hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03050
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SUCLG2 | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG) | UniProt NCBI |
| SUCLG1 | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) | UniProt NCBI |
| SUCLA2 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4236 | 2.25436181618e-09 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | Disorders of the Krebs cycle |
| WP:WP78 | 4.37990295714e-08 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | TCA Cycle (aka Krebs or citric acid cycle) |
| GO:0004774 | 9.08185760231e-08 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | succinate-CoA ligase activity |
| KEGG:00020 | 1.09884462513e-07 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | Citrate cycle (TCA cycle) |
| KEGG:00640 | 1.79953098981e-07 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | Propanoate metabolism |
| REAC:R-HSA-71403 | 5.97963891637e-07 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | Citric acid cycle (TCA cycle) |
| GO:0006104 | 1.81637152046e-06 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | succinyl-CoA metabolic process |
| CORUM:394 | 3.35600554376e-06 | 0.666666666667 | SUCLG1 SUCLA2 | Succinyl-CoA synthetase, ADP-forming |
| CORUM:393 | 3.35600554376e-06 | 0.666666666667 | SUCLG2 SUCLG1 | Succinyl-CoA synthetase, GDP-forming |
| KEGG:01200 | 7.23132386252e-06 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | Carbon metabolism |
| REAC:R-HSA-71406 | 9.93609173322e-06 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0016878 | 0.000208882724853 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | acid-thiol ligase activity |
| REAC:R-HSA-1428517 | 0.000330512177188 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0006099 | 0.000368723418654 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | tricarboxylic acid cycle |
| GO:0016877 | 0.000543458358922 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | ligase activity, forming carbon-sulfur bonds |
| HP:0012120 | 0.000927625684184 | 0.666666666667 | SUCLG1 SUCLA2 | Methylmalonic aciduria |
| GO:0042709 | 0.00135247023414 | 0.666666666667 | SUCLG2 SUCLA2 | succinate-CoA ligase complex |
| GO:0004775 | 0.00135247023414 | 0.666666666667 | SUCLG1 SUCLA2 | succinate-CoA ligase (ADP-forming) activity |
| GO:0009060 | 0.00541641987402 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | aerobic respiration |
| HP:0003215 | 0.00587799905401 | 0.666666666667 | SUCLG1 SUCLA2 | Dicarboxylic aciduria |
| GO:0035383 | 0.00746165420606 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | thioester metabolic process |
| GO:0006637 | 0.00746165420606 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | acyl-CoA metabolic process |
| KEGG:01100 | 0.0105851300972 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | Metabolic pathways |
| HP:0001992 | 0.0172167410086 | 0.666666666667 | SUCLG1 SUCLA2 | Organic aciduria |
| GO:0034032 | 0.0196004650773 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | purine nucleoside bisphosphate metabolic process |
| GO:0033875 | 0.0196004650773 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | ribonucleoside bisphosphate metabolic process |
| GO:0033865 | 0.0196004650773 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | nucleoside bisphosphate metabolic process |
| GO:0016874 | 0.0288576025313 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | ligase activity |
| GO:0045333 | 0.0442598881134 | 1.0 | SUCLG2 SUCLG1 SUCLA2 | cellular respiration |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SUCLA2 | SUCLG1 | 0.988 | 0.901 | bioplex (SUCLA2,SUCLG1) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| SUCLG2 | SUCLG1 | 0.924 | 0.843 | bioplex (SUCLG1,SUCLG2) bioplex_WMM Guru fraction |
| SUCLA2 | SUCLG2 | 0.004 | 0.012 | bioplex (SUCLA2,SUCLG2) bioplex_WMM Guru fraction |
Images
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Complex HuMAP2_03050 has an average edge precision of 0.585 which is ranked 2009 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SUCLG2 | HuMAP2_02509 HuMAP2_03050 HuMAP2_03427 HuMAP2_03979 |
| SUCLG1 | HuMAP2_02703 HuMAP2_03050 HuMAP2_03427 |
| SUCLA2 | HuMAP2_00179 HuMAP2_03050 HuMAP2_03427 HuMAP2_04460 HuMAP2_05892 |