
| HP:0001640 | 0.00806472991466 | 1.0 | DSP JUP | Cardiomegaly |
| HP:0008066 | 0.00829849020205 | 1.0 | DSP JUP | Abnormal blistering of the skin |
| HP:0001649 | 0.00877602907484 | 1.0 | DSP JUP | Tachycardia |
| GO:0086042 | 0.00946729163895 | 1.0 | DSP JUP | cardiac muscle cell-cardiac muscle cell adhesion |
| HP:0001645 | 0.0102887920775 | 1.0 | DSP JUP | Sudden cardiac death |
| HP:0004308 | 0.0110902559199 | 1.0 | DSP JUP | Ventricular arrhythmia |
| HP:0045075 | 0.0119217746565 | 1.0 | DSP JUP | Sparse eyebrow |
| REAC:R-HSA-6805567 | 0.0136219059022 | 1.0 | DSP JUP | Keratinization |
| HP:0008404 | 0.0152278130066 | 1.0 | DSP JUP | Nail dystrophy |
| HP:0001695 | 0.0155483985436 | 1.0 | DSP JUP | Cardiac arrest |
| GO:0086080 | 0.020287053512 | 1.0 | DSP JUP | protein binding involved in heterotypic cell-cell adhesion |
| HP:0001644 | 0.0254665135939 | 1.0 | DSP JUP | Dilated cardiomyopathy |
| HP:0100840 | 0.0275703561803 | 1.0 | DSP JUP | Aplasia/Hypoplasia of the eyebrow |
| HP:0000982 | 0.0288727349243 | 1.0 | DSP JUP | Palmoplantar keratoderma |
| GO:0086069 | 0.029754345151 | 1.0 | DSP JUP | bundle of His cell to Purkinje myocyte communication |
| HP:0010719 | 0.032028498804 | 1.0 | DSP JUP | Abnormality of hair texture |
| HP:0002031 | 0.0334310605282 | 1.0 | DSP JUP | Abnormal esophagus morphology |
| HP:0001596 | 0.0388309231668 | 1.0 | DSP JUP | Alopecia |
| HP:0008386 | 0.0398561289986 | 1.0 | DSP JUP | Aplasia/Hypoplasia of the nails |
| GO:0098911 | 0.0410249304355 | 1.0 | DSP JUP | regulation of ventricular cardiac muscle cell action potential |
| HP:0001635 | 0.0457335305099 | 1.0 | DSP JUP | Congestive heart failure |
| HP:0007548 | 0.0497341708567 | 0.5 | DSP | Palmoplantar keratosis with erythema and scale |
| HP:0031193 | 0.0497341708567 | 0.5 | JUP | Abnormal morphology of right ventricular trabeculae |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DSP | JUP | 0.858 | 0.796 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_03046 has an average edge precision of 0.796 which is ranked 933 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| JUP | HuMAP2_00172 HuMAP2_01725 HuMAP2_03046 HuMAP2_05547 |
| DSP | HuMAP2_00172 HuMAP2_00512 HuMAP2_01725 HuMAP2_01970 HuMAP2_03046 HuMAP2_04038 |